Study Finds Combination Therapy May Help Those With a History of Recurrent Depression to Quit Smoking

2001 ◽  
Author(s):  
Keyword(s):  
Combination Therapy ◽  
Recurrent Depression ◽  
Quit Smoking ◽  
History Of

scholarly journals Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection

2020 ◽  
Author(s):  
Etienne Meriglier ◽  
Claire Rivoisy ◽  
Mojgan Hessamfar ◽  
Noelle Bernard ◽  
Ines Aureau ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Cohort Study ◽  
Clinical Practice ◽  
Combination Therapy ◽  
Observational Cohort Study ◽  
Potential Drug ◽  
Clinical Evaluations ◽  
History Of ◽  
Observational Cohort ◽  
Ecg Abnormalities

Abstract Background Combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir has been suggested as an approach to improve the outcome of patients with moderate/severe COVID-19 infection. Objectives To examine the safety of combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir. Methods This was an observational cohort study of patients hospitalized for COVID-19 pneumonia treated with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir. Clinical evaluations, electrocardiograms and the pharmacokinetics of hydroxychloroquine, darunavir and lopinavir were examined according to clinical practice and guidelines. Results Twenty-one patients received hydroxychloroquine with lopinavir/ritonavir (median age 68 years; 10 males) and 25 received hydroxychloroquine with darunavir/ritonavir (median age 71 years; 15 males). During treatment, eight patients (17.4%) developed ECG abnormalities. Ten patients discontinued treatment, including seven for ECG abnormalities a median of 5 (range 2–6) days after starting treatment. All ECG abnormalities reversed 1–2 days after interrupting treatment. Four patients died within 14 days. ECG abnormalities were significantly associated with age over 70 years, coexisting conditions (such as hypertension, chronic cardiovascular disease and kidney failure) and initial potential drug interactions, but not with the hydroxychloroquine concentration. Conclusions Of the patients with COVID-19 who received hydroxychloroquine with lopinavir or darunavir, 17% had ECG abnormalities, mainly related to age or in those with a history of cardiovascular disease.

scholarly journals Triple versus LAMA/LABA combination therapy for patients with COPD: a systematic review and meta-analysis

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Akira Koarai ◽  
Mitsuhiro Yamada ◽  
Tomohiro Ichikawa ◽  
Naoya Fujino ◽  
Tomotaka Kawayama ◽  
...  
Keyword(s):  
Systematic Review ◽  
Combination Therapy ◽  
Triple Therapy ◽  
Odds Ratio ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Beta Agonist ◽  
History Of ◽  
Dyspnea Score ◽  
Long Acting

Abstract Background Recently, the addition of inhaled corticosteroid (ICS) to long-acting muscarinic antagonist (LAMA) and long-acting beta-agonist (LABA) combination therapy has been recommended for patients with COPD who have severe symptoms and a history of exacerbations because it reduces the exacerbations. In addition, a reducing effect on mortality has been shown by this treatment. However, the evidence is mainly based on one large randomized controlled trial IMPACT study, and it remains unclear whether the ICS add-on treatment is beneficial or not. Recently, a large new ETHOS trial has been performed to clarify the ICS add-on effects. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy and safety including ETHOS trial. Methods We searched relevant randomized control trials (RCTs) and analyzed the exacerbations, quality of life (QOL), dyspnea symptom, lung function and adverse events including pneumonia and mortality, as the outcomes of interest. Results We identified a total of 6 RCTs in ICS add-on protocol (N = 13,579). ICS/LAMA/LABA treatment (triple therapy) significantly decreased the incidence of exacerbations (rate ratio 0.73, 95% CI 0.64–0.83) and improved the QOL score and trough FEV1 compared to LAMA/LABA. In addition, triple therapy significantly improved the dyspnea score (mean difference 0.33, 95% CI 0.18–0.48) and mortality (odds ratio 0.66, 95% CI 0.50–0.87). However, triple therapy showed a significantly higher incidence of pneumonia (odds ratio 1.52, 95% CI 1.16–2.00). In the ICS-withdrawal protocol including 2 RCTs, triple therapy also showed a significantly better QOL score and higher trough FEV1 than LAMA/LABA. Concerning the trough FEV1, QOL score and dyspnea score in both protocols, the differences were less than the minimal clinically important difference. Conclusion Triple therapy causes a higher incidence of pneumonia but is a more preferable treatment than LAMA/LABA due to the lower incidence of exacerbations, higher trough FEV1 and better QOL score. In addition, triple therapy is also superior to LABA/LAMA due to the lower mortality and better dyspnea score. However, these results should be only applied to patients with symptomatic moderate to severe COPD and a history of exacerbations. Clinical Trial Registration: PROSPERO; CRD42020191978.

scholarly journals Type 2 Diabetes Mellitus. From the start – combination therapy

2018 ◽  
Vol 21 (5) ◽  
pp. 386-394 ◽  
Author(s):  
Francesco Indovina ◽  
Pierpaolo Falcetta ◽  
Stefano Del Prato
Keyword(s):  
Type 2 Diabetes ◽  
Combination Therapy ◽  
Diabetes Diagnosis ◽  
Good Glycemic Control ◽  
Chronic Hyperglycemia ◽  
Increased Risk ◽  
History Of ◽  
First Time ◽  
Early Combination Therapy

Modern treatment of T2DM requires a shift in paradigm with appropriate intensification of therapy from the very first time of diabetes diagnosis. This is supported by data showing how even a moderate delay in achieving good glycemic control can translate into a later increased risk of developing diabetic complications. The recognition of the complexity of the pathogenesis of T2DM leads to the appreciation of the importance of attacking the disease from different angles, i.e. simultaneous tackling of multiple mechanisms contributing to hyperglycemia. From the turn of century a growing number of new anti-hyperglycemic agents have been made available. As compared to the older ones, these new medicines have a more targeted mechanism of action as they act at the level of the specific pathophysiologic disturbances accounting the development and progression of hyperglycemia. Because of that drugs can be use in combination taking advantage of their complementary mechanisms of action and synergistic. If introduced earlier in the natural history of the disease combination therapy may contribute avoiding undesirable exposure to even mild chronic hyperglycemia and provide early benefits. With respect to that in this review we will discuss advantages, disadvantages and still unanswered questions related to the use of early combination therapy in type 2 diabetes.

scholarly journals Trait Mindfulness May Buffer Against the Deleterious Effects of Childhood Abuse in Recurrent Depression: A Retrospective Exploratory Study

2018 ◽  
Author(s):  
Shadi Beshai
Keyword(s):  
Early Childhood ◽  
Childhood Abuse ◽  
Childhood Maltreatment ◽  
Prospective Trial ◽  
Structured Interview ◽  
Trait Mindfulness ◽  
Recurrent Depression ◽  
Related Factors ◽  
History Of Childhood ◽  
History Of

Objective: Individuals with a history of childhood maltreatment are particularly vulnerable to a longer course of depression. Immunization theories of resilience suggest that resilience and related factors may buffer against the deleterious effects of early childhood adversity. Trait mindfulness is linked to resilience and may be a pathway to cultivating this dynamic process. In this study, we investigated whether trait mindfulness can buffer against the effects of early childhood maltreatment in predicting lifetime number of months depressed. Method: We recruited 43 previously depressed, currently remitted patients, and retrospectively examined their depression history (using a structured interview, LIFE-SCID), their self-reported experience of maltreatment in the first 16 years of life (MOPS), and their levels of trait mindfulness (MAAS). Results: We found that number of months depressed in a lifetime was positively associated with reported childhood maltreatment, and negatively associated with trait mindfulness. Secondly, we found evidence that trait mindfulness significantly moderated the relationship of early childhood maltreatment and number of months depressed. Specifically, it appears that individuals who report severe histories of maltreatment are especially vulnerable to recurrent depression if they are also reporting low levels of trait mindfulness. Conclusions: Increasing mindfulness may be warranted among individuals reporting a history of childhood abuse with lower baselines of trait mindfulness; however, results of this retrospective study require replication in a larger, prospective trial.

The Association Between Smoking Cessation Period and Metabolic Syndrome in Korean Men

2018 ◽  
Vol 30 (5) ◽  
pp. 415-424 ◽  
Author(s):  
Hwang Sik Shin ◽  
Jung Eun Oh ◽  
Yong Jin Cho
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Smoking Cessation ◽  
Odds Ratio ◽  
Health And Nutrition ◽  
Quit Smoking ◽  
Education Levels ◽  
History Of ◽  
Former Smokers ◽  
Never Smokers

The association between smoking cessation period and metabolic syndrome (MS) is currently unknown. We studied 6032 men aged >19 years who participated in the Korean National Health and Nutrition Examination Surveys between 2010 and 2012. The risk of MS according to the amount of smoking and duration of smoking cessation was examined, and adjusted for age, amount of alcohol consumed, physical activity, body mass index, income, and education levels. Compared with never-smokers, there was a significant increase in the risk of MS among current smokers >10 pack-years and former smokers with a history of pack-years >30. The odds ratio for MS increased with smoking amount in both current and former smokers. But the risk of MS in former smokers was no longer significant after 20 years of smoking cessation adjusted for past smoking amount. Thus, to prevent MS, current smokers should quit smoking early and former smokers should continue quitting.

scholarly journals Latent Profile Analysis of the Five Facet Mindfulness Questionnaire in a Sample With a History of Recurrent Depression

Assessment ◽  
2017 ◽  
Vol 27 (1) ◽  
pp. 149-163 ◽  
Author(s):  
Jenny Gu ◽  
Anke Karl ◽  
Ruth Baer ◽  
Clara Strauss ◽  
Thorsten Barnhofer ◽  
...  
Keyword(s):  
Psychological Functioning ◽  
Latent Profile Analysis ◽  
Profile Analysis ◽  
Optimal Number ◽  
Future Research ◽  
Five Facet Mindfulness Questionnaire ◽  
Recurrent Depression ◽  
Mindfulness Skills ◽  
History Of ◽  
Latent Profile

Extending previous research, we applied latent profile analysis in a sample of adults with a history of recurrent depression to identify subgroups with distinct response profiles on the Five Facet Mindfulness Questionnaire and understand how these relate to psychological functioning. The sample was randomly divided into two subsamples to first examine the optimal number of latent profiles (test sample; n = 343) and then validate the identified solution (validation sample; n = 340). In both test and validation samples, a four-profile solution was revealed where two profiles mapped broadly onto those previously identified in nonclinical samples: “high mindfulness” and “nonjudgmentally aware.” Two additional subgroups, “moderate mindfulness” and “very low mindfulness,” were observed. “High mindfulness” was associated with the most adaptive psychological functioning and “very low mindfulness” with the least adaptive. In most people with recurrent depression, mindfulness skills are expressed evenly across different domains. However, in a small minority a meaningful and replicable uneven profile indicating nonjudgmental awareness is observable. Current findings require replication and future research should examine the extent to which profiles change from periods of wellness to illness in people with recurrent depression and how profiles are influenced by exposure to mindfulness-based intervention.

scholarly journals Memory specificity and mindfulness jointly moderate the effect of reflective pondering on depressive symptoms in individuals with a history of recurrent depression.

2015 ◽  
Vol 124 (2) ◽  
pp. 246-255 ◽  
Author(s):  
Kate Brennan ◽  
Thorsten Barnhofer ◽  
Catherine Crane ◽  
Danielle Duggan ◽  
J. Mark G. Williams
Keyword(s):  
Depressive Symptoms ◽  
Recurrent Depression ◽  
Memory Specificity ◽  
History Of

The Method of Loci Improves Longer-Term Retention of Self-Affirming Memories and Facilitates Access to Mood-Repairing Memories in Recurrent Depression

2016 ◽  
Vol 4 (6) ◽  
pp. 1065-1072 ◽  
Author(s):  
Aliza Werner-Seidler ◽  
Tim Dalgleish
Keyword(s):  
Mood Induction ◽  
Memory Recall ◽  
Recurrent Depression ◽  
Induction Procedure ◽  
Mnemonic Strategy ◽  
Term Retention ◽  
Method Of Loci ◽  
History Of ◽  
History Of Depression

The Method-of-Loci (MoL) is a mnemonic strategy that individuals with a history of depression can use to facilitate access to self-affirming memories. In the current study, we investigated (a) the utility of the MoL to enhance access to a preidentified set of personal memories and (b) the ability of the MoL to facilitate the recollection of memories to regulate emotion. Participants in remission from chronic depression used a MoL or rehearsal procedure to facilitate memory recall. Participants using the MoL showed superior retention of this material at both a 1-week and 3-month follow-up memory test, relative to the rehearsal group. For both groups, memory recall effectively repaired mood after a mood induction procedure. Using a diary measure, participants trained to use the MoL reported greater use of the memory repository to offset downturns in mood in day-to-day life, indicating that this could be a useful strategy for mood regulation.

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