Dreams, Daydreams, and the Stream of Thought: Their Adaptive Role in Cognition And Personality

1969 ◽  
Author(s):  
Jerome L. Singer
Keyword(s):  
2018 ◽  
Vol 54 (6) ◽  
pp. 78-93
Author(s):  
V. V. Grubinko ◽  
O. I. Bodnar ◽  
A. I. Lutsiv ◽  
G. B. Viniarska
Keyword(s):  

2014 ◽  
Vol 6 (11) ◽  
pp. 3025-3038 ◽  
Author(s):  
Barbara Ottolini ◽  
Michael J. Hornsby ◽  
Razan Abujaber ◽  
Jacqueline A.L. MacArthur ◽  
Richard M. Badge ◽  
...  

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Borja Figueirido ◽  
Alberto Martín-Serra ◽  
Alejandro Pérez-Ramos ◽  
David Velasco ◽  
Francisco J. Pastor ◽  
...  

AbstractOrganisms comprise multiple interacting parts, but few quantitative studies have analysed multi-element systems, limiting understanding of phenotypic evolution. We investigate how disparity of vertebral morphology varies along the axial column of mammalian carnivores — a chain of 27 subunits — and the extent to which morphological variation have been structured by evolutionary constraints and locomotory adaptation. We find that lumbars and posterior thoracics exhibit high individual disparity but low serial differentiation. They are pervasively recruited into locomotory functions and exhibit relaxed evolutionary constraint. More anterior vertebrae also show signals of locomotory adaptation, but nevertheless have low individual disparity and constrained patterns of evolution, characterised by low-dimensional shape changes. Our findings demonstrate the importance of the thoracolumbar region as an innovation enabling evolutionary versatility of mammalian locomotion. Moreover, they underscore the complexity of phenotypic macroevolution of multi-element systems and that the strength of ecomorphological signal does not have a predictable influence on macroevolutionary outcomes.


2019 ◽  
Author(s):  
Benjamin Oosterhoff

This study examined associations among adolescent risk preference and political engagement using nationally representative Monitoring the Future data from high school seniors (N=109,574; modal age=18 years) spanning 1976-2014. Greater risk preference was associated with greater past voting, donating to a campaign, writing government officials, boycotting, and protesting. Greater risk preference was associated with higher future intentions to boycott and protest, but lower intentions to donate to or volunteer for a campaign. In general, associations between risk preference and political engagement became stronger with higher levels of political interest. Results highlight the importance of considering the adaptive role of adolescent risk preference and suggest that political engagement may be a constructive outlet for youth who pursue or are comfortable taking risks.


2013 ◽  
Vol 41 (1) ◽  
pp. 432-435 ◽  
Author(s):  
Lina Kaminski ◽  
Shai Naparstek ◽  
Lina Kandiba ◽  
Chen Cohen-Rosenzweig ◽  
Adi Arbiv ◽  
...  

Although performed by members of all three domains of life, the archaeal version of N-glycosylation remains the least understood. Studies on Haloferax volcanii have, however, begun to correct this situation. A combination of bioinformatics, molecular biology, biochemical and mass spectrometry approaches have served to delineate the Agl pathway responsible for N-glycosylation of the S-layer glycoprotein, a reporter of this post-translational modification in Hfx. volcanii. More recently, differential N-glycosylation of the S-layer glycoprotein as a function of environmental salinity was demonstrated, showing that this post-translational modification serves an adaptive role in Hfx. volcanii. Furthermore, manipulation of the Agl pathway, together with the capability of Hfx. volcanii to N-glycosylate non-native proteins, forms the basis for establishing this species as a glyco-engineering platform. In the present review, these and other recent findings are addressed.


2015 ◽  
Vol 31 (5) ◽  
pp. 438-443 ◽  
Author(s):  
Geoff P. Bostick ◽  
Cory Toth ◽  
Bruce D. Dick ◽  
Eloise C.J. Carr ◽  
Larry W. Stitt ◽  
...  

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Akihiro Shirakabe ◽  
Yoshiyuki Ikeda ◽  
Peiyong Zai ◽  
Junichi Sadoshima

Dynamin-related protein 1 (Drp1) plays an essential role in maintaining the quality control of mitochondria through mitochondrial (Mt) fission and mitophagy. We investigated how Mt function, autophagy and Drp1 are regulated in the heart during pressure overload (PO) and whether endogenous Drp1 plays an important role in regulating cardiac function. Mice were subjected to transverse aortic constriction (TAC) at multiple time points between 6 hours and 30 days. Left ventricular (LV) weight/tibial length (LVW/TL) was significantly elevated at Day 7 (TAC vs sham; 5.92 ± 0.27 vs 4.22 ± 0.12, p<0.05). Ejection fraction (EF) was maintained at Day 7, but gradually decreased thereafter (at 30 days; 65±9 vs 83±9 %, p<0.05). LC3-II was decreased (-45.7%, p<0.05) while p62 accumulated (1.17 fold, p<0.05) significantly at Day 7. Both Mt ATP content (-65.6%, p<0.05) and production (-90.3%, p<0.05) were reduced significantly at Days 7 and 14, respectively, and thereafter. Mt mass, evaluated by electron microscopy, was also reduced (-19.9%, p<0.05) at Day 7. Drp1 accumulated in mitochondria at Day 7, and S616 phosphorylation of Drp1, associated with increased activity, was increased at Day 7. Thus, PO suppresses autophagy and induces Mt dysfunction by Day 7, at which time Drp1 accumulates in mitochondria and Mt mass is decreased. To examine the functional significance of endogenous Drp1 during PO, cardiac-specific heterozygous Drp1 knock out (Drp-hetCKO) mice were subjected to TAC. At Day 7, decreases in EF (61± 2 vs 84 ± 7%, p<0.05) and increases in LVW/TL (7.22 ± 0.26 vs 5.86 ± 0.65, p<0.05) and lung weight/TL (12.01 ± 1.10 vs 6.31 ± 1.19, p<0.05) were exacerbated in Drp-hetCKO compared to in control mice. LV end diastolic pressure was significantly higher (22.0 ± 2.8 vs 5.7 ± 2.9 mmHg, p<0.05) and myocardial fibrosis (14.1 ± 2.5 vs 6.2 ± 4.3 %, p<0.05) was greater in Drp-hetCKO than in control mice. Mt mass was also significantly greater in Drp-hetCKO than in control mice (relative Mt mass, 1.21 ± 0.46 vs 1.00 ± 0.02, p<0.05). These results suggest that PO inhibits autophagy and induces mitochondrial dysfunction by Day7, which coincides with Mt accumulation of Drp1. Drp1 plays an adaptive role in this condition, mediating decreases in Mt mass and protecting the heart from dysfunction.


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