Heritability of personality: A meta-analysis of behavior genetic studies.

2015 ◽  
Vol 141 (4) ◽  
pp. 769-785 ◽  
Author(s):  
Tena Vukasović ◽  
Denis Bratko
Keyword(s):  
Meta Analysis ◽  
Behavior Genetic ◽  
Genetic Studies

Genetics of Depression

2013 ◽  
pp. 396-410
Author(s):  
Douglas F. Levinson
Keyword(s):  
Association Studies ◽  
Meta Analysis ◽  
Lifetime Risk ◽  
Depression And Anxiety ◽  
Genetic Studies ◽  
Candidate Gene Studies ◽  
Methodological Problems ◽  
Continuous Measures ◽  
Depressive Episodes ◽  
Significant Linkage

Categorical major depressive disorder has been the focus of most genetic studies, although some studies use continuous measures or consider both depression and anxiety. Lifetime risk of major depression is high (12-20%), heritability is below 40%, and the relative risk to first-degree relatives is approximately 3. These characteristics are challenging for current genetic methods. There have been several significant linkage findings which do not consistently replicate. Genomewide association studies have not produced significant findings, but analyses that cut across diagnostic boundaries seem promising. Candidate gene studies have been fraught with methodological problems, although the largest meta-analysis to date supported the hypothesis that 5-HTTLPR genotype and specific stressors interact to predict depressive episodes (but not lifetime risk of depression). Future steps include application of sequencing and stem cell technologies. Methods are need to build larger samples with more detailed clinical assessment. Outstanding genetic epidemiological issues should be addressed by new studies.

scholarly journals Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Shiwei Zhu ◽  
Ben Wang ◽  
Qiong Jia ◽  
Liping Duan
Keyword(s):  
Irritable Bowel Syndrome ◽  
Single Nucleotide Polymorphisms ◽  
Meta Analysis ◽  
Systemic Review ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Genetic Studies ◽  
Increased Risk ◽  
Rome Iii ◽  
Irritable Bowel

Abstract Background Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review was to synthesize all the published SNPs studies of IBS through meta-analysis to objectively evaluate the relevance of SNPs to IBS risks. Methods IBS - related polymorphisms studies from 2000 to 2018 were searched. Pooled odds ratios with a 95% confidence interval for each SNP were evaluated through five genetic models. Ethnicity, ROME criteria and IBS subtypes were defined for subgroup analyze. Results Ten relevant genes were evaluated. SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients. IL10 rs1800896 GG genotype associated with a decreased risk of IBS. No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study. Conclusions This meta-analysis presents an in-depth overview for IBS SNPs analysis. It was confirmed that polymorphisms of TNFSF15 associated with increased IBS risk, while IL10 rs1800896 associated with decreased IBS risk. It might offer some insights into polymorphisms of inflammation factors which might affect IBS susceptibility. Moreover, the analysis also emphasizes the importance of diagnostic criteria and phenotype homogeneity in IBS genetic studies.

scholarly journals Meta-analysis of Genetic Studies in Ischemic Stroke

2004 ◽  
Vol 61 (11) ◽  
pp. 1652 ◽  
Author(s):  
Juan P. Casas ◽  
Aroon D. Hingorani ◽  
Leonelo E. Bautista ◽  
Pankaj Sharma
Keyword(s):  
Ischemic Stroke ◽  
Meta Analysis ◽  
Genetic Studies

scholarly journals The nature of nurture: effects of parental genotypes

2017 ◽  
Author(s):  
Augustine Kong ◽  
Gudmar Thorleifsson ◽  
Michael L. Frigge ◽  
Bjarni J. Vilhjálmsson ◽  
Alexander I. Young ◽  
...  
Keyword(s):  
Educational Attainment ◽  
Meta Analysis ◽  
Genetic Component ◽  
Sequence Variants ◽  
Genetic Studies ◽  
Polygenic Score ◽  
Polygenic Scores

AbstractSequence variants in the parental genomes that are not transmitted to a child/proband are often ignored in genetic studies. Here we show that non-transmitted alleles can impact a child through their effects on the parents and other relatives, a phenomenon we call genetic nurture. Using results from a meta-analysis of educational attainment, the polygenic score computed for the non-transmitted alleles of 21,637 probands with at least one parent genotyped has an estimated effect on the educational attainment of the proband that is 29.9% (P = 1.6×10−14) of that of the transmitted polygenic score. Genetic nurturing effects of this polygenic score extend to other traits. Paternal and maternal polygenic scores have similar effects on educational attainment, but mothers contribute more than fathers to nutrition/heath related traits.One Sentence SummaryNurture has a genetic component, i.e. alleles in the parents affect the parents’ phenotypes and through that influence the outcomes of the child.

scholarly journals Heritability of Personality

2017 ◽  
Vol 26 (1) ◽  
pp. 1-24 ◽  
Author(s):  
Denis Bratko ◽  
Ana Butković ◽  
Tena Vukasović Hlupić
Keyword(s):  
Current Knowledge ◽  
Familial Aggregation ◽  
Meta Analysis ◽  
Molecular Genetic ◽  
Monozygotic Twins ◽  
Environment Interaction ◽  
Genetic Studies ◽  
Behavioral Genetic ◽  
Dizygotic Twins ◽  
Intraclass Correlations

The aim of this study is to simplify the issue of the concept of heritability, to give an introduction to the behavioral genetic theory and methods, as well as to give an overview of the current knowledge about heritability of personality and the quantitative and molecular genetic approach to estimate heritability. Following that, results on heritability of personality are summarized. In addition, we reanalyzed all available behavioral genetic studies published before 2010, which were included in Vukasović and Bratko (2015) meta-analysis, to estimate the correlations between different family members: 1) monozygotic twins reared together; 2) monozygotic twins reared apart; 3) dizygotic twins reared together; 4) dizygotic twins reared apart; 5) mother and offspring; 6) father and offspring. Estimates of the family resemblance for personality were .54 from intraclass correlations for twin pairs reared together, .45 for intraclass correlations for monozygotic twin pairs reared apart, and .26 and .28 for familial aggregation. This finding is in line with the conclusion of the previous meta-analysis, which showed that the study design is a significant moderator of personality heritability, with twin studies showing higher estimates compared to family and adoption studies. Following that, findings from molecular genetic studies on personality and from gene-environment interaction studies are summarized. Finally, recommendations for future studies are given.

Association of PPARG Gene Polymorphisms Pro12Ala with Type 2 Diabetes Mellitus: A Meta-analysis

2019 ◽  
Vol 15 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Junyan Li ◽  
Xiaohong Niu ◽  
JianBo Li ◽  
Qingzhong Wang
Keyword(s):  
Publication Bias ◽  
Chinese Population ◽  
Meta Analysis ◽  
Genetic Data ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Genetic Studies ◽  
Combined Analysis ◽  
Pparg Gene

Background:Previous studies suggested that the single nucleotide polymorphisms of Pro12Ala located within the PPARG gene were significantly associated with the T2DM. Recently, the genetic studies on Pro12Ala were conducted in the different ethnic groups and the results of each study were shown to be inconsistent. Moreover, the systematic review has not been updated since 2000.Objective:To further validate the risk of Pro12Ala for T2DM disease based on the genetic data.Methods:The genetic studies on the Pro12Ala in the T2DM were searched in the PubMed and PMC database from January 2000 to October 2017. The meta-analysis was conducted with the CMA software.Results:The meta-analysis collected 14 studies including 20702 cases and 36227 controls. The combined analysis of all studies found that Pro12Ala was shown to be significantly associated with T2DM and the Ala allele played the increasing risks for the disease. Nevertheless, publication bias was detected in the combined analysis. The subgroup analysis indicated that Pro12Ala was found to be significant in the Caucasian and Chinese population. There was no heterogeneity and publication bias in these two groups.Conclusion:The meta-analysis confirmed the evidence that the Pro12Ala was the susceptible variant for the decreasing risks for the T2DM

Sign in / Sign up

Export Citation Format

Share Document