scholarly journals Analysis of learning deficits in aged rats on the W-track continuous spatial alternation task.

2018 ◽  
Vol 132 (6) ◽  
pp. 512-519 ◽  
Author(s):  
Adele J. Kapellusch ◽  
Adam W. Lester ◽  
Benjamin A. Schwartz ◽  
Anne C. Smith ◽  
Carol A. Barnes
Keyword(s):  
Aged Rats ◽  
Learning Deficits ◽  
Spatial Alternation ◽  
Alternation Task

A Code for Spatial Alternation During Fixation in Rat Hippocampal CA1 Neurons

2009 ◽  
Vol 102 (1) ◽  
pp. 556-567 ◽  
Author(s):  
Muneyoshi Takahashi ◽  
Johan Lauwereyns ◽  
Yoshio Sakurai ◽  
Minoru Tsukada
Keyword(s):  
Internal Representation ◽  
Spatial Choice ◽  
Unit Recording ◽  
Ca1 Neurons ◽  
Spatial Alternation ◽  
Baseline Activity ◽  
Hippocampal Ca1 ◽  
Male Wistar Rats ◽  
The Right ◽  
Alternation Task

The classical notion of hippocampal CA1 “place cells,” whose activity tracks physical locations, has undergone substantial revision in recent years. Here, we provide further evidence of an abstract spatial code in hippocampal CA1, which relies on memory and adds complexity to the basic “place cell.” Using a nose-poking paradigm with four male Wistar rats, we specifically concentrated on activity during fixation, when the rat was immobile and waiting for the next task event in a memory-guided spatial alternation task. The rat had to alternate between choosing the right and left holes on a trial-by-trial basis, without any sensory cue, and relying on an internal representation of the sequence of trials. Twelve tetrodes were chronically implanted for single-unit recording in the right CA1 of each rat. We focus on 76 single neurons that showed significant activation during the fixation period compared with baseline activity between trials. Among these 76 fixation neurons, we observed 38 neurons that systematically changed their fixation activity as a function of the alternation sequence. That is, even though these rats were immobile during the fixation period, the neurons fired differently for trials in which the next spatial choice should be left (i.e., RIGHT-TO-LEFT trials) compared with trials in which the next spatial choice should be right (i.e., LEFT-TO-RIGHT trials), or vice versa. Our results imply that these neurons maintain a sequential code of the required spatial response during the alternation task and thus provide abstract information, derived from memory, that can be used for efficient navigation.

Decreased glutamate release correlates with elevated dynorphin content in the hippocampus of aged rats with spatial learning deficits

Hippocampus ◽  
1991 ◽  
Vol 1 (4) ◽  
pp. 391-397 ◽  
Author(s):  
Wan-Qin Zhang ◽  
William R. Mundy ◽  
Linda Thai ◽  
Pearlie M. Hudson ◽  
Michela Gallagher ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Glutamate Release ◽  
Aged Rats ◽  
Learning Deficits

Immunohistochemical and neurochemical correlates of learning deficits in aged rats

Neuroscience ◽  
2000 ◽  
Vol 96 (2) ◽  
pp. 275-289 ◽  
Author(s):  
J. Stemmelin ◽  
C. Lazarus ◽  
S. Cassel ◽  
C. Kelche ◽  
J.-C. Cassel
Keyword(s):  
Aged Rats ◽  
Learning Deficits ◽  
Neurochemical Correlates

scholarly journals Chronic estradiol replacement impairs performance on an operant delayed spatial alternation task in young, middle-aged, and old rats

2009 ◽  
Vol 56 (4) ◽  
pp. 382-390 ◽  
Author(s):  
Victor C. Wang ◽  
Steven L. Neese ◽  
Donna L. Korol ◽  
Susan L. Schantz
Keyword(s):  
Middle Aged ◽  
Spatial Alternation ◽  
Old Rats ◽  
Alternation Task

scholarly journals Memory Alone Does Not Account for the Way Rats Learn a Simple Spatial Alternation Task

2020 ◽  
Vol 40 (38) ◽  
pp. 7311-7317 ◽  
Author(s):  
David B. Kastner ◽  
Anna K. Gillespie ◽  
Peter Dayan ◽  
Loren M. Frank
Keyword(s):  
Spatial Alternation ◽  
Alternation Task ◽  
The Way
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