Decreased glutamate release correlates with elevated dynorphin content in the hippocampus of aged rats with spatial learning deficits

Hippocampus ◽  
1991 ◽  
Vol 1 (4) ◽  
pp. 391-397 ◽  
Author(s):  
Wan-Qin Zhang ◽  
William R. Mundy ◽  
Linda Thai ◽  
Pearlie M. Hudson ◽  
Michela Gallagher ◽  
...  
Keyword(s):  
Spatial Learning ◽  
Glutamate Release ◽  
Aged Rats ◽  
Learning Deficits

Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mahmoud Hashemzaei ◽  
Najmeh Baratzadeh ◽  
Iraj Sharamian ◽  
Sahar Fanoudi ◽  
Mehdi Sanati ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Spatial Memory ◽  
Morris Water Maze ◽  
Spatial Learning ◽  
Water Maze ◽  
Synergistic Effects ◽  
Deionized Water ◽  
Learning Deficits ◽  
Learning Impairments ◽  
Morris Water Maze Task

Abstract Objectives H-89 (a protein kinase AII [PKA II] inhibitor) impairs the spatial memory in the Morris water maze task in rats. In the present study, we aimed to study the protective effects of nicotine and O-acetyl-L-carnitine against H-89-induced spatial memory deficits. Methods Spatial memory impairment was induced by the bilateral intrahippocampal administration of 10 µM H-89 (dissolved in dimethyl sulfoxide, DMSO) to rats. The rats then received bilateral administrations of either nicotine (1 μg/μL, dissolved in saline) or O-acetyl-L-carnitine (100 μM/side, dissolved in deionized water) alone and in combination. Control groups received either saline, deionized water, or DMSO. Results The H-89-treated animals showed significant increases in the time and distance travelled to find hidden platforms, and there was also a significant decrease in the time spent in the target quadrant compared to DMSO-treated animals. Nicotine and O-acetyl-L-carnitine had no significant effects on H-89-induced spatial learning impairments alone, but the bilateral intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevented H-89-induced spatial learning deficits and increased the time spent in the target quadrant in comparison with H-89-treated animals. Conclusions Our results indicated the potential synergistic effects of nicotine and O-acetyl-L-carnitine in preventing protein kinase AII inhibitor (H-89)-induced spatial learning impairments.

Spatial Learning Deficits in Preschool Children of Alcoholics

1995 ◽  
Vol 19 (4) ◽  
pp. 1067-1072 ◽  
Author(s):  
Steven L. Schandler ◽  
Connie S. Thomas ◽  
Michael J. Cohen
Keyword(s):  
Preschool Children ◽  
Spatial Learning ◽  
Children Of Alcoholics ◽  
Learning Deficits

Mice lacking hippocampal left-right asymmetry show non-spatial learning deficits

2018 ◽  
Vol 336 ◽  
pp. 156-165 ◽  
Author(s):  
Akihiro Shimbo ◽  
Yutaka Kosaki ◽  
Isao Ito ◽  
Shigeru Watanabe
Keyword(s):  
Spatial Learning ◽  
Learning Deficits ◽  
Left Right Asymmetry

Age-related psychomotor and spatial learning deficits in 129/SvJ mice

1999 ◽  
Vol 20 (1) ◽  
pp. 9-18 ◽  
Author(s):  
John M Hengemihle ◽  
Jeffrey M Long ◽  
Jennifer Betkey ◽  
Mathias Jucker ◽  
Donald K Ingram
Keyword(s):  
Spatial Learning ◽  
Learning Deficits ◽  
Age Related

scholarly journals Spatial learning deficits following traumatic brain injury in rats: Reversal by bFGF

1998 ◽  
Vol 76 ◽  
pp. 193
Author(s):  
Hiroshi Uramoto ◽  
Shizuo Nakamura ◽  
Kyoshi Saitoh ◽  
Tomochika Ohno
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Spatial Learning ◽  
Learning Deficits

P3-065: THE BARNES MAZE TEST: A DRY LAND BEHAVIORAL TEST TO ANALYZE ALZHEIMER'S DISEASE MOUSE MODELS FOR SPATIAL LEARNING DEFICITS

2006 ◽  
Vol 14 (7S_Part_20) ◽  
pp. P1089-P1089
Author(s):  
Roland Rabl ◽  
Stephan Kurat ◽  
Iera Hernandez ◽  
Estibaliz Santiago-Mugica ◽  
Stefanie Flunkert ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Models ◽  
Spatial Learning ◽  
Barnes Maze ◽  
Behavioral Test ◽  
Learning Deficits ◽  
Dry Land ◽  
Maze Test
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