scholarly journals Psychological symptoms, smoking lapse behavior, and the mediating effects of nicotine withdrawal symptoms: A laboratory study.

2015 ◽  
Vol 29 (1) ◽  
pp. 71-81 ◽  
Author(s):  
Katherine J. Ameringer ◽  
Adam M. Leventhal
Keyword(s):  
Laboratory Study ◽  
Psychological Symptoms ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Mediating Effects ◽  
Smoking Lapse ◽  
Lapse Behavior

Momentary changes in craving predict smoking lapse behavior: a laboratory study

2018 ◽  
Vol 235 (7) ◽  
pp. 2001-2012 ◽  
Author(s):  
Courtney A. Motschman ◽  
Lisa J. Germeroth ◽  
Stephen T. Tiffany
Keyword(s):  
Laboratory Study ◽  
Smoking Lapse ◽  
Lapse Behavior

scholarly journals Association of frequency of perceived exposure to discrimination with tobacco withdrawal symptoms and smoking lapse behavior in African Americans

Addiction ◽  
2020 ◽  
Author(s):  
Mariel S. Bello ◽  
Madalyn M. Liautaud ◽  
Julianne T. De La Cerda ◽  
Raina D. Pang ◽  
Lara A. Ray ◽  
...  
Keyword(s):  
African Americans ◽  
Withdrawal Symptoms ◽  
Tobacco Withdrawal ◽  
Smoking Lapse ◽  
Tobacco Withdrawal Symptoms ◽  
Lapse Behavior

Does It Ever Go Away? Nicotine Withdrawal Symptoms One Year Post-Quit

2013 ◽  
Author(s):  
T. R. Schlam ◽  
M. E. Piper ◽  
J. W. Cook ◽  
M. C. Fiore ◽  
T. B. Baker
Keyword(s):  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
One Year

scholarly journals Acute effects of low and high dose alcohol on smoking lapse behavior in a laboratory analogue task

2014 ◽  
Vol 231 (24) ◽  
pp. 4649-4657 ◽  
Author(s):  
Christopher W. Kahler ◽  
Jane Metrik ◽  
Nichea S. Spillane ◽  
Anne Day ◽  
Adam M. Leventhal ◽  
...  
Keyword(s):  
High Dose ◽  
Acute Effects ◽  
Smoking Lapse ◽  
Laboratory Analogue ◽  
Lapse Behavior

Withania somnifera attenuates nicotine induced locomotor sensitization and withdrawal symptoms in mice

2018 ◽  
Vol 7 (2) ◽  
pp. 180-184
Author(s):  
Nitin G Dumore ◽  
◽  
Milind J Umekar ◽  
Brijrsh G Taksande ◽  
Manish M Aglawe ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Withania Somnifera ◽  
Anxiolytic Effect ◽  
Treated Group ◽  
Saline Group ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Locomotor Sensitization ◽  
Nicotine Treatment ◽  
Per Se

Objective: To investigate the effect of withania somnifera extract (WSE) on nicotine mediated reinforcement effect and withdrawal symptoms which attributed for the addiction liabilities of nicotine. Methods: In Swiss albino mice nicotine mediated locomotor sensitization and anxiogenic effects of chronic and acute nicotine treatment respectively was tested per se or in combination with WSE. In addition, nicotine withdrawal induced anxiety-like behavior was also studied. Locomotor sensitization was tested by employing open field test (OFT), while symptoms of anxiety were evaluated by subjecting mice to elevated plus maze (EPM). Results: Daily treatment with nicotine (subcutaneous) for 7 days showed gradual increase in the locomotor activity in OFT as compared to saline group indicating the development of locomotor sensitization. Following 3 days of drug free period, nicotine challenge on day 11 also showed rise in locomotor activity depicting expression of sensitization. WSE pretreatment inhibited the nicotine induced development and expression of locomotor sensitization. WSE+nicotine treated group showed decreased ambulations as compared to per se nicotine group on day 1-7 and day 8 (P<0.05). In EPM, acute nicotine treated mice spend more time in open arms as compared to saline indicating the anxiolytic behavior. WSE pretreatment reversed this anxiolytic effect. Nicotine withdrawal mice showed significant increase in the number of entries in arm and total time spend in closed arm indicating anxiety-like behavior. WSE treatment in nicotine withdrawal mice inhibited the nicotine withdrawal induced increased number of entries and time spend in closed arms. Conclusion: These results indicated that WSE may serve an effective herbal medicine in arresting nicotine mediated reinforcement and withdrawal signs

Anxiety, Depression, Psychological Symptoms, Negative Effects, and Other Symptoms of Nicotine Withdrawal

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ifdil Ifdil ◽  
Rima Pratiwi Fadli ◽  
Itsar Bolo Rangka ◽  
Kadek Suranata ◽  
Dominikus David Biondi Situmorang
Keyword(s):  
Psychological Symptoms ◽  
Nicotine Withdrawal ◽  
Negative Effects ◽  
Anxiety Depression

scholarly journals Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal

2018 ◽  
Vol 115 (16) ◽  
pp. 4282-4287 ◽  
Author(s):  
Julia K. Brynildsen ◽  
Bridgin G. Lee ◽  
Isaac J. Perron ◽  
Sunghee Jin ◽  
Sangwon F. Kim ◽  
...  
Keyword(s):  
United States ◽  
Smoking Cessation ◽  
The United States ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Ampk Activation ◽  
Ampk Signaling ◽  
Amp Activated Protein Kinase ◽  
Multiple Health ◽  
Withdrawal Signs

Cigarette smoking is the leading cause of preventable disease and death in the United States, with more persons dying from nicotine addiction than any other preventable cause of death. Even though smoking cessation incurs multiple health benefits, the abstinence rate remains low with current medications. Here we show that the AMP-activated protein kinase (AMPK) pathway in the hippocampus is activated following chronic nicotine use, an effect that is rapidly reversed by nicotine withdrawal. Increasing pAMPK levels and, consequently, downstream AMPK signaling pharmacologically attenuate anxiety-like behavior following nicotine withdrawal. We show that metformin, a known AMPK activator in the periphery, reduces withdrawal symptoms through a mechanism dependent on the presence of the AMPKα subunits within the hippocampus. This study provides evidence of a direct effect of AMPK modulation on nicotine withdrawal symptoms and suggests central AMPK activation as a therapeutic target for smoking cessation.

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