Anxiety sensitivity, acute nicotine withdrawal symptoms, and anxious and fearful responding to bodily sensations: A laboratory test.

2009 ◽  
Vol 17 (3) ◽  
pp. 181-190 ◽  
Author(s):  
Anka A. Vujanovic ◽  
Michael J. Zvolensky
Keyword(s):  
Laboratory Test ◽  
Anxiety Sensitivity ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Bodily Sensations

Reduction of anxiety sensitivity in relation to nicotine withdrawal symptoms during smoking cessation: an examination among successful quitters

2017 ◽  
Vol 47 (4) ◽  
pp. 301-314 ◽  
Author(s):  
Jafar Bakhshaie ◽  
Michael J. Zvolensky ◽  
Kirsten J. Langdon ◽  
Adam M. Leventhal ◽  
Norman B. Schmidt
Keyword(s):  
Smoking Cessation ◽  
Anxiety Sensitivity ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms

scholarly journals Anhedonia and Anxiety Sensitivity: Prospective Relationships to Nicotine Withdrawal Symptoms During Smoking Cessation

2013 ◽  
Vol 74 (3) ◽  
pp. 469-478 ◽  
Author(s):  
Kirsten J. Langdon ◽  
Adam M. Leventhal ◽  
Sherry Stewart ◽  
David Rosenfield ◽  
Dan Steeves ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Anxiety Sensitivity ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms

scholarly journals Anxiety sensitivity and pain-related anxiety in the prediction of fear responding to bodily sensations: A laboratory test

2011 ◽  
Vol 70 (3) ◽  
pp. 258-266 ◽  
Author(s):  
Adam Gonzalez ◽  
Michael J. Zvolensky ◽  
Julianna Hogan ◽  
Alison C. McLeish ◽  
Kristin S. Weibust
Keyword(s):  
Laboratory Test ◽  
Anxiety Sensitivity ◽  
Bodily Sensations

Acute nicotine withdrawal symptoms and anxious responding to bodily sensations: A test of incremental predictive validity among young adult regular smokers

2005 ◽  
Vol 43 (12) ◽  
pp. 1683-1700 ◽  
Author(s):  
Michael J. Zvolensky ◽  
Matthew T. Feldner ◽  
Ellen W. Leen-Feldner ◽  
Laura E. Gibson ◽  
Kenneth Abrams ◽  
...  
Keyword(s):  
Young Adult ◽  
Predictive Validity ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Bodily Sensations ◽  
Incremental Predictive Validity

Does It Ever Go Away? Nicotine Withdrawal Symptoms One Year Post-Quit

2013 ◽  
Author(s):  
T. R. Schlam ◽  
M. E. Piper ◽  
J. W. Cook ◽  
M. C. Fiore ◽  
T. B. Baker
Keyword(s):  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
One Year

Withania somnifera attenuates nicotine induced locomotor sensitization and withdrawal symptoms in mice

2018 ◽  
Vol 7 (2) ◽  
pp. 180-184
Author(s):  
Nitin G Dumore ◽  
◽  
Milind J Umekar ◽  
Brijrsh G Taksande ◽  
Manish M Aglawe ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Withania Somnifera ◽  
Anxiolytic Effect ◽  
Treated Group ◽  
Saline Group ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Locomotor Sensitization ◽  
Nicotine Treatment ◽  
Per Se

Objective: To investigate the effect of withania somnifera extract (WSE) on nicotine mediated reinforcement effect and withdrawal symptoms which attributed for the addiction liabilities of nicotine. Methods: In Swiss albino mice nicotine mediated locomotor sensitization and anxiogenic effects of chronic and acute nicotine treatment respectively was tested per se or in combination with WSE. In addition, nicotine withdrawal induced anxiety-like behavior was also studied. Locomotor sensitization was tested by employing open field test (OFT), while symptoms of anxiety were evaluated by subjecting mice to elevated plus maze (EPM). Results: Daily treatment with nicotine (subcutaneous) for 7 days showed gradual increase in the locomotor activity in OFT as compared to saline group indicating the development of locomotor sensitization. Following 3 days of drug free period, nicotine challenge on day 11 also showed rise in locomotor activity depicting expression of sensitization. WSE pretreatment inhibited the nicotine induced development and expression of locomotor sensitization. WSE+nicotine treated group showed decreased ambulations as compared to per se nicotine group on day 1-7 and day 8 (P<0.05). In EPM, acute nicotine treated mice spend more time in open arms as compared to saline indicating the anxiolytic behavior. WSE pretreatment reversed this anxiolytic effect. Nicotine withdrawal mice showed significant increase in the number of entries in arm and total time spend in closed arm indicating anxiety-like behavior. WSE treatment in nicotine withdrawal mice inhibited the nicotine withdrawal induced increased number of entries and time spend in closed arms. Conclusion: These results indicated that WSE may serve an effective herbal medicine in arresting nicotine mediated reinforcement and withdrawal signs

scholarly journals Activation of AMPK by metformin improves withdrawal signs precipitated by nicotine withdrawal

2018 ◽  
Vol 115 (16) ◽  
pp. 4282-4287 ◽  
Author(s):  
Julia K. Brynildsen ◽  
Bridgin G. Lee ◽  
Isaac J. Perron ◽  
Sunghee Jin ◽  
Sangwon F. Kim ◽  
...  
Keyword(s):  
United States ◽  
Smoking Cessation ◽  
The United States ◽  
Nicotine Withdrawal ◽  
Withdrawal Symptoms ◽  
Ampk Activation ◽  
Ampk Signaling ◽  
Amp Activated Protein Kinase ◽  
Multiple Health ◽  
Withdrawal Signs

Cigarette smoking is the leading cause of preventable disease and death in the United States, with more persons dying from nicotine addiction than any other preventable cause of death. Even though smoking cessation incurs multiple health benefits, the abstinence rate remains low with current medications. Here we show that the AMP-activated protein kinase (AMPK) pathway in the hippocampus is activated following chronic nicotine use, an effect that is rapidly reversed by nicotine withdrawal. Increasing pAMPK levels and, consequently, downstream AMPK signaling pharmacologically attenuate anxiety-like behavior following nicotine withdrawal. We show that metformin, a known AMPK activator in the periphery, reduces withdrawal symptoms through a mechanism dependent on the presence of the AMPKα subunits within the hippocampus. This study provides evidence of a direct effect of AMPK modulation on nicotine withdrawal symptoms and suggests central AMPK activation as a therapeutic target for smoking cessation.

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