scholarly journals Sex differences in the relative influence of marital status and parenthood on alcohol use disorder symptoms: A multilevel discordant twin design.

2020 ◽  
Vol 129 (7) ◽  
pp. 737-747
Author(s):  
Genevieve F. Dash ◽  
Nicholas G. Martin ◽  
Michael T. Lynskey ◽  
Wendy S. Slutske
Keyword(s):  
Sex Differences ◽  
Alcohol Use ◽  
Marital Status ◽  
Alcohol Use Disorder ◽  
Relative Influence ◽  
Twin Design ◽  
Discordant Twin

scholarly journals From alcohol initiation to tolerance to problems: Discordant twin modeling of a developmental process

2016 ◽  
Vol 29 (3) ◽  
pp. 845-861 ◽  
Author(s):  
Arielle R. Deutsch ◽  
Wendy S. Slutske ◽  
Michael T. Lynskey ◽  
Kathleen K. Bucholz ◽  
Pamela A. F. Madden ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Developmental Process ◽  
Age Of Onset ◽  
Causal Effect ◽  
Time To Event ◽  
Twin Design ◽  
Time Period ◽  
Disorder Symptom ◽  
Discordant Twin

AbstractThe current study examined a stage-based alcohol use trajectory model to test for potential causal effects of earlier drinking milestones on later drinking milestones in a combined sample of two cohorts of Australian monozygotic and same-sex dizygotic twins (N= 7,398, ageM= 30.46,SD= 2.61, 61% male, 56% monozygotic twins). Ages of drinking, drunkenness, regular drinking, tolerance, first nontolerance alcohol use disorder symptom, and alcohol use disorder symptom onsets were assessed retrospectively. Ages of milestone attainment (i.e., age-of-onset) and time between milestones (i.e., time-to-event) were examined via frailty models within a multilevel discordant twin design. For age-of-onset models, earlier ages of onset of antecedent drinking milestones increased hazards for earlier ages of onset for more proximal subsequent drinking milestones. For the time-to-event models, however, earlier ages of onset for the “starting” milestone decreased risk for a shorter time period between the starting and the “ending” milestone. Earlier age of onset of intermediate milestones between starting and ending drinking milestones had the opposite effect, increasing risk for a shorter time period between the starting and ending milestones. These results are consistent with a causal effect of an earlier age of drinking milestone onset on temporally proximal subsequent drinking milestones.

scholarly journals An Initial Investigation of Disrupted Intracortical Myelin as a Novel Brain Marker of Alcohol Use Disorder

2020 ◽  
Author(s):  
Vanessa Morris ◽  
Luciano Minuzzi ◽  
Nicholas Bock ◽  
James MacKillop ◽  
Michael Amlung
Keyword(s):  
Sex Differences ◽  
Prefrontal Cortex ◽  
Alcohol Use ◽  
Gray Matter ◽  
Alcohol Use Disorder ◽  
A Priori ◽  
Anterior Cingulate ◽  
Posterior Cingulate ◽  
Cohen’S D ◽  
Cohen's D

Abstract: Although disruption of cortical gray matter and white matter tracts are well-established markers of alcohol use disorder (AUD), this is the first study to examine the specific role of intracortical myelin (ICM; i.e., highly myelinated gray matter in deeper cortical layers) in AUD. The current study used a 3T MRI sequence optimized for high intracortical contrast to examine patterns of ICM-related MRI signal in 30 individuals with AUD and 33 healthy social drinkers. Secondary aims included exploring continuous associations with alcohol problem severity and examining sex differences. Surface-based analytic techniques were used to quantify ICM-related MRI signal for a priori region of interest analyses (20 bilateral regions) and exploratory vertex-wise analyses (using Cohen’s d). Although the distribution of ICM-related signal was generally comparable between groups, the AUD group exhibited significantly (p<.05) greater ICM-related MRI signal in precuneus, ventromedial prefrontal cortex, posterior cingulate, middle anterior cingulate, middle/posterior insula, dorsolateral prefrontal cortex, and posterior cingulate, among other regions (Cohen’s d = .50-.75, indicating medium magnitude effects). Significant positive correlations between ICM signal and AUD severity were found in several frontal, parietal, cingulate, and temporal regions (rs .25-.34). No sex differences in ICM were observed. These findings provide initial proof-of-concept for examining ICM in relation to AUD. Understanding the pathophysiological mechanisms of these associations (e.g., neuroinflammation) and the clinical relevance of ICM is warranted.

Sex Differences in Alcohol Use Disorder

2017 ◽  
Vol 24 (24) ◽  
Author(s):  
Roberta Agabio ◽  
Claudia Pisanu ◽  
Gian Luigi Gessa ◽  
Flavia Franconi
Keyword(s):  
Sex Differences ◽  
Alcohol Use ◽  
Alcohol Use Disorder

scholarly journals Prevalence of Relapse of Alcohol Use Disorder and the Association With Self-Efficacy and Perceived Social Support in Butabika Hospital

2021 ◽  
Author(s):  
Kenneth Kalani ◽  
Janet Nakigudde ◽  
Caroline Birungi ◽  
Joy Gumikiriza- Onoria ◽  
Nelson Mukiza ◽  
...  
Keyword(s):  
Social Support ◽  
Alcohol Use ◽  
Marital Status ◽  
Self Efficacy ◽  
Alcohol Use Disorder ◽  
Perceived Social Support ◽  
Multivariable Analysis ◽  
Sub Saharan Africa ◽  
P Value ◽  
Study Objective

Abstract Background Alcohol use disorder (AUD) is a problem globally and Uganda has one of the highest per capita alcohol consumption rates in sub-Saharan Africa. Relapse is a distressing aspect in the treatment of AUD and it is mediated by self-efficacy and perceived social support besides other psychosocial factors. In Uganda, there is paucity of data regarding relapse of AUD and the association with self-efficacy and perceived social support hence the need to carry out this study. Objective To determine the prevalence of relapse of AUD and the association with self-efficacy and perceived social support at Butabika hospital. Methods A cross-sectional study design was used and 269 participants that received treatment for AUD at hospital in the period between 1st /01/2016 and 31st /12/2017 were consecutively recruited. Participants were assessed for relapse of AUD using the SCID-5 substance use disorder section. Data was collected using a socio-demographic questionnaire, the general self-efficacy scale and the multidimensional scale for perceived social support. Data was entered in Epidata 3.0 and imported into STATA version 14 for analysis. Chi square test and logistic regression were used at bi-variable and multivariable analysis respectively to determine associations. Results The prevalence of relapse of AUD among the 269 participants was 63.3% (170). Of those who relapsed, 98% (167) had severe AUD. Participants with a marital status of single were less likely to relapse into alcohol use than those with a marital status of; separated or divorced (OR = 6.81; 95% CI = 1.53–30.32; p-value = 0.012) and married (OR = 2.86; 95% CI = 1.07–7.65; p-value = 0.037). Male participants were more likely to relapse into AUD than the females (OR = 0.19; 95%CI = 0.04–0.86; p-value = 0.03). Participants with higher perceived social support (OR = 0.85; 95% CI = 0.81–0.9; p-value = < 0.001) were less likely to relapse into AUD. Self-efficacy (OR = 0.93; 95% CI = 0.85-1; p-value = 0.061) was not significantly associated with relapse of AUD. Conclusion The prevalence of relapse of AUD is high and is associated with perceived social support, marital status of; separated, divorced or married, and female gender. Relapse prevention programs should emphasize the importance of social support in the management of patients with AUD. Further research to assess the relationship between relapse of AUD among married people is recommended.

Sex Differences in the Associations Between Symptom Severity, Social Cognition, and Social Brain Network Connectivity in Alcohol Use Disorder

2020 ◽  
Author(s):  
Abigail Waters ◽  
Sergey Chernyak ◽  
Amy Janes ◽  
William Killgore ◽  
Shelly Greenfield ◽  
...  
Keyword(s):  
Sex Differences ◽  
Social Cognition ◽  
Alcohol Use ◽  
Symptom Severity ◽  
Alcohol Use Disorder ◽  
Brain Networks ◽  
Network Connectivity ◽  
Brain Network ◽  
Men And Women ◽  
Brain Network Connectivity

Background and Aims: Large-scale neurocognitive brain networks are necessary to coordinate social cognition. Regions of prefrontal cortex that are key nodes in these networks are highly vulnerable to alcohol neurotoxicity, which may link poor social function and alcohol use disorder (AUD). However, there is very little research on how brain networks associated with social cognition are affected by AUD, and no studies of how these effects may differ between men and women. The current study aims to address this gap by examining the interaction between sex and AUD on the connectivity between brain networks implicated in social cognition.Methods: Matched groups of men and women with and without AUD (N=156; N=39/group) were selected from the Human Connectome Project. Resting-state functional magnetic resonance imaging data were used to compute functional connectivity between prefrontal networks, including default mode sub-networks (anterior dorsomedial: aDMN, ventromedial: vmDMN, temporal lobe: tDMN, and posterior DMN: pDMN), and central executive, dorsal attention, ventral attention, salience, and striatal networks. Between-network connectivity was assessed for interactions between sex, AUD diagnosis and symptom severity, and a measure of composite social cognition using non-parametric permutation testing, corrected for number of network pairs tested (Benjamini-Hochberg procedure, p&lt;0.05 corrected). Results: Connectivity between aDMN–tDMN (AUDcontrols, pcor=.030) differed between groups. An interaction between sex and AUD symptom severity was significantly associated with aDMN–VAN (pcor= .032) connectivity. Social cognition scores were associated with aDMN–vmDMN connectivity (pcor=.003), with the relationship being moderated by sex, AUD-status, and symptom severity. Conclusions: This study addresses a critical gap in the literature on how brain network connectivity that underpins social cognition may be impaired in men and women with AUD. Our findings show that vulnerabilities emerge in men and women even at mild symptom severity and that there are significant sex differences, suggesting sex-specific treatment considerations are warranted.

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