scholarly journals Sex differences in the latent class structure of alcohol use disorder: Does (dis)aggregation of indicators matter?

2015 ◽  
Vol 23 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Emilie M. Shireman ◽  
Douglas Steinley ◽  
Kenneth Sher
Keyword(s):  
Sex Differences ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Latent Class ◽  
Class Structure

scholarly journals Towards the characterization and validation of alcohol use disorder subtypes: integrating consumption and symptom data

2013 ◽  
Vol 44 (1) ◽  
pp. 143-159 ◽  
Author(s):  
K. M. Jackson ◽  
K. K. Bucholz ◽  
P. K. Wood ◽  
D. Steinley ◽  
J. D. Grant ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Alcohol Use ◽  
Alcohol Use Disorder ◽  
Model Comparison ◽  
Latent Class ◽  
Common Factor ◽  
Hybrid Approaches ◽  
Epidemiologic Survey ◽  
Alcohol Involvement ◽  
Best Fitting

BackgroundThere is evidence that measures of alcohol consumption, dependence and abuse are valid indicators of qualitatively different subtypes of alcohol involvement yet also fall along a continuum. The present study attempts to resolve the extent to which variations in alcohol involvement reflect a difference in kindversusa difference in degree.MethodData were taken from the 2001–2002 National Epidemiologic Survey of Alcohol and Related Conditions. The sample (51% male; 72% white/non-Hispanic) included respondents reporting past 12-month drinking at both waves (wave 1:n = 33644; wave 2:n = 25186). We compared factor mixture models (FMMs), a hybrid of common factor analysis (FA) and latent class analysis (LCA), against FA and LCA models using past 12-month alcohol use disorder (AUD) criteria and five indicators of alcohol consumption reflecting frequency and heaviness of drinking.ResultsModel comparison revealed that the best-fitting model at wave 1 was a one-factor four-class FMM, with classes primarily varying across dependence and consumption indices. The model was replicated using wave 2 data, and validated against AUD and dependence diagnoses. Class stability from waves 1 to 2 was moderate, with greatest agreement for the infrequent drinking class. Within-class associations in the underlying latent factor also revealed modest agreement over time.ConclusionsThere is evidence that alcohol involvement can be considered both categorical and continuous, with responses reduced to four patterns that quantitatively vary along a single dimension. Nosologists may consider hybrid approaches involving groups that vary in pattern of consumption and dependence symptomatology as well as variation of severity within group.

scholarly journals An Initial Investigation of Disrupted Intracortical Myelin as a Novel Brain Marker of Alcohol Use Disorder

2020 ◽  
Author(s):  
Vanessa Morris ◽  
Luciano Minuzzi ◽  
Nicholas Bock ◽  
James MacKillop ◽  
Michael Amlung
Keyword(s):  
Sex Differences ◽  
Prefrontal Cortex ◽  
Alcohol Use ◽  
Gray Matter ◽  
Alcohol Use Disorder ◽  
A Priori ◽  
Anterior Cingulate ◽  
Posterior Cingulate ◽  
Cohen’S D ◽  
Cohen's D

Abstract: Although disruption of cortical gray matter and white matter tracts are well-established markers of alcohol use disorder (AUD), this is the first study to examine the specific role of intracortical myelin (ICM; i.e., highly myelinated gray matter in deeper cortical layers) in AUD. The current study used a 3T MRI sequence optimized for high intracortical contrast to examine patterns of ICM-related MRI signal in 30 individuals with AUD and 33 healthy social drinkers. Secondary aims included exploring continuous associations with alcohol problem severity and examining sex differences. Surface-based analytic techniques were used to quantify ICM-related MRI signal for a priori region of interest analyses (20 bilateral regions) and exploratory vertex-wise analyses (using Cohen’s d). Although the distribution of ICM-related signal was generally comparable between groups, the AUD group exhibited significantly (p<.05) greater ICM-related MRI signal in precuneus, ventromedial prefrontal cortex, posterior cingulate, middle anterior cingulate, middle/posterior insula, dorsolateral prefrontal cortex, and posterior cingulate, among other regions (Cohen’s d = .50-.75, indicating medium magnitude effects). Significant positive correlations between ICM signal and AUD severity were found in several frontal, parietal, cingulate, and temporal regions (rs .25-.34). No sex differences in ICM were observed. These findings provide initial proof-of-concept for examining ICM in relation to AUD. Understanding the pathophysiological mechanisms of these associations (e.g., neuroinflammation) and the clinical relevance of ICM is warranted.

scholarly journals A latent class analysis of alcohol and posttraumatic stress symptoms among offspring of parents with and without alcohol use disorder

2021 ◽  
Vol 112 ◽  
pp. 106640
Author(s):  
Annah K. Bender ◽  
Jacquelyn L. Meyers ◽  
Stacey Subbie-Saenz di Viteri ◽  
Marc Schuckit ◽  
Grace Chan ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Latent Class Analysis ◽  
Posttraumatic Stress ◽  
Alcohol Use Disorder ◽  
Latent Class ◽  
Posttraumatic Stress Symptoms ◽  
Class Analysis ◽  
Stress Symptoms

Sex Differences in Alcohol Use Disorder

2017 ◽  
Vol 24 (24) ◽  
Author(s):  
Roberta Agabio ◽  
Claudia Pisanu ◽  
Gian Luigi Gessa ◽  
Flavia Franconi
Keyword(s):  
Sex Differences ◽  
Alcohol Use ◽  
Alcohol Use Disorder

scholarly journals Impaired control in heavy drinking and its association with alcohol craving and alcohol use disorder severity

Salud Mental ◽  
2020 ◽  
Vol 43 (4) ◽  
pp. 151-157
Author(s):  
Edén Sánchez ◽  
Carlos S. Cruz Fuentes ◽  
Corina Benjet ◽  
María Elena Medina-Mora
Keyword(s):  
Alcohol Use ◽  
Alcohol Dependence ◽  
Perceived Control ◽  
Alcohol Use Disorder ◽  
Latent Class ◽  
Heavy Drinking ◽  
Alcohol Craving ◽  
Heavy Drinkers ◽  
Impaired Control ◽  
The Relationship

Introduction. Impaired control over drinking has been frequently cited in diverse theoretical descriptions regarding harmful alcohol use and is considered a DSM criterion for alcohol use disorder. Differences in the frequency of endorsement of impaired control have been viewed as a reflection of the severity of the problem. Moreover, it has been posited that the ability to place a limit on alcohol consumption may be mediated through enhanced craving. Objective. In this study, we addressed the relationship between impaired control, self-reported craving, and alcohol dependence severity among heavy drinkers. Method. We conducted a latent class analysis of impaired control dimensions (perceived control, failed control, and attempted control) of 208 heavy drinkers. To determine whether the identified classes could represent different forms of severity of the disorder, the best-fit model was contrasted with scores on the Alcohol Dependence Scale. Furthermore, we assessed the relationship between impaired control criteria (using the Impaired Control Scale [ICS]) with alcohol craving. Results. We identified a three-class solution based on impaired control severity. A graded increase of the craving scores and alcohol severity among the three classes was also identified. Only the ICS items comprising perceived control and partially those related to failed control, but not those evaluating attempted control, distinguished the gradient among the latent classes. Discussion and conclusion. This study provides further support of the proposal of a unidimensional continuum of severity among heavy drinkers and strengthens the theoretical relationship between impaired control and alcohol craving.

Sign in / Sign up

Export Citation Format

Share Document