Cognitive ability, intraindividual variability, and common genetic variants of catechol-O-methyltransferase and brain-derived neurotrophic factor: A longitudinal study in a population-based sample of older adults.

2014 ◽  
Vol 29 (2) ◽  
pp. 393-403 ◽  
Author(s):  
Debjani Das ◽  
Xiaoyun Tan ◽  
Allison A. M. Bielak ◽  
Nicolas Cherbuin ◽  
Simon Easteal ◽  
...  
Keyword(s):  
Older Adults ◽  
Longitudinal Study ◽  
Cognitive Ability ◽  
Neurotrophic Factor ◽  
Genetic Variants ◽  
Brain Derived Neurotrophic Factor ◽  
Population Based ◽  
Intraindividual Variability ◽  
Common Genetic Variants

scholarly journals The Val/Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene predicts decline in perceptual speed in older adults.

2014 ◽  
Vol 29 (2) ◽  
pp. 384-392 ◽  
Author(s):  
Paolo Ghisletta ◽  
Lars Bäckman ◽  
Lars Bertram ◽  
Andreas Markus Brandmaier ◽  
Denis Gerstorf ◽  
...  
Keyword(s):  
Older Adults ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Perceptual Speed ◽  
Bdnf Gene ◽  
The Brain

Brain-derived neurotrophic factor genetic variants are not susceptibility factors to Alzheimer's disease in Italy

2004 ◽  
Vol 55 (3) ◽  
pp. 447-448 ◽  
Author(s):  
Silvia Bagnoli ◽  
Benedetta Nacmias ◽  
Andrea Tedde ◽  
Bianca Maria Guarnieri ◽  
Elena Cellini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurotrophic Factor ◽  
Genetic Variants ◽  
Brain Derived Neurotrophic Factor ◽  
Susceptibility Factors

Low brain-derived neurotrophic factor levels in post-mortem brains of older adults with depression and dementia in a large clinicopathological sample.

2018 ◽  
Vol 241 ◽  
pp. 176-181 ◽  
Author(s):  
Paula Villela Nunes ◽  
Camila Fernandes Nascimento ◽  
Helena Kyunghee Kim ◽  
Ana Cristina Andreazza ◽  
Helena Paula Brentani ◽  
...  
Keyword(s):  
Older Adults ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Post Mortem

The Brain-Derived Neurotrophic Factor Functional Polymorphism and Hand Grip Strength Impact the Association between Brain-Derived Neurotrophic Factor Levels and Cognition in Older Adults in the United States

2022 ◽  
pp. 109980042110651
Author(s):  
Tingting Liu ◽  
Hongjin Li ◽  
Yvette P. Conley ◽  
Brian A. Primack ◽  
Jing Wang ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Grip Strength ◽  
Mental Status ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Hand Grip Strength ◽  
Hand Grip ◽  
Serum Bdnf

Introduction Aging is associated with subtle cognitive decline in attention, memory, executive function, processing speed, and reasoning. Although lower brain-derived neurotrophic factor (BDNF) has been linked to cognitive decline among older adults, it is not known if the association differs among individuals with various BDNF Val66Met (rs6265) genotypes. In addition, it is not clear whether these associations vary by hand grip strength or physical activity (PA). Methods A total of 2904 older adults were included in this study using data from the Health and Retirement Study. Associations between serum BDNF and measures of cognitive function were evaluated using multivariable linear regression models stratified by Met allele status. PA and hand grip strength were added to the model to evaluate whether including these variables altered associations between serum BDNF and cognition. Results Mean age was 71.4 years old, and mean body mass index was 28.3 kg/m2. Serum BDNF levels were positively associated with higher total cognitive score (beta = 0.34, p = .07), mental status (beta = 0.16, p = .07), and word recall (beta = 0.22, p =.04) among Met carriers, while serum BDNF levels were negatively associated with mental status (beta = −0.09, p = .07) among non-Met carriers. Furthermore, associations changed when hand grip strength was added to the model but not when PA was added to the model. Conclusions The BDNF Val66Met variant may moderate the association between serum BDNF levels and cognitive function in older adults. Furthermore, such associations differ according to hand grip strength but not PA.

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