Low brain-derived neurotrophic factor levels in post-mortem brains of older adults with depression and dementia in a large clinicopathological sample.

2018 ◽  
Vol 241 ◽  
pp. 176-181 ◽  
Author(s):  
Paula Villela Nunes ◽  
Camila Fernandes Nascimento ◽  
Helena Kyunghee Kim ◽  
Ana Cristina Andreazza ◽  
Helena Paula Brentani ◽  
...  
Keyword(s):  
Older Adults ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Post Mortem

scholarly journals The Val/Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene predicts decline in perceptual speed in older adults.

2014 ◽  
Vol 29 (2) ◽  
pp. 384-392 ◽  
Author(s):  
Paolo Ghisletta ◽  
Lars Bäckman ◽  
Lars Bertram ◽  
Andreas Markus Brandmaier ◽  
Denis Gerstorf ◽  
...  
Keyword(s):  
Older Adults ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Perceptual Speed ◽  
Bdnf Gene ◽  
The Brain

The Brain-Derived Neurotrophic Factor Functional Polymorphism and Hand Grip Strength Impact the Association between Brain-Derived Neurotrophic Factor Levels and Cognition in Older Adults in the United States

2022 ◽  
pp. 109980042110651
Author(s):  
Tingting Liu ◽  
Hongjin Li ◽  
Yvette P. Conley ◽  
Brian A. Primack ◽  
Jing Wang ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Grip Strength ◽  
Mental Status ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Hand Grip Strength ◽  
Hand Grip ◽  
Serum Bdnf

Introduction Aging is associated with subtle cognitive decline in attention, memory, executive function, processing speed, and reasoning. Although lower brain-derived neurotrophic factor (BDNF) has been linked to cognitive decline among older adults, it is not known if the association differs among individuals with various BDNF Val66Met (rs6265) genotypes. In addition, it is not clear whether these associations vary by hand grip strength or physical activity (PA). Methods A total of 2904 older adults were included in this study using data from the Health and Retirement Study. Associations between serum BDNF and measures of cognitive function were evaluated using multivariable linear regression models stratified by Met allele status. PA and hand grip strength were added to the model to evaluate whether including these variables altered associations between serum BDNF and cognition. Results Mean age was 71.4 years old, and mean body mass index was 28.3 kg/m2. Serum BDNF levels were positively associated with higher total cognitive score (beta = 0.34, p = .07), mental status (beta = 0.16, p = .07), and word recall (beta = 0.22, p =.04) among Met carriers, while serum BDNF levels were negatively associated with mental status (beta = −0.09, p = .07) among non-Met carriers. Furthermore, associations changed when hand grip strength was added to the model but not when PA was added to the model. Conclusions The BDNF Val66Met variant may moderate the association between serum BDNF levels and cognitive function in older adults. Furthermore, such associations differ according to hand grip strength but not PA.

Decreased Brain-Derived Neurotrophic Factor in Older Adults with Bipolar Disorder

2016 ◽  
Vol 24 (8) ◽  
pp. 596-601 ◽  
Author(s):  
Aline T. Soares ◽  
Ana C. Andreazza ◽  
Soham Rej ◽  
Tarek K. Rajji ◽  
Ariel G. Gildengers ◽  
...  
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals The brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism affects memory performance in older adults

2017 ◽  
Vol 39 (2) ◽  
pp. 90-94 ◽  
Author(s):  
Lucas A. de Azeredo ◽  
Tatiana De Nardi ◽  
Mateus L. Levandowski ◽  
Saulo G. Tractenberg ◽  
Julia Kommers-Molina ◽  
...  
Keyword(s):  
Older Adults ◽  
Neurotrophic Factor ◽  
Memory Performance ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Val66met Polymorphism ◽  
The Brain

P4-071: APOLIPOPROTEIN E-ɛ4 MODULATES EFFECTS OF AEROBIC EXERCISE ON BRAIN-DERIVED NEUROTROPHIC FACTOR LEVELS IN NON-DEMENTED OLDER ADULTS

2014 ◽  
Vol 10 ◽  
pp. P809-P809
Author(s):  
Jessica Rodrigues Pereira ◽  
Carla Nascimento ◽  
Larissa Andrade ◽  
Marcelo Garuffi ◽  
Daniel Shikanai Kerr ◽  
...  
Keyword(s):  
Older Adults ◽  
Apolipoprotein E ◽  
Aerobic Exercise ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor
Sign in / Sign up

Export Citation Format

Share Document