The effects of lesions of the hippocampus or orbitofrontal cortex on an operant box based intertemporal choice task in mice.

2011 ◽  
Vol 4 (4) ◽  
pp. 217-234 ◽  
Author(s):  
Beate C. Finger ◽  
Robert M. J. Deacon ◽  
Peter Burns ◽  
Thomas G. Campbell
Keyword(s):  
Orbitofrontal Cortex ◽  
Intertemporal Choice ◽  
Choice Task

Single dose testosterone administration increases impulsivity in the intertemporal choice task among healthy males

2020 ◽  
Vol 118 ◽  
pp. 104634 ◽  
Author(s):  
Yin Wu ◽  
Bo Shen ◽  
Jiajun Liao ◽  
Yansong Li ◽  
Samuele Zilioli ◽  
...  
Keyword(s):  
Single Dose ◽  
Intertemporal Choice ◽  
Choice Task ◽  
Testosterone Administration ◽  
Healthy Males

scholarly journals Differential encoding of action selection by orbitofrontal and striatal population dynamics

2020 ◽  
Vol 124 (2) ◽  
pp. 634-644
Author(s):  
Long Yang ◽  
Sotiris C. Masmanidis
Keyword(s):  
Population Dynamics ◽  
Orbitofrontal Cortex ◽  
Action Selection ◽  
Choice Task ◽  
Previous Literature ◽  
Neural Signals ◽  
Population Activity ◽  
Differential Encoding ◽  
Alternative Choice ◽  
Dorsomedial Striatum

While previous literature shows that both orbitofrontal cortex (OFC) and dorsomedial striatum (DMS) represent information relevant to selecting specific actions, few studies have directly compared neural signals between these areas. Here we compared OFC and DMS dynamics in mice performing a two-alternative choice task. We found that the animal’s choice could be decoded more accurately from DMS population activity. This work provides among the first evidence that OFC and DMS differentially represent information about an animal’s selected action.

scholarly journals Increased Capacity to Delay Reward in Anorexia Nervosa

2012 ◽  
Vol 18 (4) ◽  
pp. 773-780 ◽  
Author(s):  
Joanna E. Steinglass ◽  
Bernd Figner ◽  
Staci Berkowitz ◽  
H. Blair Simpson ◽  
Elke U. Weber ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Food Restriction ◽  
Intertemporal Choice ◽  
Temporal Discounting ◽  
Choice Task ◽  
Reward Processing ◽  
Self Control ◽  
Life Threatening ◽  
Neuropsychological Characteristics ◽  
Secondary Analyses

AbstractIndividuals with anorexia nervosa (AN) are often characterized as possessing excessive self-control and are unusual in their ability to reduce or avoid the consumption of palatable foods. This behavior promotes potentially life-threatening weight loss and suggests disturbances in reward processing. We studied whether individuals with AN showed evidence of increased self-control by examining the tendency to delay receipt of a monetary, non-food related, reward. Underweight AN (n = 36) and healthy controls (HC, n = 28) completed a monetary intertemporal choice task measuring delay discounting factor. Individuals with AN reduced the value of a monetary reward over time significantly less than HC (F[1,61] = 5.03; p = 0.029). Secondary analyses indicated that the restricting subtype of AN, in particular, showed significantly less discounting than HC (F[1,46] = 8.3; p = 0.006). These findings indicate that some individuals with AN show less temporal discounting than HC, suggestive of enhanced self-control that is not limited to food consumption. This is in contrast to other psychiatric disorders, for example, substance abuse, which are characterized by greater discounting. Though preliminary, these findings suggest that excessive self-control may contribute to pathological processes and individuals with AN may have neuropsychological characteristics that enhance their ability to delay reward and thereby may help to maintain persistent food restriction. (JINS, 2012, 18, 1–8)

scholarly journals Shared neuronal bases of inhibition and economic choice in orbitofrontal cortex

2020 ◽  
Author(s):  
Pragathi Priyadharsini Balasubramani ◽  
Benjamin Y. Hayden
Keyword(s):  
Neural Network ◽  
Inhibitory Control ◽  
Neuronal Activity ◽  
Orbitofrontal Cortex ◽  
Choice Task ◽  
Stop Signal Task ◽  
Economic Choice ◽  
Brain Circuits ◽  
Neural Processes ◽  
Theoretical Unification

ABSTRACTEconomic choice and inhibition are two important elements of our cognitive repertoires that may be closely related. We and others have noted that during economic choice, options are typically considered serially; this fact provides important constraints on our understanding of choice. Notably, asynchronous contemplation means that each individual option is subject to an accept-reject decision. We have proposed that these component accept-reject decisions may have some kinship with stopping decisions. One prediction of this idea is that stopping and choice may reflect similar neural processes occurring in overlapping brain circuits. To test the idea, we recorded neuronal activity in orbitofrontal cortex (OFC) Area 13 while macaques performed a stop signal task interleaved with a structurally matched choice task. Using neural network decoders, we find that OFC ensembles have overlapping codes for stopping and choice: the decoder that was only trained to identify accept vs. reject trials performed with higher efficiency even when tested on the stop trials. These results provide tentative support for the idea that mechanisms underlying inhibitory control and choice selection may be subject to theoretical unification.

No evidence for the involvement of serotonin or the 5-HTTLPR genotype in intertemporal choice in a larger community sample

2019 ◽  
Vol 33 (11) ◽  
pp. 1377-1387
Author(s):  
Philipp T Neukam ◽  
Yacila I Deza-Araujo ◽  
Michael Marxen ◽  
Shakoor Pooseh ◽  
Marcella Rietschel ◽  
...  
Keyword(s):  
Animal Studies ◽  
Intertemporal Choice ◽  
Community Sample ◽  
Temporal Discounting ◽  
Blood Oxygen Level Dependent ◽  
Choice Task ◽  
Blood Oxygen Level ◽  
Double Blind ◽  
Theoretical Approaches ◽  
S Allele

Background: Serotonin has been implicated in impulsive behaviours such as temporal discounting. While animal studies and theoretical approaches suggest that reduced tonic serotonin levels increase temporal discounting rates and vice versa, evidence from human studies is scarce and inconclusive. Furthermore, an important modulator of serotonin signalling, a genetic variation in the promoter region of the serotonin transporter gene ( 5-HTTLPR), has not been investigated for temporal discounting so far. Objective: First, the purpose of this study was to test for a significant association between 5-HTTLPR and temporal discounting. Second, we wished to investigate the effect of high/low tonic serotonin levels on intertemporal choice and blood oxygen-level-dependent response, controlling for 5-HTTLPR. Methods: We tested the association of 5-HTTLPR with temporal discounting rates using an intertemporal choice task in 611 individuals. We then manipulated tonic serotonin levels with acute tryptophan interventions (depletion, loading, balanced) in a subsample of 45 short (S)-allele and 45 long (L)/L-allele carriers in a randomised double-blind crossover design using functional magnetic resonance imaging and an intertemporal choice task. Results: Overall, we did not find any effect of serotonin and 5-HTTLPR on temporal discounting rates or the brain networks associated with valuation and cognitive control. Conclusion: Our findings indicate that serotonin may not be directly involved in choices including delays on longer timescales such as days, weeks or months. We speculate that serotonin plays a stronger role in dynamic intertemporal choice tasks where the delays are on a timescale of seconds and hence are therefore directly experienced during the experiment.

“I want it now!” Intertemporal Choice Through the Lens of Valence Weighting Bias

2021 ◽  
Vol 39 (2) ◽  
pp. 243-258
Author(s):  
Javier A. Granados Samayoa ◽  
Russell H. Fazio
Keyword(s):  
Individual Differences ◽  
Intertemporal Choice ◽  
Choice Task ◽  
Self Control ◽  
Self Report ◽  
Negative Valence ◽  
Two Factors ◽  
Positive And Negative Valence ◽  
Characteristic Manner ◽  
Report Measure

The current research presents a novel perspective regarding individual differences in intertemporal choice preferences. We postulate that such differences are partly rooted in individuals’ valence weighting proclivities—their characteristic manner of weighting positive and negative valence when constructing an initial evaluation. Importantly, valence weighting bias should predict intertemporal choice most strongly (a) for those who are relatively low in trait self-control and (b) when the magnitude of the available rewards is relatively small, because these two factors are associated with lesser motivation/resources to deliberate extensively about one's decision. More specifically, we propose that those with a more positive weighting bias give greater weight to the clearly positive immediate reward that is under consideration, and under these conditions, the resulting appraisal shapes choice more strongly. Using a performance-based measure of valence weighting tendencies, a hypothetical intertemporal choice task, and a self-report measure of trait self-control, we provide evidence for our hypothesis.

scholarly journals Orbitofrontal cortical activity during repeated free choice

2012 ◽  
Vol 107 (12) ◽  
pp. 3246-3255 ◽  
Author(s):  
Michael Campos ◽  
Kari Koppitch ◽  
Richard A. Andersen ◽  
Shinsuke Shimojo
Keyword(s):  
Orbitofrontal Cortex ◽  
Choice Behavior ◽  
Free Choice ◽  
Selection Process ◽  
Simultaneous Recording ◽  
Choice Task ◽  
Internal Factors ◽  
Frequent Switching ◽  
Individual Choices

Neurons in the orbitofrontal cortex (OFC) have been shown to encode subjective values, suggesting a role in preference-based decision-making, although the precise relation to choice behavior is unclear. In a repeated two-choice task, subjective values of each choice can account for aggregate choice behavior, which is the overall likelihood of choosing one option over the other. Individual choices, however, are impossible to predict with knowledge of relative subjective values alone. In this study we investigated the role of internal factors in choice behavior with a simple but novel free-choice task and simultaneous recording from individual neurons in nonhuman primate OFC. We found that, first, the observed sequences of choice behavior included periods of exceptionally long runs of each of two available options and periods of frequent switching. Neither a satiety-based mechanism nor a random selection process could explain the observed choice behavior. Second, OFC neurons encode important features of the choice behavior. These features include activity selective for exceptionally long runs of a given choice (stay selectivity) as well as activity selective for switches between choices (switch selectivity). These results suggest that OFC neural activity, in addition to encoding subjective values on a long timescale that is sensitive to satiety, also encodes a signal that fluctuates on a shorter timescale and thereby reflects some of the statistically improbable aspects of free-choice behavior.

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