Genetic studies of learning and memory in mouse models.

2003 ◽  
pp. 103-121 ◽  
Author(s):  
Jeanne M. Wehner ◽  
Seth A. Balogh
Keyword(s):  
Learning And Memory ◽  
Mouse Models ◽  
Genetic Studies

scholarly journals Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APPSwe Mouse Models of Tauopathy and Amyloidosis

eNeuro ◽  
2017 ◽  
Vol 4 (4) ◽  
pp. ENEURO.0025-17.2017 ◽  
Author(s):  
Denise Isabelle Briggs ◽  
Erwin Defensor ◽  
Pooneh Memar Ardestani ◽  
Bitna Yi ◽  
Michelle Halpain ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Learning And Memory ◽  
Mouse Models ◽  
Memory Impairment

scholarly journals Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome

2014 ◽  
Vol 17 (12) ◽  
pp. 1736-1743 ◽  
Author(s):  
Yong-Seok Lee ◽  
Dan Ehninger ◽  
Miou Zhou ◽  
Jun-Young Oh ◽  
Minkyung Kang ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Mouse Models ◽  
Noonan Syndrome ◽  
Memory Deficits ◽  
Learning And Memory Deficits

Abstract 662: Assessing the Biological Consistency in Atherosclerosis Susceptibility Genes Between Mouse and Human Genetic Studies

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Moritz von Scheidt ◽  
Yuqi Zhao ◽  
Zeyneb Kurt ◽  
Heribert Schunkert ◽  
Xia Yang ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Mouse Models ◽  
Mouse Genetics ◽  
Molecular Pathways ◽  
Genetic Studies ◽  
Vast Number ◽  
Treatment And Prevention ◽  
Using Data ◽  
Cytokine Interactions ◽  
Lipids And Lipoproteins

Atherosclerosis is a complex and heritable disease with a vast number of interacting genes, networks and molecular pathways. Mouse genetics has been utilized as a powerful tool to study human atherosclerosis and has identified hundreds of candidate genes; recent human genetic studies have also identified hundreds of suggestive genetic loci for atherosclerotic coronary artery disease (CAD). However, commonalities and differences of biological mechanisms in atherosclerosis between humans and mice are poorly examined. In this study, we aim to provide a systematic biological overview comparing mice and humans on pathway level. We first comprehensively reviewed and summarized known mouse genes associated with atherosclerosis based on studies of genetically modified mouse models. This effort revealed 743 mouse atherosclerosis genes from over 9,000 Pubmed publications, retrieved using the terms “atherosclerosis” or “atherogenesis” and “gene” or “qtl” and “mouse” or “mice” and “apoe” or “ldlr”, and followed by manual review and confirmation of the effects on atherosclerosis. Second, we conducted pathway analysis of the mouse atherosclerosis genes using data from Biocarta, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome. We found pathways including cytokine interactions or dependency to the immune system are highly over-represented among the mouse atherosclerosis genes. Many of these pathways (e.g., metabolism of lipids and lipoproteins) converged with those reported for human GWAS loci, but also highlighted several pathways (e.g., GPCR signaling) having a hitherto unknown effect on atherosclerosis in mice. Our results suggest that although there are certain differences in individual candidate genes, mouse models remain a promising approach to identify complex molecular pathways of atherosclerosis, and insights gained from mouse genetics of atherosclerosis could be validated and transferred to CAD in humans. Future network analysis of the mouse and human genes and pathways will provide further elucidation of the shared or distinct gene-gene regulation and interactions between species. This study might provide new starting points for drug development, therapeutic treatment and prevention of atherosclerosis and CAD in humans.

scholarly journals Fto in the hippocampus mediates depression-like behaviors

2021 ◽  
Author(s):  
Shu Liu ◽  
Jianbo Xiu ◽  
Caiyun Zhu ◽  
Chen Li ◽  
Kexin Meng ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Learning And Memory ◽  
Mouse Models ◽  
Epigenetic Regulation ◽  
Critical Role ◽  
Major Depressive ◽  
Rna Methylation ◽  
Antidepressant Effects ◽  
Beta 2

Abstract Dynamic and reversible RNA methylation has emerged as a new layer of epigenetic regulation of behaviors such as learning and memory; however, whether RNA methylation plays a critical role in the pathophysiology of depression is unclear. Here, we report that expression of the fat mass and obesity associated gene (FTO), a primary RNA demethylase, is downregulated in the hippocampi of both major depressive disorder (MDD) patients and mouse models of depression. Suppressing Fto expression in the hippocampus induces depression-like behaviors in mice, while elevating its expression leads to antidepressant effects. Epitranscriptomic profiling of N6-methyladenosine (m6A) RNA methylation in the hippocampi of Fto knockdown (KD), Fto knockout (cKO), and Fto-overexpressing (OE) mice identified adrenoceptor beta 2 (Adrb2) mRNA as a target of Fto. Adrb2 stimulation reverses the depression-like behaviors and spine loss induced by hippocampal Fto deficiency, possibly via the modulation of hippocampal Sirt1 expression by c-Myc. These findings reveal that Fto in the hippocampus mediates depression-like behaviors and highlight the importance of reversible RNA methylation in driving depression.

scholarly journals Assessment of operant learning and memory in mice born through ICSI

2020 ◽  
Vol 35 (9) ◽  
pp. 2058-2071
Author(s):  
Matthew Lewon ◽  
Yue Wang ◽  
Christina Peters ◽  
Matthew Peterson ◽  
Huili Zheng ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Learning And Memory ◽  
Mouse Models ◽  
Discrimination Learning ◽  
Repeated Measures ◽  
Superior Performance ◽  
Operant Learning ◽  
Increased Risk ◽  
Significant Difference ◽  
Males And Females

Abstract STUDY QUESTION Are there differences in operant learning and memory between mice born through ICSI and naturally conceived control (CTL) mice? SUMMARY ANSWER ICSI females exhibited deficits in the acquisition reward learning relative to CTL females, and ICSI males exhibited deficiencies in discrimination learning and memory relative to CTL males. WHAT IS KNOWN ALREADY Some human outcome studies have suggested that ICSI might be associated with an increased risk of certain cognitive disorders, but only one of two behavioral studies with ICSI mouse models have reported differences between ICSI and CTL females. No studies to date have investigated associative learning in ICSI mice. STUDY DESIGN, SIZE, DURATION Groups of 36 ICSI mice (18 male, 18 female) and 37 CTL mice (19 male, 18 female) aged 3–6 months were compared in a series of operant learning procedures that assessed acquisition of a new behavior, discrimination learning and memory. In total, 16 ICSI mice (9 male, 7 female) and 17 CTL mice (10 male, 7 female) received follow-up discrimination learning and memory assessments at 12 months of age (6 months after the end of initial training) to evaluate retention and reacquisition of learned performances. PARTICIPANTS/MATERIALS, SETTING, METHODS Mice received daily operant learning sessions in experimental chambers in which all stimulus events and the recording of responses were automated. Food rewards were delivered for responding under different conditions of reinforcement, which varied by procedure. Subjects received a successive series of sessions of nose poke acquisition training, discrimination training and the delayed-non-matching-to-position memory procedure. Mixed repeated measures ANOVAs in which the between-subjects factor was group (ICSI vs CTL) and the within-subjects factor was repeated exposures to learning procedures (i.e. sessions) were used to analyze data. MAIN RESULTS AND THE ROLE OF CHANCE In comparisons between all mice (i.e. males and females combined), CTL mice exhibited superior performance relative to ICSI in response acquisition (P = 0.03), discrimination (P = 0.001) and memory (P = 0.007). Sex-specific comparisons between the groups yielded evidence of sexual dimorphism. ICSI females exhibited a deficit in acquisition learning relative to CTL females (P < 0.001), but there was not a significant difference between CTL and ICSI males. In the discrimination and memory tasks, ICSI males exhibited deficits relative to CTL males (P = 0.002 and P = 0.02, respectively) but the differences between females in these tasks were not significant. There was no difference in discrimination or memory retention/re-acquisition assessments conducted with mice at 12 months of age. ICSI males and females weighed significantly more than CTL counterparts at all points during the experiment. LARGE SCALE DATA N/A LIMITATIONS, REASONS FOR CAUTION The study was not blinded. All learning assessments utilized food reward; other assessments of operant, Pavlovian and nonassociative learning are needed to fully characterize learning in ICSI mice and speculate regarding the implications for cognitive function in humans conceived via ICSI. WIDER IMPLICATIONS OF THE FINDINGS Studying learning and memory processes in mouse models have the potential to shed light on ICSI outcomes at the level of cognitive function. Future research should use multiple learning paradigms, assess both males and females, and investigate the effects of variables related to the ICSI procedure. Studying cognitive function in ICSI is an interdisciplinary endeavor and requires co-ordination between researchers at the genetic and psychological levels of analysis. STUDY FUNDING/COMPETING INTEREST(S) This work was supported, in part, by grants from the NIH (P30GM110767, HD071736 and HD085506 to W.Y.), the Templeton Foundation (61174 to W.Y.) and a New Scholarly Endeavor Grant from the University of Nevada, Reno Office of Research and Innovation (to M.L., Y.W., H.Z., L.H. and W.Y.). The authors declare no competing interests.

Peripheral Administration of GSK-3β Antisense Oligonucleotide Improves Learning and Memory in SAMP8 and Tg2576 Mouse Models of Alzheimer’s Disease

2016 ◽  
Vol 54 (4) ◽  
pp. 1339-1348 ◽  
Author(s):  
Susan A. Farr ◽  
Karin E. Sandoval ◽  
Michael L. Niehoff ◽  
Ken A. Witt ◽  
Vijaya B. Kumar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Learning And Memory ◽  
Mouse Models ◽  
Antisense Oligonucleotide ◽  
Tg2576 Mouse ◽  
Gsk 3Β

P4-338: Hilar transplantation of MGE-derived inhibitory interneuron progenitors restores normal learning and memory in Alzheimer's disease mouse models

2013 ◽  
Vol 9 ◽  
pp. P856-P856
Author(s):  
Leslie Tong ◽  
Biljana Djukic ◽  
Christine Arnold ◽  
Seo Yeon Yoon ◽  
John Rubenstein ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Learning And Memory ◽  
Mouse Models ◽  
Inhibitory Interneuron
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