scholarly journals The Resazurin-Resorufin System: Insights From a Decade of “Smart” Tracer Development for Hydrologic Applications

2018 ◽  
Vol 54 (9) ◽  
pp. 6877-6889 ◽  
Author(s):  
Julia L. A. Knapp ◽  
Ricardo González-Pinzón ◽  
Roy Haggerty
Keyword(s):  
Tracer Development

Tracer Development for Magnetic Particle Imaging

2012 ◽  
pp. 123-127 ◽  
Author(s):  
Harald Kratz ◽  
Dietmar Eberbeck ◽  
Susanne Wagner ◽  
Jörg Schnorr ◽  
Matthias Taupitz
Keyword(s):  
Magnetic Particle ◽  
Magnetic Particle Imaging ◽  
Particle Imaging ◽  
Tracer Development

scholarly journals Bridging the gaps in 18F PET tracer development

2016 ◽  
Vol 9 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Michael G. Campbell ◽  
Joel Mercier ◽  
Christophe Genicot ◽  
Véronique Gouverneur ◽  
Jacob M. Hooker ◽  
...  
Keyword(s):  
Pet Tracer ◽  
Tracer Development

Efficient Synthesis of11C-Acrylesters,11C-Acrylamides and Their Application in Michael Addition Reactions for PET Tracer Development

2017 ◽  
Vol 2017 (34) ◽  
pp. 5154-5162 ◽  
Author(s):  
Ulrike Filp ◽  
Anna L. Pees ◽  
Carlotta Taddei ◽  
Aleksandra Pekošak ◽  
Antony D. Gee ◽  
...  
Keyword(s):  
Michael Addition ◽  
Addition Reactions ◽  
Efficient Synthesis ◽  
Pet Tracer ◽  
Tracer Development

BIOMARKERS IN PSYCHOTROPIC DRUG DEVELOPMENT: Integration of Data across Multiple Domains

2005 ◽  
Vol 45 (1) ◽  
pp. 227-246 ◽  
Author(s):  
Peter R. Bieck ◽  
William Z. Potter
Keyword(s):  
Drug Development ◽  
Psychotropic Drug ◽  
Current Status ◽  
Imaging Studies ◽  
Investigational Drugs ◽  
Early Imaging ◽  
Multiple Domains ◽  
The Brain ◽  
Proteomic Research ◽  
Tracer Development

This review focuses on the current status of biomarkers and/or approaches critical to assessing novel neuroscience targets with an emphasis on new paradigms and challenges in this field of research. The importance of biomarker data integration for psychotropic drug development is illustrated with examples for clinically used medications and investigational drugs. The question remains how to verify access to the brain. Early imaging studies including micro-PET can help to overcome this. However, in case of delayed tracer development or because of no feasible application of brain imaging effects of the molecule, using CSF as a matrix could fill this gap. Proteomic research using CSF will hopefully have a major impact on the development of treatments for psychiatric disorders.

scholarly journals Update on PET Tracer Development for Muscarinic Acetylcholine Receptors

2021 ◽  
Vol 14 (6) ◽  
pp. 530
Author(s):  
Marius Ozenil ◽  
Jonas Aronow ◽  
Marlon Millard ◽  
Thierry Langer ◽  
Wolfgang Wadsak ◽  
...  
Keyword(s):  
Nervous System ◽  
Acetylcholine Receptors ◽  
Muscarinic Acetylcholine Receptors ◽  
Muscarinic Acetylcholine ◽  
Pet Tracer ◽  
Positron Emission ◽  
Muscarinic Cholinergic ◽  
Imaging Properties ◽  
Tracer Development

The muscarinic cholinergic system regulates peripheral and central nervous system functions, and, thus, their potential as a therapeutic target for several neurodegenerative diseases is undoubted. A clinically applicable positron emission tomography (PET) tracer would facilitate the monitoring of disease progression, elucidate the role of muscarinic acetylcholine receptors (mAChR) in disease development and would aid to clarify the diverse natural functions of mAChR regulation throughout the nervous system, which still are largely unresolved. Still, no mAChR PET tracer has yet found broad clinical application, which demands mAChR tracers with improved imaging properties. This paper reviews strategies of mAChR PET tracer design and summarizes the binding properties and preclinical evaluation of recent mAChR tracer candidates. Furthermore, this work identifies the current major challenges in mAChR PET tracer development and provides a perspective on future developments in this area of research.

scholarly journals 2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development

RSC Advances ◽  
2014 ◽  
Vol 4 (73) ◽  
pp. 38726-38742 ◽  
Author(s):  
Markus Laube ◽  
Christoph Tondera ◽  
Sai Kiran Sharma ◽  
Nicole Bechmann ◽  
Franz-Jacob Pietzsch ◽  
...  
Keyword(s):  
Methoxy Group ◽  
Fischer Indole Synthesis ◽  
Cox 2 ◽  
Cox 2 Inhibitors ◽  
Indole Synthesis ◽  
Tracer Development

A series of 2,3-diaryl-substituted indoles containing a fluorine or methoxy group was synthesized via Fischer indole synthesis, McMurry cyclization, or Bischler–Möhlau reaction to identify potential leads for PET radiotracer development.

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