NMR Solution Structures of Stereoisomeric Covalent Polycyclic Aromatic Carcinogen−DNA Adducts:  Principles, Patterns, and Diversity

1997 ◽  
Vol 10 (2) ◽  
pp. 111-146 ◽  
Author(s):  
Nicholas E. Geacintov ◽  
Monique Cosman ◽  
Brian E. Hingerty ◽  
Shantu Amin ◽  
Suse Broyde ◽  
...  
Keyword(s):  
Dna Adducts ◽  
Solution Structures ◽  
Polycyclic Aromatic ◽  
Nmr Solution Structures

scholarly journals NMR Solution Structures of Adducts Derived from the Binding of Polycyclic Aromatic Diol Epoxides to DNA

1996 ◽  
Vol 10 (1-4) ◽  
pp. 153-160
Author(s):  
M. Cosman ◽  
B. E. Hingerty ◽  
S. Amin ◽  
S. Broyde ◽  
N. E. Geacintov ◽  
...  
Keyword(s):  
Solution Structures ◽  
Diol Epoxides ◽  
Aromatic Diol ◽  
Polycyclic Aromatic ◽  
Nmr Solution Structures

Comparison of the NMR solution structures of cyclosporin A determined by different techniques

1991 ◽  
Vol 92 (3) ◽  
pp. 468-479 ◽  
Author(s):  
Ruth Pachter ◽  
Russ B Altman ◽  
Jerzy Czaplicki ◽  
Oleg Jardetzky
Keyword(s):  
Cyclosporin A ◽  
Solution Structures ◽  
Nmr Solution Structures

scholarly journals NMR Solution Structures of Bistranded Abasic Site Lesions in DNA†‡

Biochemistry ◽  
2008 ◽  
Vol 47 (46) ◽  
pp. 11909-11919 ◽  
Author(s):  
Raphael D. Hazel ◽  
Kegui Tian ◽  
Carlos de los Santos
Keyword(s):  
Abasic Site ◽  
Solution Structures ◽  
Nmr Solution Structures

DNA Adducts Formed bysynDihydrodiol Epoxides of Polycyclic Aromatic Hydrocarbons

1994 ◽  
Vol 6 (1-4) ◽  
pp. 87-93 ◽  
Author(s):  
Jan Szeliga ◽  
Bruce D. Hilton ◽  
Hongmee Lee ◽  
Ronald G. Harvey ◽  
Anthony Dipple
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Polycyclic Aromatic

scholarly journals Intestinal polycyclic aromatic hydrocarbon-DNA adducts in a population of beluga whales with high levels of gastrointestinal cancers

2018 ◽  
Vol 60 (1) ◽  
pp. 29-41 ◽  
Author(s):  
Miriam C. Poirier ◽  
Stéphane Lair ◽  
Robert Michaud ◽  
Elena E. Hernández-Ramon ◽  
Kathyayini V. Divi ◽  
...  
Keyword(s):  
Polycyclic Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbon ◽  
Dna Adducts ◽  
Gastrointestinal Cancers ◽  
Beluga Whales ◽  
Polycyclic Aromatic

scholarly journals Association of polycyclic aromatic hydrocarbons in moss with blood biomarker among nearby residents in Portland, Oregon

2021 ◽  
Author(s):  
Igor Burstyn ◽  
Geoffrey H. Donovan ◽  
Yvonne L. Michael ◽  
Sarah Jovan
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Air Quality ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Human Health Risk ◽  
Monitoring Methods ◽  
Wood Fire ◽  
Individual Determinants ◽  
Polycyclic Aromatic ◽  
Environmental Air

Polycyclic aromatic hydrocarbons (PAHs) are a component of air pollutants that are costly to measure using traditional air-quality monitoring methods. We used an epiphytic bio-indicator (moss genus: Orthotrichum) to cost-effectively evaluate atmospheric deposition of PAHs in Portland, Oregon in May 2013. However, it is unclear if measurements derived from these bioindicators are good proxies for human exposure. To address this question, we simultaneously, measured PAH-DNA adducts in blood samples of non-smokers residing close to the sites of moss measurements. We accounted for individual determinants of PAH uptake that are not related to environmental air quality through questionnaires, e.g., wood fires, consumption of barbecued and fried meats. Correlation and linear regression (to control for confounders from the lifestyle factors) evaluated the associations. We did not observe evidence of an association between PAH levels in moss and PAH-DNA adducts in blood of nearby residents, but higher level of adduct were evident in those who used wood fire in their houses in the last 48 hours. It remains to be determined whether bio-indicators in moss can be used for human health risk assessment.

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