scholarly journals Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer risk

2008 ◽  
Vol 44 (5) ◽  
pp. 710-717 ◽  
Author(s):  
Jing Shen ◽  
Marilie D. Gammon ◽  
Mary Beth Terry ◽  
Susan L. Teitelbaum ◽  
Sybil M. Eng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Xeroderma Pigmentosum ◽  
Complementation Group ◽  
Polycyclic Aromatic

scholarly journals Polycyclic Aromatic Hydrocarbons and Breast Cancer: A Review of the Literature

Breast Care ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. 316-318 ◽  
Author(s):  
Jessica Korsh ◽  
Allison Shen ◽  
Kristen Aliano ◽  
Thomas Davenport
Keyword(s):  
Breast Cancer ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Fossil Fuels ◽  
Exposure Dose ◽  
The Body ◽  
Case Control Studies ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons (PAHs) exist and persist in the atmosphere due to the incomplete combustion of fossil fuels, and are established human carcinogens. The influence of PAHs on the development of breast cancer, the most commonly diagnosed cancer in women worldwide, remains unclear. As established risk factors only account for approximately 41% of the breast cancer cases in the USA, researchers have sought to uncover environmental factors involved in breast cancer development. The breasts are particularly susceptible to aromatic carcinogenesis, and the implementation of biomarkers has provided promising insights regarding PAH-DNA adducts in breast cancer. The use of biomarkers measuring PAH-DNA adducts assesses exposure to eliminate the bias inherent in self-reporting measures in case-control studies investigating the link between PAHs and cancer. Adduct levels reflect exposure dose as well as how the body responds to this exposure, which is partially attributable to genetic variability. Evidence suggests that exposure to PAHs has a causational effect on breast cancer in humans, yet this interaction is not clearly understood. In vitro and animal-based studies have consistently revealed that exposure to PAHs deleteriously affects breast tissue, but there is no definitive link between these compounds and breast cancer.

scholarly journals DNA adducts as a measure of lung cancer risk in humans exposed to polycyclic aromatic hydrocarbons.

1993 ◽  
Vol 99 ◽  
pp. 71-75 ◽  
Author(s):  
E Kriek ◽  
F J Van Schooten ◽  
M J Hillebrand ◽  
F E Van Leeuwen ◽  
L Den Engelse ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Cancer Risk ◽  
Dna Adducts ◽  
Aromatic Hydrocarbons ◽  
Lung Cancer Risk ◽  
Polycyclic Aromatic

scholarly journals Association of xeroderma pigmentosum complementation group G Asp1104His polymorphism with breast cancer risk: A cumulative meta-analysis

2014 ◽  
Vol 2 (6) ◽  
pp. 1177-1181 ◽  
Author(s):  
XIAO-MING XU ◽  
LONG-CHUAN XIE ◽  
LING-LING YUAN ◽  
XIAO-LI HU ◽  
JIAN-QIANG JIN ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Xeroderma Pigmentosum ◽  
Meta Analysis ◽  
Complementation Group

scholarly journals Classroom Dust-Bound Polycyclic Aromatic Hydrocarbons in Jeddah Primary Schools, Saudi Arabia: Level, Characteristics and Health Risk Assessment

2020 ◽  
Vol 17 (8) ◽  
pp. 2779
Author(s):  
Mansour A. Alghamdi ◽  
Salwa K. Hassan ◽  
Noura A. Alzahrani ◽  
Marwan Y. Al Sharif ◽  
Mamdouh I. Khoder
Keyword(s):  
Polycyclic Aromatic Hydrocarbons ◽  
Cancer Risk ◽  
Urban Schools ◽  
Health Risks ◽  
Aromatic Hydrocarbons ◽  
Primary Schools ◽  
Residential Schools ◽  
Suburban Schools ◽  
Lifetime Cancer Risk ◽  
Polycyclic Aromatic

Data concerning polycyclic aromatic hydrocarbons (PAHs) in Jeddah’s schools, Saudi Arabia, and their implications for health risks to children, is scarce. Classroom air conditioner filter dusts were collected from primary schools in urban, suburban and residential areas of Jeddah. This study aimed to assess the characteristics of classroom-dust-bound PAHs and the health risks to children of PAH exposure. Average PAH concentrations were higher in urban schools than suburban and residential schools. Benzo (b)fluoranthene (BbF), benzo(ghi)perylene (BGP), chrysene (CRY) and Dibenz[a,h]anthracene (DBA) at urban and suburban schools and BbF, BGP, fluoranthene (FLT) and indeno (1, 2, 3, −cd)pyrene (IND) at residential schools were the dominant compounds in classroom dust. PAHs with five aromatic rings were the most abundant at all schools. The relative contribution of the individual PAH compounds to total PAH concentrations in the classroom dusts of schools indicate that the study areas do share a common source, vehicle emissions. Based on diagnostic ratios of PAHs, they are emitted from local pyrogenic sources, and traffic is the significant PAH source, with more significant contributions from gasoline-fueled than from diesel cars. Based on benzo[a]pyrene equivalent (BaPequi) calculations, total carcinogenic activity (TCA) for total PAHs represent 21.59% (urban schools), 20.99% (suburban schools), and 18.88% (residential schools) of total PAH concentrations. DBA and BaP were the most dominant compounds contributing to the TCA, suggesting the importance of BaP and DBA as surrogate compounds for PAHs in this schools. Based on incremental lifetime cancer risk (ILCingestion, ILCRinhalation, ILCRdermal) and total lifetime cancer risk (TLCR)) calculations, the order of cancer risk was: urban schools > suburban schools > residential schools. Both ingestion and dermal contact are major contributors to cancer risk. Among PAHs, DBA, BaP, BbF, benzo(a)anthracene (BaA), benzo(k)fluoranthene (BkF), and IND have the highest ILCR values at all schools. LCR and TLCR values at all schools were lower than 10−6, indicating virtual safety. DBA, BaP and BbF were the predominant contributors to cancer effects in all schools.

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