Synthesis and Monoamine Oxidase B Catalyzed Oxidation of C-4 Heteroaromatic Substituted 1,2,3,6-Tetrahydropyridine Derivatives

Sandeep K. Nimkar; Andrea H. Anderson; John M. Rimoldi; Matthew Stanton; Kay P. Castagnoli; Stéphane Mabic; Y.-X. Wang; Neal Castagnoli

doi:10.1021/tx960063o

Synthesis and Monoamine Oxidase B Catalyzed Oxidation of C-4 Heteroaromatic Substituted 1,2,3,6-Tetrahydropyridine Derivatives

Chemical Research in Toxicology ◽

10.1021/tx960063o ◽

1996 ◽

Vol 9 (6) ◽

pp. 1013-1022 ◽

Cited By ~ 22

Author(s):

Sandeep K. Nimkar ◽

Andrea H. Anderson ◽

John M. Rimoldi ◽

Matthew Stanton ◽

Kay P. Castagnoli ◽

...

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Catalyzed Oxidation

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Nitrogen Kinetic Isotope Effects for the Monoamine Oxidase B-Catalyzed Oxidation of Benzylamine and (1,1-2H2)Benzylamine: Nitrogen Rehybridization and CH Bond Cleavage Are Not Concerted

Journal of the American Chemical Society ◽

10.1021/ja205629b ◽

2011 ◽

Vol 133 (32) ◽

pp. 12319-12321 ◽

Cited By ~ 37

Author(s):

Susanna MacMillar ◽

Dale E. Edmondson ◽

Olle Matsson

Keyword(s):

Monoamine Oxidase ◽

Bond Cleavage ◽

Isotope Effects ◽

Kinetic Isotope Effects ◽

Monoamine Oxidase B ◽

Kinetic Isotope ◽

Catalyzed Oxidation

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Monoamine Oxidase B-Catalyzed Oxidation of Cinnamylamine 2,3-Oxide. Further Evidence against a Nucleophilic Mechanism

Journal of the American Chemical Society ◽

10.1021/ja00104a058 ◽

1994 ◽

Vol 116 (25) ◽

pp. 11590-11591 ◽

Cited By ~ 12

Author(s):

Richard B. Silverman ◽

Xingliang Lu ◽

Joseph J. P. Zhou ◽

Aaron Swihart

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Nucleophilic Mechanism ◽

Catalyzed Oxidation

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Mechanistic Studies on the Monoamine Oxidase B Catalyzed Oxidation of 1,4-Disubstituted Tetrahydropyridines

Chemical Research in Toxicology ◽

10.1021/tx00042a005 ◽

1994 ◽

Vol 7 (6) ◽

pp. 740-744 ◽

Cited By ~ 13

Author(s):

Simon Kuttab ◽

Amit Kalgutkar ◽

Neal Castagnoli

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Mechanistic Studies ◽

Catalyzed Oxidation

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The Neuronal Nitric Oxide Synthase Inhibitor 7-Nitroindazole Also Inhibits the Monoamine Oxidase-B-Catalyzed Oxidation of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Chemical Research in Toxicology ◽

10.1021/tx970001d ◽

1997 ◽

Vol 10 (4) ◽

pp. 364-368 ◽

Cited By ~ 71

Author(s):

Kay Castagnoli ◽

Sonya Palmer ◽

Andrea Anderson ◽

Tjerk Bueters ◽

Neal Castagnoli

Keyword(s):

Nitric Oxide ◽

Nitric Oxide Synthase ◽

Monoamine Oxidase ◽

Neuronal Nitric Oxide Synthase ◽

Monoamine Oxidase B ◽

Nitric Oxide Synthase Inhibitor ◽

Synthase Inhibitor ◽

Oxide Synthase ◽

Catalyzed Oxidation

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Assessment of Structural Requirements for the Monoamine Oxidase-B-Catalyzed Oxidation of 1,4-Disubstituted-1,2,3,6-tetrahydropyridine Derivatives Related to the Neurotoxin 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Journal of Medicinal Chemistry ◽

10.1021/jm9603882 ◽

1996 ◽

Vol 39 (19) ◽

pp. 3694-3700 ◽

Cited By ~ 12

Author(s):

Stéphane Mabic ◽

Neal Castagnoli

Keyword(s):

Monoamine Oxidase ◽

Monoamine Oxidase B ◽

Structural Requirements ◽

Catalyzed Oxidation

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Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-cyclopropyl-1,2,3,6-tetrahydropyridines

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(97)10033-5 ◽

1998 ◽

Vol 6 (3) ◽

pp. 283-291 ◽

Cited By ~ 11

Author(s):

Christelle Franot ◽

Stéphane Mabic ◽

Neal Castagnol Jr

Keyword(s):

Monoamine Oxidase ◽

Chemical Model ◽

Monoamine Oxidase B ◽

Model Studies ◽

Substituted 1 ◽

Catalyzed Oxidation

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Chemical model studies on the monoamine oxidase-B catalyzed oxidation of 4-substituted 1-methyl-1,2,3,6-tetrahydropyridines

Bioorganic & Medicinal Chemistry ◽

10.1016/s0968-0896(97)00101-6 ◽

1997 ◽

Vol 5 (8) ◽

pp. 1519-1529 ◽

Cited By ~ 4

Author(s):

Christelle Franot ◽

Stéphane Mabic ◽

Neal Castagnoli

Keyword(s):

Monoamine Oxidase ◽

Chemical Model ◽

Monoamine Oxidase B ◽

Model Studies ◽

Substituted 1 ◽

Catalyzed Oxidation

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Faculty Opinions recommendation of Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726556895.25654 ◽

2001 ◽

Author(s):

Vincent Rotello

Keyword(s):

Monoamine Oxidase ◽

Neurological Disorders ◽

Drug Target ◽

Monoamine Oxidase B

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Faculty Opinions recommendation of Monoamine oxidase B inhibitor, selegiline, reduces 18F-THK5351 uptake in the human brain.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727469372.793537455 ◽

2017 ◽

Author(s):

Daniela Perani

Keyword(s):

Monoamine Oxidase ◽

Human Brain ◽

Monoamine Oxidase B

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Ligand-Based Virtual Screening Using Tailored Ensembles: A Prioritization Tool for Dual A2A Adenosine Receptor Antagonists / Monoamine Oxidase B Inhibitors

Current Pharmaceutical Design ◽

10.2174/1381612822666160302103542 ◽

2016 ◽

Vol 22 (21) ◽

pp. 3082-3096 ◽

Cited By ~ 7

Author(s):

Aliuska Morales Helguera ◽

Yunierkis Perez-Castillo ◽

M. Natália D.S. Cordeiro ◽

Eduardo Tejera ◽

César Paz-y-Miño ◽

...

Keyword(s):

Virtual Screening ◽

Monoamine Oxidase ◽

Adenosine Receptor ◽

Monoamine Oxidase B ◽

Receptor Antagonists ◽

A2a Adenosine Receptor

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