3-Aminobenzanthrone, a Human Metabolite of the Environmental Pollutant 3-Nitrobenzanthrone, Forms DNA Adducts after Metabolic Activation by Human and Rat Liver Microsomes:  Evidence for Activation by Cytochrome P450 1A1 and P450 1A2

2004 ◽  
Vol 17 (8) ◽  
pp. 1092-1101 ◽  
Author(s):  
Volker M. Arlt ◽  
Alan Hewer ◽  
Bernd L. Sorg ◽  
Heinz H. Schmeiser ◽  
David H. Phillips ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Rat Liver ◽  
Dna Adducts ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Environmental Pollutant ◽  
Rat Liver Microsomes ◽  
Cytochrome P450 1A1 ◽  
Human Metabolite

Estrogenic activity of an environmental pollutant, 2-nitrofluorene, after metabolic activation by rat liver microsomes

2003 ◽  
Vol 303 (2) ◽  
pp. 419-426 ◽  
Author(s):  
Takashi Fujimoto ◽  
Shigeyuki Kitamura ◽  
Seigo Sanoh ◽  
Kazumi Sugihara ◽  
Shin’ichi Yoshihara ◽  
...  
Keyword(s):  
Rat Liver ◽  
Estrogenic Activity ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Environmental Pollutant ◽  
Rat Liver Microsomes

scholarly journals Involvement of cytochrome P450 2E1 in the (ω–1)-hydroxylation of oleic acid in human and rat liver microsomes

1998 ◽  
Vol 39 (6) ◽  
pp. 1210-1219 ◽  
Author(s):  
Fadi Adas ◽  
François Berthou ◽  
Daniel Picart ◽  
Patrick Lozac'h ◽  
Françoise Beaugé ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Oleic Acid ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Cytochrome P450 2E1

Rat liver microsomal metabolism of o-aminophenol and N-(2-methoxyphenyl)hydroxylamine, two metabolites of the environmental pollutant and carcinogen o-anisidine in humans

2010 ◽  
Vol 75 (12) ◽  
pp. 1229-1247 ◽  
Author(s):  
Karel Naiman ◽  
Petr Hodek ◽  
Jiří Liberda ◽  
Heinz H. Schmeiser ◽  
Eva Frei ◽  
...  
Keyword(s):  
Rat Liver ◽  
Dna Adducts ◽  
Cytochromes P450 ◽  
Environmental Pollutant ◽  
Microsomal Metabolism ◽  
Human Metabolite ◽  
Hepatic Microsomes

o-Aminophenol and N-(2-methoxyphenyl)hydroxylamine are human metabolites of the industrial and environmental pollutant and bladder carcinogen 2-methoxyaniline (o-anisidine). The latter one is also a human metabolite of another pollutant and bladder carcinogen, 2-methoxynitrobenzene (o-nitroanisole). Here, we investigated the ability of rat hepatic micro- somes to metabolize these metabolites. N-(2-methoxyphenyl)hydroxylamine is metabolized by rat hepatic microsomes to o-aminophenol and predominantly o-anisidine, the parent carcinogen from which N-(2-methoxyphenyl)hydroxylamine is formed. In addition, two N-(2-methoxyphenyl)hydroxylamine metabolites, whose exact structures have not been identified as yet, were generated. On the contrary, no metabolites were found to be formed from o-aminophenol by rat hepatic microsomes. Whereas N-(2-methoxyphenyl)hydroxylamine is responsible for formation of three deoxyguanosine adducts in DNA, o-aminophenol seems to be a detoxication metabolite of N-(2-methoxyphenyl)hydroxylamine and/or a parental carcinogen, o-anisidine; no o-aminophenol-derived DNA adducts were found after its reaction with microsomal cytochromes P450 and peroxidases.

Metabolic activation of hydralazine by rat liver microsomes

1987 ◽  
Vol 36 (16) ◽  
pp. 2667-2672 ◽  
Author(s):  
Lynn B. LaCagnin ◽  
Howard D. Colby ◽  
Naresh S. Dalal ◽  
John P. O'Donnell
Keyword(s):  
Rat Liver ◽  
Liver Microsomes ◽  
Metabolic Activation ◽  
Rat Liver Microsomes
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