Metabolic Response of Normal and Malignant Tissue to Acute and Chronic Methionine Stress in Athymic Mice Bearing Human Glial Tumor Xenografts

2002 ◽  
Vol 15 (11) ◽  
pp. 1472-1479 ◽  
Author(s):  
Demetrius M. Kokkinakis ◽  
Jacquellyn B. Wick ◽  
Qing Xian Zhou
Keyword(s):  
Metabolic Response ◽  
Athymic Mice ◽  
Malignant Tissue ◽  
Glial Tumor ◽  
Tumor Xenografts ◽  
Methionine Stress

Recombinant interleukin-2 inhibits growth of human tumor xenografts in congenitally athymic mice

1987 ◽  
Vol 14 (4) ◽  
pp. 325-330 ◽  
Author(s):  
J BUBENIK ◽  
J KIELER ◽  
V TROMHOLT ◽  
M INDROVA ◽  
E LOTZOVA
Keyword(s):  
Interleukin 2 ◽  
Human Tumor ◽  
Athymic Mice ◽  
Human Tumor Xenografts ◽  
Tumor Xenografts ◽  
Recombinant Interleukin 2

Effect of long‐term depletion of plasma methionine on the growth and survival of human brain tumor xenografts in athymic mice

1997 ◽  
Vol 29 (3) ◽  
pp. 195-204 ◽  
Author(s):  
Demetrius M. Kokkinakis ◽  
S. Clifford Schold ◽  
Hiroki Hori ◽  
Tsutomu Nobori
Keyword(s):  
Brain Tumor ◽  
Human Brain ◽  
Athymic Mice ◽  
Human Brain Tumor ◽  
Growth And Survival ◽  
Tumor Xenografts

scholarly journals Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice

2007 ◽  
Vol 9 (3) ◽  
pp. 240-244 ◽  
Author(s):  
Michael A. Badruddoja ◽  
Stephen T. Keir ◽  
Ivan King ◽  
Joseph Zeidner ◽  
James J. Vredenburgh ◽  
...  
Keyword(s):  
Athymic Mice ◽  
Cns Tumor ◽  
Tumor Xenografts

scholarly journals A comparison of 111In- or 64Cu-DOTA-trastuzumab Fab fragments for imaging subcutaneous HER2-positive tumor xenografts in athymic mice using microSPECT/CT or microPET/CT

2011 ◽  
Vol 1 (1) ◽  
pp. 15 ◽  
Author(s):  
Conrad Chan ◽  
Deborah A Scollard ◽  
Kristin McLarty ◽  
Serena Smith ◽  
Raymond M Reilly
Keyword(s):  
Athymic Mice ◽  
Her2 Positive ◽  
Tumor Xenografts ◽  
Fab Fragments

scholarly journals Near-Infrared Fluorescence Imaging of Carbonic Anhydrase IX in Athymic Mice Bearing HT-29 Tumor Xenografts

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Jianbo Li ◽  
Baoliang Bao ◽  
Lei Liu ◽  
Xuemei Wang
Keyword(s):  
Near Infrared ◽  
Imaging Modality ◽  
Receptor Expression ◽  
Athymic Mice ◽  
Binding Studies ◽  
Preclinical Research ◽  
Near Infrared Fluorescence ◽  
Tumor Xenografts ◽  
Nirf Imaging ◽  
Ht 29

Near-infrared fluorescence (NIRF) imaging technology is a highly sensitive imaging modality and has been widely used in noninvasively studying the status of receptor expression in small animal models, with an appropriate NIRF probe targeting a specific receptor. In this report, Cy5.5-conjugated anti-CAIX monoclonal antibody (Mab-Cy5.5) was evaluated in athymic mice bearing HT-29 tumor xenografts in order to investigate the effect of conjugate on tumor targeting efficacy. In vitro binding studies showed that Mab-Cy5.5 could specifically bind to the cells which expressed CAIX. Results from in vivo imaging showed that HT-29 tumor xenografts can be clearly visualized at 48 h after injection of Mab-Cy5.5, and in the blocking experiment, free anti-CAIX antibody effectively blocked the concentration of Mab-Cy5.5 in the tumors. Western blotting and immunohistochemistry analysis of HT-29 tumor xenografts verified the expression of CAIX in HT-29 tumors. Mab-Cy5.5 could specifically bind to the tumors which expressed CAIX. These results suggested that Mab-Cy5.5 was suitable for CAIX expression imaging in the preclinical research.

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