Chemical and Glutathione Conjugation-Related Degradation of Fotemustine: Formation and Characterization of a Glutathione Conjugate of Diethyl (1-Isocyanatoethyl)phosphonate, a Reactive Metabolite of Fotemustine

J. P. G. Brakenhoff; J. N. M. Commandeur; F. J. J. de Kanter; B. L. M. van Baar; W. C. M. M. Luijten; N. P. E. Vermeulen

doi:10.1021/tx00039a016

Chemical and Glutathione Conjugation-Related Degradation of Fotemustine: Formation and Characterization of a Glutathione Conjugate of Diethyl (1-Isocyanatoethyl)phosphonate, a Reactive Metabolite of Fotemustine

Chemical Research in Toxicology ◽

10.1021/tx00039a016 ◽

1994 ◽

Vol 7 (3) ◽

pp. 380-389 ◽

Cited By ~ 4

Author(s):

J. P. G. Brakenhoff ◽

J. N. M. Commandeur ◽

F. J. J. de Kanter ◽

B. L. M. van Baar ◽

W. C. M. M. Luijten ◽

...

Keyword(s):

Reactive Metabolite ◽

Glutathione Conjugate ◽

Glutathione Conjugation

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Characterization of Mechanisms of Glutathione Conjugation with Halobenzoquinones in Solution and HepG2 Cells

Environmental Science & Technology ◽

10.1021/acs.est.7b05945 ◽

2018 ◽

Vol 52 (5) ◽

pp. 2898-2908 ◽

Cited By ~ 7

Author(s):

Wei Wang ◽

Yichao Qian ◽

Jinhua Li ◽

Naif Aljuhani ◽

Arno G. Siraki ◽

...

Keyword(s):

Hepg2 Cells ◽

Glutathione Conjugation

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Characterization of the CYP and UGT enzymes involved in reactive metabolite generation from bromfenac and bromfenac indolinone

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2018.09.214 ◽

2019 ◽

Vol 34 (1) ◽

pp. S62

Author(s):

Aprajita Yadav ◽

Timothy Carlson ◽

James P. Driscoll

Keyword(s):

Reactive Metabolite ◽

Metabolite Generation

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Inactivation of Glyceraldehyde-3-phosphate Dehydrogenase by a Reactive Metabolite of Acetaminophen and Mass Spectral Characterization of an Arylated Active Site Peptide

Chemical Research in Toxicology ◽

10.1021/tx970090u ◽

1997 ◽

Vol 10 (10) ◽

pp. 1097-1103 ◽

Cited By ~ 41

Author(s):

Eric C. Dietze ◽

Andrea Schäfer ◽

James G. Omichinski ◽

Sidney D. Nelson

Keyword(s):

Active Site ◽

Spectral Characterization ◽

Reactive Metabolite ◽

Mass Spectral

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Characterization of glutathione conjugation in humans: Stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)- and (S)-2-bromoisovalerylurea in healthy volunteers

Clinical Pharmacology & Therapeutics ◽

10.1038/clpt.1993.8 ◽

1993 ◽

Vol 53 (1) ◽

pp. 49-58 ◽

Cited By ~ 6

Author(s):

Titia M T Mulders ◽

Vicki Venizelos ◽

Rik Schoemaker ◽

Adam F Cohen ◽

Douwe D Breimer ◽

...

Keyword(s):

Urinary Excretion ◽

Healthy Volunteers ◽

Glutathione Conjugation

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Alkylation of protein disulfide isomerase by the episulfonium ion derived from the glutathione conjugate of 1,2-dichloroethane and mass spectrometric characterization of the adducts

Archives of Biochemistry and Biophysics ◽

10.1016/j.abb.2003.10.016 ◽

2004 ◽

Vol 423 (1) ◽

pp. 136-147 ◽

Cited By ~ 11

Author(s):

Rhonda S. Kaetzel ◽

Martha D. Stapels ◽

Douglas F. Barofsky ◽

Donald J. Reed

Keyword(s):

Protein Disulfide Isomerase ◽

Mass Spectrometric ◽

Glutathione Conjugate ◽

Disulfide Isomerase ◽

Protein Disulfide ◽

Episulfonium Ion

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Characterization of the chemical reactivity and nephrotoxicity of N-acetyl-S-(1,2-dichlorovinyl)-l-cysteine sulfoxide, a potential reactive metabolite of trichloroethylene

Toxicology and Applied Pharmacology ◽

10.1016/j.taap.2012.12.002 ◽

2013 ◽

Vol 267 (1) ◽

pp. 1-10 ◽

Cited By ~ 9

Author(s):

Roy M. Irving ◽

Marie E. Pinkerton ◽

Adnan A. Elfarra

Keyword(s):

Chemical Reactivity ◽

Reactive Metabolite ◽

Cysteine Sulfoxide

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Detection and Characterization of a Glutathione Conjugate of Ochratoxin A

Chemical Research in Toxicology ◽

10.1021/tx0255929 ◽

2002 ◽

Vol 15 (12) ◽

pp. 1581-1588 ◽

Cited By ~ 47

Author(s):

Jian Dai ◽

Gyungse Park ◽

Marcus W. Wright ◽

Marissa Adams ◽

Steven A. Akman ◽

...

Keyword(s):

Ochratoxin A ◽

Glutathione Conjugate

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Characterization of the glutathione conjugate of the semisynthetic flavonoid monoHER

Free Radical Biology and Medicine ◽

10.1016/j.freeradbiomed.2009.02.031 ◽

2009 ◽

Vol 46 (12) ◽

pp. 1567-1573 ◽

Cited By ~ 15

Author(s):

Hilde Jacobs ◽

Wim J.F. van der Vijgh ◽

Ger H. Koek ◽

Guy J.J. Draaisma ◽

Mohamed Moalin ◽

...

Keyword(s):

Glutathione Conjugate

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Electrochemical Oxidation of Troglitazone: Identification and Characterization of the Major Reactive Metabolite in Liver Microsomes

Chemical Research in Toxicology ◽

10.1021/tx8002214 ◽

2008 ◽

Vol 21 (10) ◽

pp. 2035-2041 ◽

Cited By ~ 34

Author(s):

Kim G. Madsen ◽

Gunnar Grönberg ◽

Christian Skonberg ◽

Ulrik Jurva ◽

Steen H. Hansen ◽

...

Keyword(s):

Electrochemical Oxidation ◽

Liver Microsomes ◽

Reactive Metabolite ◽

Identification And Characterization

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Characterization of Nucleoside Adducts ofcis-2-Butene-1,4-dial, a Reactive Metabolite of Furan

Chemical Research in Toxicology ◽

10.1021/tx0101402 ◽

2002 ◽

Vol 15 (3) ◽

pp. 373-379 ◽

Cited By ~ 74

Author(s):

Michael C. Byrns ◽

Daniel P. Predecki ◽

Lisa A. Peterson

Keyword(s):

Reactive Metabolite ◽

Nucleoside Adducts

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