Blood Folate Status and Expression of Proteins Involved in Immune Function, Inflammation, and Coagulation: Biochemical and Proteomic Changes in the Plasma of Humans in Response to Long-Term Synthetic Folic Acid Supplementation

2010 ◽  
Vol 9 (4) ◽  
pp. 1941-1950 ◽  
Author(s):  
Susan J. Duthie ◽  
Graham Horgan ◽  
Baukje de Roos ◽  
Garry Rucklidge ◽  
Martin Reid ◽  
...  
Keyword(s):  
Folic Acid ◽  
Immune Function ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Folate Status

scholarly journals The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST)

2018 ◽  
Vol 47 (3) ◽  
pp. 928-937 ◽  
Author(s):  
Rebecca C Richmond ◽  
Gemma C Sharp ◽  
Georgia Herbert ◽  
Charlotte Atkinson ◽  
Caroline Taylor ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Long Term Impact ◽  
In Pregnancy

Chronic ethanol exposure and folic acid supplementation: Fetal growth and folate status in the maternal and fetal guinea pig

2011 ◽  
Vol 31 (4) ◽  
pp. 500-506 ◽  
Author(s):  
Amy J. Hewitt ◽  
Amber L. Knuff ◽  
Matthew J. Jefkins ◽  
Christine P. Collier ◽  
James N. Reynolds ◽  
...  
Keyword(s):  
Folic Acid ◽  
Guinea Pig ◽  
Fetal Growth ◽  
Folic Acid Supplementation ◽  
Ethanol Exposure ◽  
Chronic Ethanol ◽  
Acid Supplementation ◽  
Folate Status ◽  
Chronic Ethanol Exposure

scholarly journals Prenatal folic acid supplementation and folate status in early pregnancy: ECLIPSES study

2021 ◽  
pp. 1-25
Author(s):  
Lucía Iglesias-Vázquez ◽  
Núria Serrat ◽  
Cristina Bedmar ◽  
Meritxell Pallejà-Millán ◽  
Victoria Arija
Keyword(s):  
Folic Acid ◽  
Low Socioeconomic Status ◽  
Early Pregnancy ◽  
Folate Deficiency ◽  
Folic Acid Supplementation ◽  
Multivariate Statistical ◽  
Cross Sectional ◽  
Acid Supplementation ◽  
Pregnancy Planning ◽  
Folate Status

Abstract This research evaluates the prevalence of inadequate folate status in early pregnancy, the pattern of prenatal folic acid (FA) supplementation and associated factors in Spanish pregnant women from the ECLIPSES study, which included 791 participants prior gestational week 12. A cross-sectional evaluation of red blood cell (RBC) folate levels was performed at recruitment and used to calculate the prevalence of folate deficiency (RBC folate<340 nmol/L) and insufficiency (RBC folate<906 nmol/L). Sociodemographic and lifestyle data, as well as information on prenatal FA supplementation were recorded. Descriptive and multivariate statistical analyses were performed. The prevalence of folate deficiency and insufficiency were 9.6% and 86.5%, respectively. Most of women used prenatal FA supplements but only 6.3% did so as recommended. Supplementation with FA during the periconceptional period abolished folate deficiency and reduced folate insufficiency. Prenatal folic acid supplementation with ≥1000 µg/d in periconceptional time and pregnancy planning increased RBC folate levels. The main risk factor for folate insufficiency in early pregnancy were getting prenatal FA supplementation out of the periconceptional time (OR 3.32, 95%CI 1.02–15.36), while for folate deficiency they were young age (OR 2.02, 95%CI 1.05–3.99), and smoking (OR 2.39, 95%CI 1.30–4.37). In addition, social and ethnic differences according to folate status were also identified. As conclusion, periconceptional FA use is crucial for achieving optimal folate levels in early pregnancy. Pregnancy planning should focus on young women, smokers, those with low consumption of folate-rich foods, low socioeconomic status or from ethnic minorities.

scholarly journals Folic acid supplementation for 12 weeks modifies gene expression in leukocytes in men with low folate status

2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Ligi Paul ◽  
Cristina Razzari ◽  
Francesca Sampietro ◽  
Gessica Fontana ◽  
Isabella Fermo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Folate Status

Effect of Folic Acid Supplementation on Seizure Control in Epileptic Children Receiving Long Term Antiepileptic Therapy

2018 ◽  
Vol 85 (7) ◽  
pp. 493-497 ◽  
Author(s):  
Bindu Deopa ◽  
Manish Parakh ◽  
Pawan Dara ◽  
Vikas Payal ◽  
Kapil Chordiya ◽  
...  
Keyword(s):  
Folic Acid ◽  
Seizure Control ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Antiepileptic Therapy ◽  
Epileptic Children

scholarly journals Effect of long-term low-dose folic acid supplementation on degree of total homocysteine-lowering: major effect modifiers

2018 ◽  
Vol 120 (10) ◽  
pp. 1122-1130 ◽  
Author(s):  
Binyan Wang ◽  
Hongxu Wu ◽  
Youbao Li ◽  
Qianyun Ban ◽  
Xiao Huang ◽  
...  
Keyword(s):  
Folic Acid ◽  
Low Dose ◽  
Methylenetetrahydrofolate Reductase ◽  
Smoking Status ◽  
Folic Acid Supplementation ◽  
Major Effect ◽  
Acid Supplementation ◽  
Total Homocysteine ◽  
Using Data

AbstractWe sought to examine the potential modifiers in the association between long-term low-dose folic acid supplementation and the reduction of serum total homocysteine (tHcy) among hypertensive patients, using data from the China Stroke Primary Prevention Trial (CSPPT). This analysis included 16 867 participants who had complete data on tHcy measurements at both the baseline and exit visit. After a median treatment period of 4·5 years, folic acid treatment significantly reduced the tHcy levels by 1·6 μmol/l (95 % CI 1·4, 1·8). More importantly, after adjustment for baseline tHcy and other important covariates, a greater degree of tHcy reduction was observed in certain subgroups: males, the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype, higher baseline tHcy levels (≥12·5 (median) v. <12·5 μmol/l), lower folate levels (<8·0 (median) v. ≥8·0 ng/ml), estimated glomerular filtration rate (eGFR) <60 ml/min per 1·73 m2 (v. 60–<90 and ≥90 ml/min per 1·73 m2), ever smokers and concomitant use of diuretics (P for all interactions <0·05). The degree of tHcy reduction associated with long-term folic acid supplementation can be significantly affected by sex, MTHFR C677T genotypes, baseline folate, tHcy, eGFR levels and smoking status.

The impact of folate status and folic acid supplementation on the micronucleus frequency in human erythrocytes

2006 ◽  
Vol 603 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Lilianne Abramsson-Zetterberg ◽  
Louise J.K. Durling ◽  
Fan Yang-Wallentin ◽  
Elisabet Rytter ◽  
Bengt Vessby
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Human Erythrocytes ◽  
Acid Supplementation ◽  
Folate Status ◽  
Micronucleus Frequency ◽  
The Impact
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