scholarly journals The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST)

2018 ◽  
Vol 47 (3) ◽  
pp. 928-937 ◽  
Author(s):  
Rebecca C Richmond ◽  
Gemma C Sharp ◽  
Georgia Herbert ◽  
Charlotte Atkinson ◽  
Caroline Taylor ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
Long Term Impact ◽  
In Pregnancy

scholarly journals Effect of continued folic acid supplementation beyond the first trimester of pregnancy on cognitive performance in the child: a follow-up study from a randomized controlled trial (FASSTT Offspring Trial)

BMC Medicine ◽  
2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Helene McNulty ◽  
Mark Rollins ◽  
Tony Cassidy ◽  
Aoife Caffrey ◽  
Barry Marshall ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cognitive Performance ◽  
Controlled Trial ◽  
First Trimester ◽  
Folic Acid Supplementation ◽  
Verbal Iq ◽  
Acid Supplementation ◽  
Randomized Controlled ◽  
In Pregnancy

Abstract Background Periconceptional folic acid prevents neural tube defects (NTDs), but it is uncertain whether there are benefits for offspring neurodevelopment arising from continued maternal folic acid supplementation beyond the first trimester. We investigated the effect of folic acid supplementation during trimesters 2 and 3 of pregnancy on cognitive performance in the child. Methods We followed up the children of mothers who had participated in a randomized controlled trial in 2006/2007 of Folic Acid Supplementation during the Second and Third Trimesters (FASSTT) and received 400 μg/d folic acid or placebo from the 14th gestational week until the end of pregnancy. Cognitive performance of children at 7 years was evaluated using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) and at 3 years using the Bayley’s Scale of Infant and Toddler Development (BSITD-III). Results From a total of 119 potential mother-child pairs, 70 children completed the assessment at age 7 years, and 39 at age 3 years. At 7 years, the children of folic acid treated mothers scored significantly higher than the placebo group in word reasoning: mean 13.3 (95% CI 12.4–14.2) versus 11.9 (95% CI 11.0–12.8); p = 0.027; at 3 years, they scored significantly higher in cognition: 10.3 (95% CI 9.3–11.3) versus 9.5 (95% CI 8.8–10.2); p = 0.040. At both time points, greater proportions of children from folic acid treated mothers compared with placebo had cognitive scores above the median values of 10 (girls and boys) for the BSITD-III, and 24.5 (girls) and 21.5 (boys) for the WPPSI-III tests. When compared with a nationally representative sample of British children at 7 years, WPPSI-III test scores were higher in children from folic acid treated mothers for verbal IQ (p < 0.001), performance IQ (p = 0.035), general language (p = 0.002), and full scale IQ (p = 0.001), whereas comparison of the placebo group with British children showed smaller differences in scores for verbal IQ (p = 0.034) and full scale IQ (p = 0.017) and no differences for performance IQ or general language. Conclusions Continued folic acid supplementation in pregnancy beyond the early period recommended to prevent NTD may have beneficial effects on child cognitive development. Further randomized trials in pregnancy with follow-up in childhood are warranted. Trial registration ISRCTN ISRCTN19917787. Registered 15 May 2013.

scholarly journals Folic acid in pregnancy and mortality from cancer and cardiovascular disease: further follow-up of the Aberdeen folic acid supplementation trial

2015 ◽  
Vol 69 (8) ◽  
pp. 789-794 ◽  
Author(s):  
Caroline M Taylor ◽  
Charlotte Atkinson ◽  
Chris Penfold ◽  
Sohinee Bhattacharya ◽  
Doris Campbell ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Acid Supplementation ◽  
In Pregnancy

scholarly journals Effects of maternal folic acid supplementation during the second and third trimesters of pregnancy on neurocognitive development in the child: an 11-year follow-up from a randomised controlled trial

BMC Medicine ◽  
2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Aoife Caffrey ◽  
Helene McNulty ◽  
Mark Rollins ◽  
Girijesh Prasad ◽  
Pramod Gaur ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cognitive Performance ◽  
Processing Speed ◽  
Randomised Trial ◽  
Folic Acid Supplementation ◽  
Verbal Comprehension ◽  
Neurocognitive Development ◽  
Acid Supplementation ◽  
In Pregnancy

Abstract Background Maternal folic acid (FA) supplementation before and in early pregnancy prevents neural tube defects (NTD), but it is uncertain whether continuing FA after the first trimester has benefits on offspring health. We aimed to evaluate the effect of FA supplementation throughout pregnancy on cognitive performance and brain function in the child. Methods Follow-up investigation of 11-year-old children, residing in Northern Ireland, whose mothers had participated in a randomised trial of Folic Acid Supplementation in the Second and Third Trimesters (FASSTT) in pregnancy and received 400 μg/day FA or placebo from the 14th gestational week. Cognitive performance (Full Scale Intelligence Quotient, Verbal Comprehension, Working Memory, Perceptual Reasoning, and Processing Speed) was assessed using the Wechsler Intelligence Scale for Children. Neuronal function was assessed using magnetoencephalographic (MEG) brain imaging. Results Of 119 mother-child pairs in the FASSTT trial, 68 children were assessed for neurocognitive performance at 11-year follow-up (Dec 2017 to Nov 2018). Children of mothers randomised to FA compared with placebo scored significantly higher in two Processing Speed tests, i.e. symbol search (mean difference 2.9 points, 95% CI 0.3 to 5.5, p = 0.03) and cancellation (11.3 points, 2.5 to 20.1, p = 0.04), whereas the positive effect on Verbal Comprehension was significant in girls only (6.5 points, 1.2 to 11.8, p = 0.03). MEG assessment of neuronal responses to a language task showed increased power at the Beta (13–30 Hz, p = 0.01) and High Gamma (49–70 Hz, p = 0.04) bands in children from FA-supplemented mothers, suggesting more efficient semantic processing of language. Conclusions Continued FA supplementation in pregnancy beyond the early period currently recommended to prevent NTD can benefit neurocognitive development of the child. MEG provides a non-invasive tool in paediatric research to objectively assess functional brain activity in response to nutrition and other interventions. Trial registration ISRCTN ISRCTN19917787. Registered on 15 May 2013.

scholarly journals Analysis of Locus‐Specific DNA Methylation in Response to Chronic Folic Acid Supplementation and Withdrawal in Chinese Women

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jason O Brant ◽  
Jiang‐Hui Zhu ◽  
Krista Crider ◽  
R J Berry ◽  
Ling Hao ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Chinese Women ◽  
Folic Acid Supplementation ◽  
Acid Supplementation

scholarly journals No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine

PLoS ONE ◽  
2011 ◽  
Vol 6 (9) ◽  
pp. e24976 ◽  
Author(s):  
Audrey Y. Jung ◽  
Yvo Smulders ◽  
Petra Verhoef ◽  
Frans J. Kok ◽  
Henk Blom ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Folic Acid ◽  
Folic Acid Supplementation ◽  
Global Dna Methylation ◽  
Men And Women ◽  
Acid Supplementation

scholarly journals Effect of High Dose Folic Acid Supplementation in Pregnancy on Pre-eclampsia (FACT)

2019 ◽  
Vol 74 (2) ◽  
pp. 68-70 ◽  
Author(s):  
Shi Wu Wen ◽  
Ruth Rennicks White ◽  
Natalie Rybak ◽  
Laura M. Gaudet ◽  
Stephen Robson ◽  
...  
Keyword(s):  
Folic Acid ◽  
Folic Acid Supplementation ◽  
High Dose ◽  
Acid Supplementation ◽  
In Pregnancy
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