scholarly journals Rapid and Deep Proteomes by Faster Sequencing on a Benchtop Quadrupole Ultra-High-Field Orbitrap Mass Spectrometer

2014 ◽  
Vol 13 (12) ◽  
pp. 6187-6195 ◽  
Author(s):  
Christian D. Kelstrup ◽  
Rosa R. Jersie-Christensen ◽  
Tanveer S. Batth ◽  
Tabiwang N. Arrey ◽  
Andreas Kuehn ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
High Field ◽  
Ultra High Field ◽  
Orbitrap Mass Spectrometer

scholarly journals The Q Exactive HF, a Benchtop Mass Spectrometer with a Pre-filter, High-performance Quadrupole and an Ultra-high-field Orbitrap Analyzer

2014 ◽  
Vol 13 (12) ◽  
pp. 3698-3708 ◽  
Author(s):  
Richard Alexander Scheltema ◽  
Jan-Peter Hauschild ◽  
Oliver Lange ◽  
Daniel Hornburg ◽  
Eduard Denisov ◽  
...  
Keyword(s):  
Mass Spectrometer ◽  
High Field ◽  
High Performance ◽  
Ultra High Field ◽  
Q Exactive ◽  
Orbitrap Analyzer

Characterization of a high field Orbitrap mass spectrometer for proteome analysis

PROTEOMICS ◽  
2013 ◽  
Vol 13 (17) ◽  
pp. 2552-2562 ◽  
Author(s):  
Fiona Pachl ◽  
Benjamin Ruprecht ◽  
Simone Lemeer ◽  
Bernhard Kuster
Keyword(s):  
Mass Spectrometer ◽  
High Field ◽  
Proteome Analysis ◽  
Orbitrap Mass Spectrometer

scholarly journals Global Phosphoproteome Analysis Using High-Field Asymmetric Waveform Ion Mobility Spectrometry on a Hybrid Orbitrap Mass Spectrometer

2020 ◽  
Vol 92 (24) ◽  
pp. 15959-15967
Author(s):  
Laura K. Muehlbauer ◽  
Alexander S. Hebert ◽  
Michael S. Westphall ◽  
Evgenia Shishkova ◽  
Joshua J. Coon
Keyword(s):  
Mass Spectrometer ◽  
Ion Mobility Spectrometry ◽  
Ion Mobility ◽  
High Field ◽  
Asymmetric Waveform ◽  
Orbitrap Mass Spectrometer

scholarly journals Ultra-high-field 7-T MRI in multiple sclerosis and other demyelinating diseases: from pathology to clinical practice

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Nicolo’ Bruschi ◽  
Giacomo Boffa ◽  
Matilde Inglese
Keyword(s):  
Multiple Sclerosis ◽  
High Field ◽  
Neurological Diseases ◽  
Lesion Detection ◽  
Demyelinating Diseases ◽  
Metabolic Imaging ◽  
Central Vein ◽  
Ultra High Field ◽  
Functional Features

Abstract Magnetic resonance imaging (MRI) is essential for the early diagnosis of multiple sclerosis (MS), for investigating the disease pathophysiology, and for discriminating MS from other neurological diseases. Ultra-high-field strength (7-T) MRI provides a new tool for studying MS and other demyelinating diseases both in research and in clinical settings. We present an overview of 7-T MRI application in MS focusing on increased sensitivity and specificity for lesion detection and characterisation in the brain and spinal cord, central vein sign identification, and leptomeningeal enhancement detection. We also discuss the role of 7-T MRI in improving our understanding of MS pathophysiology with the aid of metabolic imaging. In addition, we present 7-T MRI applications in other demyelinating diseases. 7-T MRI allows better detection of the anatomical, pathological, and functional features of MS, thus improving our understanding of MS pathology in vivo. 7-T MRI also represents a potential tool for earlier and more accurate diagnosis.

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