scholarly journals Novel Multimetabolite Prediction of Walnut Consumption by a Urinary Biomarker Model in a Free-Living Population: the PREDIMED Study

2014 ◽  
Vol 13 (7) ◽  
pp. 3476-3483 ◽  
Author(s):  
Mar Garcia-Aloy ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Sara Tulipani ◽  
Ramon Estruch ◽  
...  
Keyword(s):  
Urinary Biomarker ◽  
Free Living ◽  
Predimed Study

Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study

2009 ◽  
Vol 46 (12) ◽  
pp. 1562-1566 ◽  
Author(s):  
Raul Zamora-Ros ◽  
Mireia Urpí-Sardà ◽  
Rosa M. Lamuela-Raventós ◽  
Ramon Estruch ◽  
Miguel Ángel Martínez-González ◽  
...  
Keyword(s):  
Free Living ◽  
Predimed Study

scholarly journals Nutrimetabolomics fingerprinting to identify biomarkers of bread exposure in a free-living population from the PREDIMED study cohort

Metabolomics ◽  
2014 ◽  
Vol 11 (1) ◽  
pp. 155-165 ◽  
Author(s):  
Mar Garcia-Aloy ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Sara Tulipani ◽  
Jordi Salas-Salvadó ◽  
...  
Keyword(s):  
Study Cohort ◽  
Free Living ◽  
Predimed Study

scholarly journals Validation of low-calorie sweetener(LCS)-focused food frequency questionnaire for assessment of intakes in a free-living adult population: preliminary results

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
A. Dunne ◽  
M. Mulhern ◽  
A. M. Gallagher ◽  
C. Logue
Keyword(s):  
Dietary Intake ◽  
Food Frequency Questionnaire ◽  
Reference Method ◽  
Free Sugar ◽  
Urinary Biomarker ◽  
Food Diary ◽  
Free Living ◽  
Food Frequency ◽  
Low Calorie ◽  
Preliminary Results

AbstractBoth obesity and type 2 diabetes mellitus have been associated with excessive free sugar consumption. Increasingly, LCS are used to replace free sugar to reduce the energy density of the diet, whilst maintaining diet palatability. However, while experimental data suggest a beneficial effect of LCS on weight management and glycaemic control, data from free-living populations are contradictory and primarily use reported intakes of low-calorie sweetened beverages as a marker of overall LCS consumption. Therefore, a dietary assessment tool that reliably assesses overall LCS consumption and is applicable in large-scale epidemiological studies is desirable. This study aimed to validate an LCS-focused food frequency questionnaire (FFQ) for assessing habitual dietary intake of the LCS using the method of triads. Healthy adults were recruited at Ulster University, Coleraine (n = 120). A 65-item FFQ and a 4-day food diary (FD) were used to assess dietary intake of LCS with amounts based on maximum permitted levels for foods and beverages as per EU legislation. A novel urinary biomarker approach, developed by this research group, was used to objectively assess consumption of 5 commonly used LCS(1). The method of triads was used to validate the FFQ by evaluating the correlations between the FFQ, FD and the urinary biomarkers (reference method). A total of 110 participants (51 males, 59 females) completed all analyses. Median (IQR) total LCS consumption estimated from the FFQ, FD and urinary biomarker was 116.8 (24.9–303.3) mg/d, 27.8 (0.0–247.3) mg/d and 5.0 (0.6–34.9) mg/d respectively. Moderate correlations were observed between the FD and urinary biomarker (r = 0.471; P < 0.001) and between the FFQ and FD (r = 0.471; P < 0.001). There was a low correlation between the FFQ and urinary biomarker (r = 0.291; P < 0.001). Using the method of triads, the overall validity co-efficient for the FFQ was moderate (0.54). These preliminary results indicate potential for this LCS-focused FFQ as a method of assessing LCS consumption in free-living populations. However, as maximum permitted levels of LCS in foods and beverages were used to estimate LCS consumption from the FFQ and FD, they are likely to significantly overestimate actual LCS intakes as compared to the more reliable biomarker approach. Therefore, the FFQ ability to categorise individuals into low-, medium- and high LCS consumers will be tested. Further analysis is ongoing to assess the completeness of urine collections using PABA analysis and will also focus on individual LCS intake.

scholarly journals An NMR metabolomics approach reveals a combined-biomarkers model in a wine interventional trial with validation in free-living individuals of the PREDIMED study

Metabolomics ◽  
2014 ◽  
Vol 11 (4) ◽  
pp. 797-806 ◽  
Author(s):  
Rosa Vázquez-Fresno ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Olha Khymenets ◽  
Mònica Bulló ◽  
...  
Keyword(s):  
Free Living ◽  
Nmr Metabolomics ◽  
Interventional Trial ◽  
Predimed Study

scholarly journals A metabolomics-driven approach to predict cocoa product consumption by designing a multimetabolite biomarker model in free-living subjects from the PREDIMED study

2014 ◽  
Vol 59 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Mar Garcia-Aloy ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Olga Jáuregui ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Free Living ◽  
Product Consumption ◽  
Predimed Study ◽  
Cocoa Product

Ultrastructure of neuromuscular relationships in the canine heartworm (dirofilaria immitis)

1986 ◽  
Vol 44 ◽  
pp. 278-279
Author(s):  
W. L. Steffens ◽  
Nancy B. Roberts ◽  
J. M. Bowen
Keyword(s):  
Dirofilaria Immitis ◽  
Domestic Dogs ◽  
Structural Description ◽  
Pharmacological Effects ◽  
Free Living ◽  
Canine Heartworm ◽  
The World ◽  
Synaptic Region ◽  
Muscle Innervation ◽  
Insight Into

The canine heartworm is a common and serious nematode parasite of domestic dogs in many parts of the world. Although nematode neuroanatomy is fairly well documented, the emphasis has been on sensory anatomy and primarily in free-living soil species and ascarids. Lee and Miller reported on the muscular anatomy in the heartworm, but provided little insight into the peripheral nervous system or myoneural relationships. The classical fine-structural description of nematode muscle innervation is Rosenbluth's earlier work in Ascaris. Since the pharmacological effects of some nematacides currently being developed are neuromuscular in nature, a better understanding of heartworm myoneural anatomy, particularly in reference to the synaptic region is warranted.

Lead and lead toxicity in domestic and free living birds

2003 ◽  
Vol 32 (1) ◽  
pp. 3-13 ◽  
Author(s):  
N. De Francisco ◽  
N. De Francisco ◽  
N. De Francisco
Keyword(s):  
Lead Toxicity ◽  
Free Living

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

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