scholarly journals A metabolomics-driven approach to predict cocoa product consumption by designing a multimetabolite biomarker model in free-living subjects from the PREDIMED study

2014 ◽  
Vol 59 (2) ◽  
pp. 212-220 ◽  
Author(s):  
Mar Garcia-Aloy ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Olga Jáuregui ◽  
Dolores Corella ◽  
...  
Keyword(s):  
Free Living ◽  
Product Consumption ◽  
Predimed Study ◽  
Cocoa Product

Resveratrol metabolites in urine as a biomarker of wine intake in free-living subjects: The PREDIMED Study

2009 ◽  
Vol 46 (12) ◽  
pp. 1562-1566 ◽  
Author(s):  
Raul Zamora-Ros ◽  
Mireia Urpí-Sardà ◽  
Rosa M. Lamuela-Raventós ◽  
Ramon Estruch ◽  
Miguel Ángel Martínez-González ◽  
...  
Keyword(s):  
Free Living ◽  
Predimed Study

scholarly journals Nutrimetabolomics fingerprinting to identify biomarkers of bread exposure in a free-living population from the PREDIMED study cohort

Metabolomics ◽  
2014 ◽  
Vol 11 (1) ◽  
pp. 155-165 ◽  
Author(s):  
Mar Garcia-Aloy ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Sara Tulipani ◽  
Jordi Salas-Salvadó ◽  
...  
Keyword(s):  
Study Cohort ◽  
Free Living ◽  
Predimed Study

scholarly journals The Health Effects of Chocolate and Cocoa: A Systematic Review

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 2909
Author(s):  
Terence Yew Chin Tan ◽  
Xin Yi Lim ◽  
Julie Hsiao Hui Yeo ◽  
Shaun Wen Huey Lee ◽  
Nai Ming Lai
Keyword(s):  
Quality Of Life ◽  
Health Effects ◽  
Human Consumption ◽  
Cochrane Central Register ◽  
Product Consumption ◽  
Central Register ◽  
Significant Difference ◽  
The Many ◽  
Cocoa Product

Chocolate has a history of human consumption tracing back to 400 AD and is rich in polyphenols such as catechins, anthocyanidins, and pro anthocyanidins. As chocolate and cocoa product consumption, along with interest in them as functional foods, increases worldwide, there is a need to systematically and critically appraise the available clinical evidence on their health effects. A systematic search was conducted on electronic databases such as MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) using a search strategy and keywords. Among the many health effects assessed on several outcomes (including skin, cardiovascular, anthropometric, cognitive, and quality of life), we found that compared to controls, chocolate or cocoa product consumption significantly improved lipid profiles (triglycerides), while the effects of chocolate on all other outcome parameters were not significantly different. In conclusion, low-to-moderate-quality evidence with short duration of research (majority 4–6 weeks) showed no significant difference between the effects of chocolate and control groups on parameters related to skin, blood pressure, lipid profile, cognitive function, anthropometry, blood glucose, and quality of life regardless of form, dose, and duration among healthy individuals. It was generally well accepted by study subjects, with gastrointestinal disturbances and unpalatability being the most reported concerns.

scholarly journals Novel Multimetabolite Prediction of Walnut Consumption by a Urinary Biomarker Model in a Free-Living Population: the PREDIMED Study

2014 ◽  
Vol 13 (7) ◽  
pp. 3476-3483 ◽  
Author(s):  
Mar Garcia-Aloy ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Sara Tulipani ◽  
Ramon Estruch ◽  
...  
Keyword(s):  
Urinary Biomarker ◽  
Free Living ◽  
Predimed Study

scholarly journals An NMR metabolomics approach reveals a combined-biomarkers model in a wine interventional trial with validation in free-living individuals of the PREDIMED study

Metabolomics ◽  
2014 ◽  
Vol 11 (4) ◽  
pp. 797-806 ◽  
Author(s):  
Rosa Vázquez-Fresno ◽  
Rafael Llorach ◽  
Mireia Urpi-Sarda ◽  
Olha Khymenets ◽  
Mònica Bulló ◽  
...  
Keyword(s):  
Free Living ◽  
Nmr Metabolomics ◽  
Interventional Trial ◽  
Predimed Study

Ultrastructure of neuromuscular relationships in the canine heartworm (dirofilaria immitis)

1986 ◽  
Vol 44 ◽  
pp. 278-279
Author(s):  
W. L. Steffens ◽  
Nancy B. Roberts ◽  
J. M. Bowen
Keyword(s):  
Dirofilaria Immitis ◽  
Domestic Dogs ◽  
Structural Description ◽  
Pharmacological Effects ◽  
Free Living ◽  
Canine Heartworm ◽  
The World ◽  
Synaptic Region ◽  
Muscle Innervation ◽  
Insight Into

The canine heartworm is a common and serious nematode parasite of domestic dogs in many parts of the world. Although nematode neuroanatomy is fairly well documented, the emphasis has been on sensory anatomy and primarily in free-living soil species and ascarids. Lee and Miller reported on the muscular anatomy in the heartworm, but provided little insight into the peripheral nervous system or myoneural relationships. The classical fine-structural description of nematode muscle innervation is Rosenbluth's earlier work in Ascaris. Since the pharmacological effects of some nematacides currently being developed are neuromuscular in nature, a better understanding of heartworm myoneural anatomy, particularly in reference to the synaptic region is warranted.

Lead and lead toxicity in domestic and free living birds

2003 ◽  
Vol 32 (1) ◽  
pp. 3-13 ◽  
Author(s):  
N. De Francisco ◽  
N. De Francisco ◽  
N. De Francisco
Keyword(s):  
Lead Toxicity ◽  
Free Living

Platelet Aggregation in Finnish Men and Its Relation to Fatty Acids in Platelets, Plasma and Adipose Tissue

1985 ◽  
Vol 54 (03) ◽  
pp. 563-569 ◽  
Author(s):  
M K Salo ◽  
E Vartiainen ◽  
P Puska ◽  
T Nikkari
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Acid Composition ◽  
Saturated Fatty Acids ◽  
Free Living ◽  
Ω3 Fatty Acids ◽  
Induced Aggregation

SummaryPlatelet aggregation and its relation to fatty acid composition of platelets, plasma and adipose tissue was determined in 196 randomly selected, free-living, 40-49-year-old men in two regions of Finland (east and southwest) with a nearly twofold difference in the IHD rate.There were no significant east-southwest differences in platelet aggregation induced with ADP, thrombin or epinephrine. ADP-induced platelet secondary aggregation showed significant negative associations with all C20-C22 ω3-fatty acids in platelets (r = -0.26 - -0.40) and with the platelet 20: 5ω3/20: 4ω 6 and ω3/ ω6 ratios, but significant positive correlations with the contents of 18:2 in adipose tissue (r = 0.20) and plasma triglycerides (TG) (r = 0.29). Epinephrine-induced aggregation correlated negatively with 20: 5ω 3 in plasma cholesteryl esters (CE) (r = -0.23) and TG (r = -0.29), and positively with the total percentage of saturated fatty acids in platelets (r = 0.33), but had no significant correlations with any of the ω6-fatty acids. Thrombin-induced aggregation correlated negatively with the ω3/6ω ratio in adipose tissue (r = -0.25) and the 20: 3ω6/20: 4ω 6 ratio in plasma CE (r = -0.27) and free fatty acids (FFA) (r = -0.23), and positively with adipose tissue 18:2 (r = 0.23) and 20:4ω6 (r = 0.22) in plasma phospholipids (PL).The percentages of prostanoid precursors in platelet lipids, i. e. 20: 3ω 6, 20: 4ω 6 and 20 :5ω 3, correlated best with the same fatty acids in plasma CE (r = 0.32 - 0.77) and PL (r = 0.28 - 0.74). Platelet 20: 5ω 3 had highly significant negative correlations with the percentage of 18:2 in adipose tissue and all plasma lipid fractions (r = -0.35 - -0.44).These results suggest that, among a free-living population, relatively small changes in the fatty acid composition of plasma and platelets may be reflected in significant differences in platelet aggregation, and that an increase in linoleate-rich vegetable fat in the diet may not affect platelet function favourably unless it is accompanied by an adequate supply of ω3 fatty acids.

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