scholarly journals Quantitative Proteomics Reveals a “Poised Quiescence” Cellular State after Triggering the DNA Replication Origin Activation Checkpoint

2010 ◽  
Vol 9 (10) ◽  
pp. 5445-5460 ◽  
Author(s):  
Claire Mulvey ◽  
Slavica Tudzarova ◽  
Mark Crawford ◽  
Gareth H. Williams ◽  
Kai Stoeber ◽  
...  
Keyword(s):  
Dna Replication ◽  
Quantitative Proteomics ◽  
Replication Origin ◽  
Origin Activation ◽  
Dna Replication Origin

scholarly journals Subcellular Proteomics Reveals a Role for Nucleo-cytoplasmic Trafficking at the DNA Replication Origin Activation Checkpoint

2013 ◽  
Vol 12 (3) ◽  
pp. 1436-1453 ◽  
Author(s):  
Claire M. Mulvey ◽  
Slavica Tudzarova ◽  
Mark Crawford ◽  
Gareth H. Williams ◽  
Kai Stoeber ◽  
...  
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Origin Activation ◽  
Dna Replication Origin ◽  
Subcellular Proteomics

scholarly journals Chromatin‐dependent and ‐independent regulation of DNA replication origin activation in budding yeast

EMBO Reports ◽  
2012 ◽  
Vol 14 (2) ◽  
pp. 191-198 ◽  
Author(s):  
Marko Lõoke ◽  
Kersti Kristjuhan ◽  
Signe Värv ◽  
Arnold Kristjuhan
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Budding Yeast ◽  
Origin Activation ◽  
Dna Replication Origin

scholarly journals Universal temporal rate of DNA replication origin firing: A balance between origin activation and passivation

2018 ◽  
Author(s):  
Jean-Michel Arbona ◽  
Arach Goldar ◽  
Olivier Hyrien ◽  
Alain Arneodo ◽  
Benjamin Audit
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Replication Fork ◽  
Time Dependent ◽  
Origin Firing ◽  
Dependent Rate ◽  
Origin Activation ◽  
Normal Diffusion ◽  
Dna Replication Origin ◽  
Temporal Rate

AbstractThe time-dependent rate I(t) of origin firing per length of unreplicated DNA presents a universal bell shape in eukaryotes that has been interpreted as the result of a complex time-evolving interaction between origins and limiting firing factors. Here we show that a normal diffusion of replication fork components towards localized potential replication origins (p-oris) can more simply account for the I(t) universal bell shape, as a consequence of a competition between the origin firing time and the time needed to replicate DNA separating two neighboring p-oris. We predict the I(t) maximal value to be the product of the replication fork speed with the squared p-ori density. We show that this relation is robustly observed in simulations and in experimental data for several eukaryotes. Our work underlines that fork-component recycling and potential origins localization are sufficient spatial ingredients to explain the universality of DNA replication kinetics.

scholarly journals The eukaryotic bell-shaped temporal rate of DNA replication origin firing emanates from a balance between origin activation and passivation

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Jean-Michel Arbona ◽  
Arach Goldar ◽  
Olivier Hyrien ◽  
Alain Arneodo ◽  
Benjamin Audit
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Replication Fork ◽  
Time Dependent ◽  
Origin Firing ◽  
Dependent Rate ◽  
Origin Activation ◽  
Normal Diffusion ◽  
Dna Replication Origin ◽  
Temporal Rate

The time-dependent rate I(t) of origin firing per length of unreplicated DNA presents a universal bell shape in eukaryotes that has been interpreted as the result of a complex time-evolving interaction between origins and limiting firing factors. Here, we show that a normal diffusion of replication fork components towards localized potential replication origins (p-oris) can more simply account for the I(t) universal bell shape, as a consequence of a competition between the origin firing time and the time needed to replicate DNA separating two neighboring p-oris. We predict the I(t) maximal value to be the product of the replication fork speed with the squared p-ori density. We show that this relation is robustly observed in simulations and in experimental data for several eukaryotes. Our work underlines that fork-component recycling and potential origins localization are sufficient spatial ingredients to explain the universality of DNA replication kinetics.

DNA replication origin activation in space and time

2015 ◽  
Vol 16 (6) ◽  
pp. 360-374 ◽  
Author(s):  
Michalis Fragkos ◽  
Olivier Ganier ◽  
Philippe Coulombe ◽  
Marcel Méchali
Keyword(s):  
Dna Replication ◽  
Replication Origin ◽  
Space And Time ◽  
Origin Activation ◽  
Dna Replication Origin

scholarly journals Human RIF 1 and protein phosphatase 1 stimulate DNA replication origin licensing but suppress origin activation

EMBO Reports ◽  
2017 ◽  
Vol 18 (3) ◽  
pp. 403-419 ◽  
Author(s):  
Shin‐ichiro Hiraga ◽  
Tony Ly ◽  
Javier Garzón ◽  
Zuzana Hořejší ◽  
Yoshi‐nobu Ohkubo ◽  
...  
Keyword(s):  
Dna Replication ◽  
Protein Phosphatase ◽  
Replication Origin ◽  
Protein Phosphatase 1 ◽  
Origin Activation ◽  
Origin Licensing ◽  
Dna Replication Origin
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