Targeted In-Gel MRM: A Hypothesis Driven Approach for Colorectal Cancer Biomarker Discovery in Human Feces

2010 ◽  
Vol 9 (9) ◽  
pp. 4346-4355 ◽  
Author(s):  
Ching-Seng Ang ◽  
Edouard C. Nice
Keyword(s):  
Colorectal Cancer ◽  
Biomarker Discovery ◽  
Cancer Biomarker ◽  
Human Feces

W1897 Colorectal Cancer Biomarker Discovery Using Quantitative Proteomics

2009 ◽  
Vol 136 (5) ◽  
pp. A-749
Author(s):  
Sarah A. Goodbrand ◽  
Douglas Lamont ◽  
Michael A. Ferguson ◽  
Robert J. Steele
Keyword(s):  
Colorectal Cancer ◽  
Quantitative Proteomics ◽  
Biomarker Discovery ◽  
Cancer Biomarker

Proteomic Profiling for Colorectal Cancer Biomarker Discovery

2018 ◽  
pp. 241-269 ◽  
Author(s):  
Paula Álvarez-Chaver ◽  
Loretta De Chiara ◽  
Vicenta Soledad Martínez-Zorzano
Keyword(s):  
Colorectal Cancer ◽  
Biomarker Discovery ◽  
Cancer Biomarker ◽  
Proteomic Profiling

Colorectal cancer biomarker discovery and validation using LC-MS/MS-based proteomics in blood: truth or dare?

2014 ◽  
Vol 11 (4) ◽  
pp. 449-463 ◽  
Author(s):  
Ank Reumer ◽  
Evelyne Maes ◽  
Inge Mertens ◽  
William CS Cho ◽  
Bart Landuyt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Biomarker Discovery ◽  
Cancer Biomarker

scholarly journals Identification of Novel Mutations in Colorectal Cancer Patients Using AmpliSeq Comprehensive Cancer Panel

2021 ◽  
Vol 11 (6) ◽  
pp. 535
Author(s):  
Bader Almuzzaini ◽  
Jahad Alghamdi ◽  
Alhanouf Alomani ◽  
Saleh AlGhamdi ◽  
Abdullah A. Alsharm ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Cancer Patients ◽  
Biomarker Discovery ◽  
Local Population ◽  
Network Analyses ◽  
Functional Perspective ◽  
Novel Variants ◽  
Colorectal Cancer Patients ◽  
Cancer Panel

Biomarker discovery would be an important tool in advancing and utilizing the concept of precision and personalized medicine in the clinic. Discovery of novel variants in local population provides confident targets for developing biomarkers for personalized medicine. We identified the need to generate high-quality sequencing data from local colorectal cancer patients and understand the pattern of occurrence of variants. In this report, we used archived samples from Saudi Arabia and used the AmpliSeq comprehensive cancer panel to identify novel somatic variants. We report a comprehensive analysis of next-generation sequencing results with a coverage of >300X. We identified 466 novel variants which were previously unreported in COSMIC and ICGC databases. We analyzed the genes associated with these variants in terms of their frequency of occurrence, probable pathogenicity, and clinicopathological features. Among pathogenic somatic variants, 174 were identified for the first time in the large intestine. APC, RET, and EGFR genes were most frequently mutated. A higher number of variants were identified in the left colon. Occurrence of variants in ERBB2 was significantly correlated with those of EGFR and ATR genes. Network analyses of the identified genes provide functional perspective of the identified genes and suggest affected pathways and probable biomarker candidates. This report lays the ground work for biomarker discovery and identification of driver gene mutations in local population.

scholarly journals Fucosylated haptoglobin is a novel type of cancer biomarker linked to the prognosis after an operation in colorectal cancer

Cancer ◽  
2011 ◽  
Vol 118 (12) ◽  
pp. 3036-3043 ◽  
Author(s):  
Yuri Takeda ◽  
Shinichiro Shinzaki ◽  
Kumiko Okudo ◽  
Kenta Moriwaki ◽  
Kohei Murata ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Biomarker ◽  
Fucosylated Haptoglobin

SA1 and Colorectal Cancer: Biomarker for Obesity-Driven CRC Carcinogenesis

2017 ◽  
Vol 152 (5) ◽  
pp. S1025
Author(s):  
Mart DeLa Cruz ◽  
Navneet Momi ◽  
Somenath Datta ◽  
Sanjib Chowdhury ◽  
Hemant K. Roy
Keyword(s):  
Colorectal Cancer ◽  
Cancer Biomarker
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