scholarly journals Fucosylated haptoglobin is a novel type of cancer biomarker linked to the prognosis after an operation in colorectal cancer

Cancer ◽  
2011 ◽  
Vol 118 (12) ◽  
pp. 3036-3043 ◽  
Author(s):  
Yuri Takeda ◽  
Shinichiro Shinzaki ◽  
Kumiko Okudo ◽  
Kenta Moriwaki ◽  
Kohei Murata ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Biomarker ◽  
Fucosylated Haptoglobin

SA1 and Colorectal Cancer: Biomarker for Obesity-Driven CRC Carcinogenesis

2017 ◽  
Vol 152 (5) ◽  
pp. S1025
Author(s):  
Mart DeLa Cruz ◽  
Navneet Momi ◽  
Somenath Datta ◽  
Sanjib Chowdhury ◽  
Hemant K. Roy
Keyword(s):  
Colorectal Cancer ◽  
Cancer Biomarker

scholarly journals EGFL6 Promotes Colorectal Cancer Cell Growth and Mobility and the Anti-cancer Property of Anti-EGFL6 Antibody

2020 ◽  
Author(s):  
Ting-Yi Sung ◽  
Han-Li Huang ◽  
Chun-Chun Cheng ◽  
Fu-Ling Chang ◽  
Po-Li Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cell ◽  
Animal Experiments ◽  
Patient Characteristics ◽  
Cancer Biomarker ◽  
Blue Staining ◽  
Migration And Invasion ◽  
Metal Stents ◽  
Αvβ3 Integrin ◽  
Phage Display Technology

Abstract BackgroundA reliable cancer biomarker will be critical for advanced colorectal cancer (CRC) therapeutic approaches since current treatments are limited to certain patient characteristics, such as age, sex, comorbidities and patients received self-expandable metal stents implantations. The association of epidermal growth factor-like domain 6 (EGFL6) with cancer development has been reported. Here, we focused on the role of EGFL6 in CRC progression and its clinical relevance. MethodsAn anti-EGFL6 antibody was generated by phage display technology to investigate the potential therapeutic efficacy in CRC. Methylene blue staining was applied to investigate the EGFL6 expression in CRC patients and animal tissue. Protein and DNA level of EGFL6 expression as well as related pathway investigation were determined by western blot and quantitative real time PCR. Silence EGFL6 by siRNA transfection, transwell migration and invasion assay were performed to verify EGFL6 function. Student t test, Kruskal-Wallis test and multiple comparisons were used to statistical analysis results. ResultsSignificant EGFL6 expression was found in colon tissues from patients and spontaneous tumorigenesis mouse but not in normal tissue. Furthermore, we found EGFL6 could enhance cancer cell migration, invasion and proliferation in CRC via up-regulating ERK/ AKT pathway, as well as reducing ADAMTS1 and Snail expression. We also found EGFL6 regulates cell abilities through EGFR/αvβ3 integrin receptors. By conducting animal experiments, our anti-EGFL6 antibody, EGFL6-E5-IgG, showed tumor inhibition and anti-metastasis ability. Furthermore, no impact on angiogenesis and wound healing by using EGFL6-E5-IgG were observed. ConclusionsWe demonstrated that EGFL6 plays a role in CRC tumorigenesis and tumor progression, indicating that EGFL6 is a potential cancer biomarker and therapeutic target worth further investigation.

W1897 Colorectal Cancer Biomarker Discovery Using Quantitative Proteomics

2009 ◽  
Vol 136 (5) ◽  
pp. A-749
Author(s):  
Sarah A. Goodbrand ◽  
Douglas Lamont ◽  
Michael A. Ferguson ◽  
Robert J. Steele
Keyword(s):  
Colorectal Cancer ◽  
Quantitative Proteomics ◽  
Biomarker Discovery ◽  
Cancer Biomarker

Proteomic Profiling for Colorectal Cancer Biomarker Discovery

2018 ◽  
pp. 241-269 ◽  
Author(s):  
Paula Álvarez-Chaver ◽  
Loretta De Chiara ◽  
Vicenta Soledad Martínez-Zorzano
Keyword(s):  
Colorectal Cancer ◽  
Biomarker Discovery ◽  
Cancer Biomarker ◽  
Proteomic Profiling

scholarly journals NAP1L1: A Novel Human Colorectal Cancer Biomarker Derived From Animal Models of Apc Inactivation

2020 ◽  
Vol 10 ◽  
Author(s):  
Cleberson J. S. Queiroz ◽  
Fei Song ◽  
Karen R. Reed ◽  
Nadeem Al-Khafaji ◽  
Alan R. Clarke ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Animal Models ◽  
Cancer Biomarker ◽  
Human Colorectal Cancer

scholarly journals Quantitation of putative colorectal cancer biomarker candidates in serum extracellular vesicles by targeted proteomics

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Takashi Shiromizu ◽  
Hideaki Kume ◽  
Mimiko Ishida ◽  
Jun Adachi ◽  
Masayuki Kano ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Extracellular Vesicles ◽  
Cancer Biomarker ◽  
Targeted Proteomics

scholarly journals Plasma Glycoprotein Profiling for Colorectal Cancer Biomarker Identification by Lectin Glycoarray and Lectin Blot

2008 ◽  
Vol 7 (4) ◽  
pp. 1693-1703 ◽  
Author(s):  
Yinghua Qiu ◽  
Tasneem H. Patwa ◽  
Li Xu ◽  
Kerby Shedden ◽  
David E. Misek ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Biomarker ◽  
Biomarker Identification ◽  
Lectin Blot ◽  
Plasma Glycoprotein
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