Increased Coverage in the Transmembrane Domain with Activated-Ion Electron Capture Dissociation for Top-Down Fourier-Transform Mass Spectrometry of Integral Membrane Proteins

2007 ◽  
Vol 6 (6) ◽  
pp. 2205-2210 ◽  
Author(s):  
Vlad Zabrouskov ◽  
Julian P. Whitelegge
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Membrane Proteins ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Fourier Transform Mass Spectrometry ◽  
Transmembrane Domain ◽  
Integral Membrane Proteins ◽  
Top Down

Advantages of External Accumulation for Electron Capture Dissociation in Fourier Transform Mass Spectrometry

2001 ◽  
Vol 73 (13) ◽  
pp. 2998-3005 ◽  
Author(s):  
Kim F. Haselmann ◽  
Bogdan A. Budnik ◽  
Jesper V. Olsen ◽  
Michael L. Nielsen ◽  
Celso A. Reis ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fourier Transform ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Fourier Transform Mass Spectrometry

scholarly journals Electron capture dissociation and drift tube ion mobility-mass spectrometry coupled with site directed mutations provide insights into the conformational diversity of a metamorphic protein

2015 ◽  
Vol 17 (16) ◽  
pp. 10538-10550 ◽  
Author(s):  
Sophie R. Harvey ◽  
Massimiliano Porrini ◽  
Robert C. Tyler ◽  
Cait E. MacPhee ◽  
Brian F. Volkman ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electron Capture ◽  
Electron Capture Dissociation ◽  
Ion Mobility ◽  
Drift Tube ◽  
Ion Mobility Mass Spectrometry ◽  
Top Down ◽  
Conformational Diversity ◽  
Metamorphic Protein

Ion mobility mass spectrometry can be combined with data from top-down sequencing to discern adopted conformations of proteins in the absence of solvent.

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