Model-Based Solvent Selection during Conceptual Process Design of a New Drug Manufacturing Process

2009 ◽  
Vol 13 (4) ◽  
pp. 690-697 ◽  
Author(s):  
Daniel Hsieh ◽  
Alexander J. Marchut ◽  
Chenkou Wei ◽  
Bin Zheng ◽  
Steve S. Y. Wang ◽  
...  
2013 ◽  
Vol 85 (9) ◽  
pp. 1358-1358
Author(s):  
A. B. de Haan ◽  
G. W. Meindersma ◽  
E. Quijada-Maldonado ◽  
M. T. G. Jongmans ◽  
J. P. Gutiérrez Hernandez ◽  
...  

2013 ◽  
Vol 397-400 ◽  
pp. 57-61
Author(s):  
Dong Jie Zhong

Green manufacturing process is a key segment to guarantee green degree of products manufacturing course. In this paper, a kind of design system is presented by analyzing the function demand of the design system for green manufacturing process and then the modules which constituent the design system are analyzed in detail. Moreover, according to the design principle and the estimate indexes of green manufacturing process, the operation flow of the design system is introduced.


Author(s):  
Jesse D. Peplinski ◽  
Janet K. Allen ◽  
Farrokh Mistree

Abstract How can the manufacturability of different product design alternatives be evaluated efficiently during the early stages of concept exploration? The benefits of such integrated product and manufacturing process design are widely recognized and include faster time to market, reduced development costs and production costs, and increased product quality. To reap these benefits fully, however, one must examine product/process trade-offs and cost/schedule/performance trade-offs in the early stages of design. Evaluating production cost and lead time requires detailed simulation or other analysis packages which 1) would be computationally expensive to run for every alternative, and 2) require detailed information that may or may not be available in these early design stages. Our approach is to generate response surfaces that serve as approximations to the analyses packages and use these approximations to identify robust regions of the design space for further exploration. In this paper we present a method for robust product and process exploration and illustrate this method using a simplified example of a machining center processing a single component. We close by discussing the implications of this work for manufacturing outsourcing, designing robust supplier chains, and ultimately designing the manufacturing enterprise itself.


Author(s):  
George Chryssolouris ◽  
Dimitris Mavrikios ◽  
Dimitris Fragos ◽  
Vassiliki Karabatsou

2018 ◽  
Vol 26 ◽  
pp. 1388-1397 ◽  
Author(s):  
Brian K. Paul ◽  
Patrick McNeff

2020 ◽  
Vol 8 ◽  
Author(s):  
Bianca Consorti Bussamra ◽  
Paulus Meerman ◽  
Vidhvath Viswanathan ◽  
Solange I. Mussatto ◽  
Aline Carvalho da Costa ◽  
...  

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