Process Intensification of the Suzuki–Miyaura Reaction over Sol–Gel Entrapped Catalyst SiliaCat DPP-Pd Under Conditions of Continuous Flow

2014 ◽  
Vol 18 (11) ◽  
pp. 1550-1555 ◽  
Author(s):  
Valerica Pandarus ◽  
Geneviève Gingras ◽  
François Béland ◽  
Rosaria Ciriminna ◽  
Mario Pagliaro
Keyword(s):  
Continuous Flow ◽  
Sol Gel ◽  
Process Intensification

scholarly journals Microwave-Assisted Vacuum Synthesis of TiO2 Nanocrystalline Powders in One-Pot, One-Step Procedure

Nanomaterials ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 149
Author(s):  
Enrico Paradisi ◽  
Roberto Rosa ◽  
Giovanni Baldi ◽  
Valentina Dami ◽  
Andrea Cioni ◽  
...  
Keyword(s):  
Photocatalytic Activity ◽  
Sol Gel ◽  
Reaction Medium ◽  
Process Intensification ◽  
Nanocrystalline Powders ◽  
Fast Heating ◽  
One Pot ◽  
Nanoparticle Suspension ◽  
Step Procedure ◽  
One Step

A new method for fast and simple synthesis of crystalline TiO2 nanoparticles with photocatalytic activity was developed by carrying out a classic sol–gel reaction directly under vacuum. The use of microwaves for fast heating of the reaction medium further reduces synthesis times. When the solvent is completely removed by vacuum, the product is obtained in the form of a powder that can be easily redispersed in water to yield a stable nanoparticle suspension, exhibiting a comparable photocatalytic activity with respect to a commercial product. The present methodology can, therefore, be considered a process intensification procedure for the production of nanotitania.

Process Intensification of Continuous Flow Synthesis of Tryptophol

2018 ◽  
Vol 57 (8) ◽  
pp. 2787-2796 ◽  
Author(s):  
Yogeshwar R. Dubhashe ◽  
Vishal M. Sawant ◽  
Vilas G. Gaikar
Keyword(s):  
Continuous Flow ◽  
Process Intensification ◽  
Flow Synthesis

scholarly journals Immobilized Whole-Cell Transaminase Biocatalysts for Continuous-Flow Kinetic Resolution of Amines

Catalysts ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 438 ◽  
Author(s):  
Zsófia Molnár ◽  
Emese Farkas ◽  
Ágnes Lakó ◽  
Balázs Erdélyi ◽  
Wolfgang Kroutil ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Kinetic Resolution ◽  
Sol Gel ◽  
Chiral Amines ◽  
Flow Mode ◽  
Immobilized Cell ◽  
Hollow Silica ◽  
E Coli ◽  
Sol Gel Process ◽  
Racemic Amines

Immobilization of transaminases creates promising biocatalysts for production of chiral amines in batch or continuous-flow mode reactions. E. coli cells containing overexpressed transaminases of various selectivities and hollow silica microspheres as supporting agent were immobilized by an improved sol-gel process to produce immobilized transaminase biocatalysts with suitable stability and mechanical properties for continuous-flow applications. The immobilized cell-based transaminase biocatalyst proved to be durable and easy-to-use in kinetic resolution of four racemic amines 1a–d. The batch and continuous-flow mode kinetic resolutions with transaminase biocatalyst of opposite stereopreference provided access to both enantiomers of the corresponding amines. By using the most suitable immobilized transaminase biocatalysts, this study describes the first transaminase-based approach for the production of both pure enantiomers of 1-(3,4-dimethoxyphenyl)ethan-1-amine 1d.

On the Fischer Indole Synthesis of 7-Ethyltryptophol—Mechanistic and Process Intensification Studies under Continuous Flow Conditions

2013 ◽  
Vol 17 (2) ◽  
pp. 294-302 ◽  
Author(s):  
Bernhard Gutmann ◽  
Michael Gottsponer ◽  
Petteri Elsner ◽  
David Cantillo ◽  
Dominique M. Roberge ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Process Intensification ◽  
Flow Conditions ◽  
Fischer Indole Synthesis ◽  
Indole Synthesis

Sol–Gel Catalysts as an Efficient Tool for the Kumada-Corriu Reaction in Continuous Flow

2013 ◽  
Vol 5 (5) ◽  
pp. 475-483 ◽  
Author(s):  
Lucia Marra ◽  
Vincenzo Fusillo ◽  
Charlotte Wiles ◽  
Alessandra Zizzari ◽  
Paul Watts ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Sol Gel ◽  
Efficient Tool

scholarly journals A sustainable approach to empower the bio-based future: upgrading of biomass via process intensification

2017 ◽  
Vol 19 (7) ◽  
pp. 1624-1627 ◽  
Author(s):  
Kidus Tadele ◽  
Sanny Verma ◽  
Michael A. Gonzalez ◽  
Rajender S. Varma
Keyword(s):  
Continuous Flow ◽  
Process Intensification ◽  
Environmentally Benign

An environmentally benign continuous flow intensified process has been developed that enables upgrading of biomass into biofuels, solvents and pharmaceutical feedstocks using a bimetallic AgPd@g-C3N4 catalyst.

Process intensification for tertiary amine catalyzed glycerol carbonate production: translating microwave irradiation to a continuous-flow process

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 20945-20950 ◽  
Author(s):  
Daniel O. Nogueira ◽  
Stefânia P. de Souza ◽  
Raquel A. C. Leão ◽  
Leandro S. M. Miranda ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Microwave Irradiation ◽  
Physical Properties ◽  
Tertiary Amine ◽  
Continuous Flow ◽  
Water Solubility ◽  
Process Intensification ◽  
Glycerol Carbonate ◽  
Flow Process ◽  
Carbonate Production ◽  
Continuous Flow Process

Different products of interest can be produced from glycerol and glycerol carbonate (GC) has received much attention in recent years because of its physical properties, nontoxicity and water solubility.

Continuous Flow Mode Biocatalytic Transamination Using Macrocellular Silica Monoliths: Optimizing Support Functionalisation and Enzyme Grafting

2019 ◽  
Author(s):  
Ludivine van den Biggelaar ◽  
Patrice Soumillion ◽  
Damien Debecker
Keyword(s):  
Enzyme Immobilization ◽  
Continuous Flow ◽  
Sol Gel ◽  
Fold Increase ◽  
Covalent Attachment ◽  
Flow Mode ◽  
Active Materials ◽  
Silica Monoliths ◽  
Transamination Reaction ◽  
Reported Data

<div>Transaminases are immobilized onto macrocellular silica monoliths and used for carrying a continuous flow mode transamination reaction. Monoliths were prepared via an emulsion-templated sol-gel method and functionalized by amino-moieties (APTES) in order to covalently immobilize the enzymes, using glutaraldehyde as a cross-linking agent. In order to obtain higher performance and improved reproducibility, we investigate the key parameters of APTES functionalization and of enzyme grafting. Four functionalization protocols were studied. It is shown that controlling the moisture levels in monolith and in the functionalisation solution led to a 3-fold increase in activity as compared to the previously reported data, and greatly improved the reproducibility. Additionally, we report a strong beneficial effect of running the enzyme immobilization at room temperature instead of 4°C, further enhancing the obtained activity. Finally, the popular method which consists in stabilizing the covalent attachment of the enzyme by reducing the imine bonds formed between the enzyme and the functionalized surface was investigated. We highlight a strong enzyme deactivation caused by cyanoborohydride, making this strategy irrelevant in this case. All in all, the improvements presented here for enzyme immobilization in macrocellular silica monoliths, lead to the preparation of more active materials for continuous flow mode biocatalysis.<br></div>

Sign in / Sign up

Export Citation Format

Share Document