Development of a Scalable Synthesis of Oxadiazole Based S1P1 Receptor Agonists

2013 ◽  
Vol 17 (4) ◽  
pp. 666-671 ◽  
Author(s):  
Kirill Lukin ◽  
Vimal Kishore ◽  
Thomas Gordon
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Scalable Synthesis

Scalable Synthesis and Isolation of the Four Stereoisomers of Methyl 1-Amino-3-(4-bromophenyl)cyclopentanecarboxylate, Useful Intermediates for the Synthesis of S1P1 Receptor Agonists

2009 ◽  
Vol 74 (13) ◽  
pp. 4886-4889 ◽  
Author(s):  
Grier A. Wallace ◽  
Thomas D. Gordon ◽  
Martin E. Hayes ◽  
Donald B. Konopacki ◽  
Shannon R. Fix-Stenzel ◽  
...  
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Scalable Synthesis

Indole-propionic acid derivatives as potent, S1P3-sparing and EAE efficacious sphingosine-1-phosphate 1 (S1P1) receptor agonists

2012 ◽  
Vol 22 (8) ◽  
pp. 2794-2797 ◽  
Author(s):  
Qinghua Meng ◽  
Baowei Zhao ◽  
Qiongfeng Xu ◽  
Xuesong Xu ◽  
Guanghui Deng ◽  
...  
Keyword(s):  
Propionic Acid ◽  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Sphingosine 1 Phosphate

Novel S1P1 receptor agonists – Part 5: From amino-to alkoxy-pyridines

2016 ◽  
Vol 115 ◽  
pp. 326-341 ◽  
Author(s):  
Martin H. Bolli ◽  
Cyrille Lescop ◽  
Magdalena Birker ◽  
Ruben de Kanter ◽  
Patrick Hess ◽  
...  
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor

Novel S1P1 Receptor Agonists - Part 2: From Bicyclo[3.1.0]hexane-Fused Thiophenes to Isobutyl Substituted Thiophenes

2013 ◽  
Vol 57 (1) ◽  
pp. 78-97 ◽  
Author(s):  
Martin H. Bolli ◽  
Jörg Velker ◽  
Claus Müller ◽  
Boris Mathys ◽  
Magdalena Birker ◽  
...  
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Fused Thiophenes

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists

2005 ◽  
Vol 15 (15) ◽  
pp. 3568-3572 ◽  
Author(s):  
Jeremy J. Clemens ◽  
Michael D. Davis ◽  
Kevin R. Lynch ◽  
Timothy L. Macdonald
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Sphingosine 1 Phosphate

Pyrazole derived from (+)-3-carene; a novel potent, selective scaffold for sphingosine-1-phosphate (S1P1) receptor agonists

2010 ◽  
Vol 20 (1) ◽  
pp. 35-37 ◽  
Author(s):  
Frédéric J. Zécri ◽  
Rainer Albert ◽  
Gregory Landrum ◽  
Klaus Hinterding ◽  
Nigel G. Cooke ◽  
...  
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Sphingosine 1 Phosphate

scholarly journals Benzofuran Derivatives as Potent, Orally Active S1P1 Receptor Agonists: A Preclinical Lead Molecule for MS

2010 ◽  
Vol 2 (2) ◽  
pp. 97-101 ◽  
Author(s):  
Ashis K. Saha ◽  
Xiang Yu ◽  
Jian Lin ◽  
Mercedes Lobera ◽  
Anurag Sharadendu ◽  
...  
Keyword(s):  
Receptor Agonists ◽  
S1p1 Receptor ◽  
Orally Active

scholarly journals 3D-QSAR Studies on Thiazolidin-4-one S1P1 Receptor Agonists by CoMFA and CoMSIA

2011 ◽  
Vol 12 (10) ◽  
pp. 6502-6516 ◽  
Author(s):  
Chuiwen Qian ◽  
Junxia Zheng ◽  
Gaokeng Xiao ◽  
Jialiang Guo ◽  
Zhaoqi Yang ◽  
...  
Keyword(s):  
3D Qsar ◽  
Qsar Studies ◽  
Receptor Agonists ◽  
S1p1 Receptor

Recent progress in the development of selective S1P1 receptor agonists for the treatment of inflammatory and autoimmune disorders

2008 ◽  
Vol 18 (10) ◽  
pp. 1141-1159 ◽  
Author(s):  
Daniel J Buzard ◽  
Jayant Thatte ◽  
Michael Lerner ◽  
Jeffrey Edwards ◽  
Robert M Jones
Keyword(s):  
Recent Progress ◽  
Autoimmune Disorders ◽  
Receptor Agonists ◽  
S1p1 Receptor
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