Efficient Purification of an Active Pharmaceutical Ingredient via Cocrystallization: From Thermodynamics to Scale-Up

2012 ◽  
Vol 17 (3) ◽  
pp. 505-511 ◽  
Author(s):  
Pascal Billot ◽  
Patrik Hosek ◽  
Marc-Antoine Perrin
Keyword(s):  
Scale Up ◽  
Active Pharmaceutical Ingredient

Development and Scale-Up of a Continuous Reaction for Production of an Active Pharmaceutical Ingredient Intermediate

2018 ◽  
Vol 22 (9) ◽  
pp. 1208-1213 ◽  
Author(s):  
Jonathan P. McMullen ◽  
Christopher H. Marton ◽  
Benjamin D. Sherry ◽  
Glenn Spencer ◽  
Joseph Kukura ◽  
...  
Keyword(s):  
Scale Up ◽  
Active Pharmaceutical Ingredient ◽  
Continuous Reaction

Scale-up of agitated drying: Effect of shear stress and hydrostatic pressure on active pharmaceutical ingredient powder properties

AIChE Journal ◽  
2014 ◽  
Vol 61 (2) ◽  
pp. 407-418 ◽  
Author(s):  
Brenda Remy ◽  
Weston Kightlinger ◽  
Eric M. Saurer ◽  
Nathan Domagalski ◽  
Benjamin J. Glasser
Keyword(s):  
Shear Stress ◽  
Hydrostatic Pressure ◽  
Scale Up ◽  
Active Pharmaceutical Ingredient ◽  
Powder Properties

NiAl precipitation in Fe-12w/o Cr-5w/o Ni-4w/o Al

1983 ◽  
Vol 41 ◽  
pp. 202-203
Author(s):  
L.E. Murr ◽  
J.S. Dunning ◽  
S. Shankar
Keyword(s):  
Solid Solution ◽  
Stainless Steel ◽  
Stainless Steels ◽  
Alloy Composition ◽  
Chromium Content ◽  
Scale Up ◽  
Optical Metallography ◽  
Property Evaluation ◽  
310 Stainless Steel ◽  
Microstructural Studies

Aluminum additions to conventional 18Cr-8Ni austenitic stainless steel compositions impart excellent resistance to high sulfur environments. However, problems are typically encountered with aluminum additions above about 1% due to embrittlement caused by aluminum in solid solution and the precipitation of NiAl. Consequently, little use has been made of aluminum alloy additions to stainless steels for use in sulfur or H2S environments in the chemical industry, energy conversion or generation, and mineral processing, for example.A research program at the Albany Research Center has concentrated on the development of a wrought alloy composition with as low a chromium content as possible, with the idea of developing a low-chromium substitute for 310 stainless steel (25Cr-20Ni) which is often used in high-sulfur environments. On the basis of workability and microstructural studies involving optical metallography on 100g button ingots soaked at 700°C and air-cooled, a low-alloy composition Fe-12Cr-5Ni-4Al (in wt %) was selected for scale up and property evaluation.

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