First Scale-Up to Production Scale of a Ring Closing Metathesis Reaction Forming a 15-Membered Macrocycle as a Precursor of an Active Pharmaceutical Ingredient

2005 ◽  
Vol 9 (4) ◽  
pp. 513-515 ◽  
Author(s):  
Thomas Nicola ◽  
Michael Brenner ◽  
Kai Donsbach ◽  
Paul Kreye
Keyword(s):  
Scale Up ◽  
Active Pharmaceutical Ingredient ◽  
Metathesis Reaction ◽  
Ring Closing Metathesis ◽  
Production Scale

A Double Ring Closing Metathesis Reaction in the Rapid, Enantioselective Synthesis of NK-1 Receptor Antagonists

2001 ◽  
Vol 3 (5) ◽  
pp. 671-674 ◽  
Author(s):  
Debra J. Wallace ◽  
Jonathan M. Goodman ◽  
Derek J. Kennedy ◽  
Antony J. Davies ◽  
Cameron J. Cowden ◽  
...  
Keyword(s):  
Enantioselective Synthesis ◽  
Metathesis Reaction ◽  
Receptor Antagonists ◽  
Ring Closing Metathesis ◽  
Double Ring

Synthesis of New Tricyclic Spirobispidines via Ring Closing Metathesis Reaction

Heterocycles ◽  
2007 ◽  
Vol 71 (11) ◽  
pp. 2331 ◽  
Author(s):  
Christian Hametner ◽  
Daniel Dangl ◽  
Kurt Mereiter ◽  
Martina Marchetti ◽  
Johannes Fröhlich
Keyword(s):  
Metathesis Reaction ◽  
Ring Closing Metathesis

scholarly journals Synthesis of fluorinated δ-lactams via cycloisomerization of gem-difluoropropargyl amides

2010 ◽  
Vol 6 ◽  
Author(s):  
Satoru Arimitsu ◽  
Gerald B Hammond
Keyword(s):  
Building Blocks ◽  
Alder Reaction ◽  
Diels Alder ◽  
Tandem Reaction ◽  
Enyne Metathesis ◽  
Metathesis Reaction ◽  
Ring Closing Metathesis ◽  
Diels Alder Reaction

gem-Difluoro-1,7-enyne amides are suitable building blocks for the synthesis of difluorodihydropyridinones via a ring-closing metathesis reaction, and of 4,4-difluoro-3-oxoisoquinolines through a ring-closing metathesis–enyne metathesis tandem reaction. These products, in turn, undergo a Diels–Alder reaction to yield heterotricyclic systems in moderate to good yields.

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