Redox-Active N-Heterocyclic Carbenes: Design, Synthesis, and Evaluation of Their Electronic Properties

2009 ◽  
Vol 28 (23) ◽  
pp. 6695-6706 ◽  
Author(s):  
Evelyn L. Rosen ◽  
C. Daniel Varnado ◽  
Andrew G. Tennyson ◽  
Dimitri M. Khramov ◽  
Justin W. Kamplain ◽  
...  
Keyword(s):  
Electronic Properties ◽  
Heterocyclic Carbenes ◽  
Design Synthesis ◽  
Redox Active

N-heterocyclic carbene-metal complexes as bio-organometallic antimicrobial and anticancer drugs, an update (2015–2020)

2020 ◽  
Vol 12 (24) ◽  
pp. 2239-2275
Author(s):  
Siddappa A Patil ◽  
Amy P Hoagland ◽  
Shivaputra A Patil ◽  
Alejandro Bugarin
Keyword(s):  
Metal Complexes ◽  
Biomedical Applications ◽  
Chemical Properties ◽  
Therapeutic Agents ◽  
Heterocyclic Carbenes ◽  
Design Synthesis ◽  
Drug Candidates ◽  
The Past ◽  
Simple Variation ◽  
Future Work

N-heterocyclic carbenes (NHCs) are organic compounds that typically mimic the chemical properties of phosphines. NHCs have made a significant impact on the field of coordination and organometallic chemistry because they are easy to prepare and handle and because of their versatility and stability. Importantly, the physicochemical properties of NHCs can be easily fine-tuned by simple variation of substituents on the nitrogen atoms. Over the past few years, various NHC–metal complexes have been extensively used as metal-based drug candidates and catalysts (homogeneous or heterogeneous) for various applications. To help assist future work with these compounds, this review provides a thorough review on the latest information involving some biomedical applications of NHC–metal complexes. Specifically, this article focuses on recent advances in the design, synthesis, characterization and biomedical applications (e.g., antimicrobial and anticancer activity) of various NHC–metal complexes (metal: silver, gold, palladium, rhodium, ruthenium, iridium and platinum) covering work published from 2015 to 2020. It is hoped that the promising discoveries to date will help accelerate studies on the encouraging potential of NHC–metal complexes as a class of effective therapeutic agents.

scholarly journals Stable Planar Six-π-Electron Six-Membered N-Heterocyclic Carbenes with Tunable Electronic Properties

2005 ◽  
Vol 127 (29) ◽  
pp. 10182-10183 ◽  
Author(s):  
Carsten Präsang ◽  
Bruno Donnadieu ◽  
Guy Bertrand
Keyword(s):  
Electronic Properties ◽  
Heterocyclic Carbenes

A stable open-shell redox active ditopic ligand

2016 ◽  
Vol 45 (13) ◽  
pp. 5460-5463 ◽  
Author(s):  
N. M. Bonanno ◽  
A. J. Lough ◽  
K. E. Prosser ◽  
C. J. Walsby ◽  
P. K. Poddutoori ◽  
...  
Keyword(s):  
Electronic Properties ◽  
Open Shell ◽  
Redox Active ◽  
Ditopic Ligand

Herein we describe the synthesis, structure and electronic properties of an unusual redox-active ditopic ligand with a stable open-shell configuration.

Chiral, Sterically Demanding N-Heterocyclic Carbenes Fused into a Heterobiaryl Skeleton: Design, Synthesis, and Structural Analysis

2015 ◽  
Vol 34 (7) ◽  
pp. 1328-1338 ◽  
Author(s):  
Manuela Espina ◽  
Ivan Rivilla ◽  
Ana Conde ◽  
M. Mar Díaz-Requejo ◽  
Pedro J. Pérez ◽  
...  
Keyword(s):  
Structural Analysis ◽  
Heterocyclic Carbenes ◽  
Design Synthesis ◽  
Sterically Demanding
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