Divalent Platinum Complexes of the Carbanion 2-C6F4AsPh2: Monodentate or Bidentate Coordination?

2013 ◽  
Vol 32 (24) ◽  
pp. 7451-7459 ◽  
Author(s):  
Nedaossadat Mirzadeh ◽  
Steven H. Privér ◽  
Martin A. Bennett ◽  
Jörg Wagler ◽  
Suresh K. Bhargava
Keyword(s):  
Platinum Complexes ◽  
Bidentate Coordination ◽  
Divalent Platinum

cis-Effect in divalent platinum complexes

1974 ◽  
Vol 23 (6) ◽  
pp. 1332-1333
Author(s):  
N. N. Zheligovskaya ◽  
S. V. Loginov ◽  
L. V. Popov ◽  
V. I. Spitsyn
Keyword(s):  
Platinum Complexes ◽  
Divalent Platinum

scholarly journals Tungsten–platinum μ-carbido and μ-methylidyne complexes

2019 ◽  
Vol 55 (82) ◽  
pp. 12400-12403 ◽  
Author(s):  
Benjamin J. Frogley ◽  
Anthony F. Hill
Keyword(s):  
Platinum Complexes ◽  
Divalent Platinum

The lithiocarbyne [W]CLi ([W] = W(CO)2(Tp*); Tp* = tris(dimethylpyrazolyl)borate) with divalent platinum complexes afford access to μ-carbido, μ-methylidyne and carbyne-based metallo-ligand complexes.

Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Nalidixic Acid ◽  
Copper Complexes ◽  
Biological Activities ◽  
Bidentate Coordination ◽  
Antibacterial And Antifungal Activities ◽  
Elemental Analyses ◽  
Oxadiazole Derivatives ◽  
Antibacterial And Antifungal ◽  
Derivatives Of ◽  
Substituted 1

A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxadiazole ring. The synthesized compounds were further evaluated with biological activities and compared with parent hydrazones. Copper complexes possess antibacterial and antifungal activities better than the oxadiazoles while they have better antioxidant activity then copper complexes. Parent hydrazones were better in all biological activities than synthesized oxadiazoles.

scholarly journals First Attempts of the Use of 195Pt NMR of Phenylbenzothiazole Complexes as Spectroscopic Technique for the Cancer Diagnosis

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3970 ◽  
Author(s):  
Bruna T. L. Pereira ◽  
Mateus A. Gonçalves ◽  
Daiana T. Mancini ◽  
Kamil Kuca ◽  
Teodorico C. Ramalho
Keyword(s):  
Cancer Treatment ◽  
Cancer Diagnosis ◽  
Density Functional ◽  
Chemical Shifts ◽  
Chloride Ion ◽  
Platinum Complexes ◽  
Dft Method ◽  
Ion Concentration ◽  
Implicit Solvent ◽  
Early Cancer Diagnosis

Platinum complexes have been studied for cancer treatment for several decades. Furthermore, another important platinum characteristic is related to its chemical shifts, in which some studies have shown that the 195Pt chemical shifts are very sensitive to the environment, coordination sphere, and oxidation state. Based on this relevant feature, Pt complexes can be proposed as potential probes for NMR spectroscopy, as the chemical shifts values will be different in different tissues (healthy and damaged) Therefore, in this paper, the main goal was to investigate the behavior of Pt chemical shifts in the different environments. Calculations were carried out in vacuum, implicit solvent, and inside the active site of P13K enzyme, which is related with breast cancer, using the density functional theory (DFT) method. Moreover, the investigation of platinum complexes with a selective moiety can contribute to early cancer diagnosis. Accordingly, the Pt complexes selected for this study presented a selective moiety, the 2-(4′aminophenyl)benzothiazole derivative. More specifically, two Pt complexes were used herein: One containing chlorine ligands and one containing water in place of chlorine. Some studies have shown that platinum complexes coordinated to chlorine atoms may suffer hydrolyses inside the cell due to the low chloride ion concentration. Thus, the same calculations were performed for both complexes. The results showed that both complexes presented different chemical shift values in the different proposed environments. Therefore, this paper shows that platinum complexes can be a potential probe in biological systems, and they should be studied not only for cancer treatment, but also for diagnosis.

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