Derivatization of Preformed Platinum N-Heterocyclic Carbene Complexes with Amino Acid and Peptide Ligands and Cytotoxic Activities toward Human Cancer Cells

2012 ◽  
Vol 31 (21) ◽  
pp. 7618-7621 ◽  
Author(s):  
Edith Chardon ◽  
Georges Dahm ◽  
Gilles Guichard ◽  
Stéphane Bellemin-Laponnaz
Keyword(s):  
Amino Acid ◽  
Cancer Cells ◽  
Human Cancer ◽  
Peptide Ligands ◽  
Cytotoxic Activities ◽  
Carbene Complexes ◽  
Human Cancer Cells

Rhodium(i) N-heterocyclic carbene complexes: synthesis and cytotoxic properties

2021 ◽  
Vol 45 (11) ◽  
pp. 5176-5183
Author(s):  
Ichraf Slimani ◽  
Serap Şahin-Bölükbaşı ◽  
Mustafa Ulu ◽  
Enes Evren ◽  
Nevin Gürbüz ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Mtt Assay ◽  
Incubation Time ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Carbene Complexes ◽  
Human Cancer Cells ◽  
Benzimidazolium Salts ◽  
Ht 29

A series of benzimidazolium salts and their [RhCl(NHC)(COD)] complexes were synthesized. All compounds were screened for in vitro cytotoxic activities against a panel of human cancer cells (HT-29 colon, Ishikawa endometrial, U-87 glioblastoma) using the MTT assay for 48 h incubation time.

scholarly journals Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

2021 ◽  
Vol 16 (2) ◽  
pp. 1934578X2199615
Author(s):  
Lucas Botelho Jerônimo ◽  
Jamile S. da Costa ◽  
Laine C. Pinto ◽  
Raquel C. Montenegro ◽  
William N. Setzer ◽  
...  
Keyword(s):  
Essential Oils ◽  
Cancer Cells ◽  
Antioxidant Activities ◽  
Human Cancer ◽  
Psidium Guajava ◽  
Cytotoxic Activities ◽  
Chemical Compositions ◽  
Main Compound ◽  
Human Cancer Cells ◽  
High Concentrations

This work analyzed the chemical compositions and evaluated the antioxidant and cytotoxic activities of essential oils (EO) of Eugenia patrisii (Epat), Eugenia stipitata (Esti), Myrcia splendens (Mspl), Myrcia sylvatica (Msyl), Psidium guajava (Pgua), and Psidium guineense (Pgui-1 and Pgui-2) from the Brazilian Amazon. Sesquiterpenoids were found in high concentrations in the oils of E. patrisii and M. splendens, which were rich in E-caryophyllene (32.0% and 45.8%); E. stipitata and M. sylvatica, which displayed germacrene D (11.8%) and germacrene B (24.5%); and P. guajava that showed epi-β-bisabolol (16.1%) as the main compound. However, P. guineense samples (Pgui-1 and Pgui-2) were rich in monoterpenoids such as limonene (Pgui-1: 30.2%; Pgui-2 30.4%) and α-pinene (Pgui-1: 22.5%; Pgui-2: 17.7%). The samples showed a weak and moderate antioxidant activities in the DPPH assay, displaying inhibition rates from 11.5% to 38.6% (at 10 mg/mL). All samples were cytotoxic against human cancer cells by the MTT method. Epat oil showed higher activity against melanoma (SKMEL-19, IC505.8 µg/mL), gastric (AGP01, IC503.2 µg/mL), and colon (HCT116, IC506.7 µg/mL). Meanwhile, the samples Pgua and Pgui were more active against breast cancer cells (MCF7, IC5012.4 µg/mL and 11.6 µg/mL, respectively).

Synthesis, antimicrobial and cytotoxic activities, and structure–activity relationships of gypsogenin derivatives against human cancer cells

2014 ◽  
Vol 82 ◽  
pp. 565-573 ◽  
Author(s):  
Safiye Emirdağ-Öztürk ◽  
Tamer Karayıldırım ◽  
Aysun Çapcı-Karagöz ◽  
Özgen Alankuş-Çalışkan ◽  
Ali Özmen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Structure Activity Relationships ◽  
Human Cancer Cells ◽  
Structure Activity

scholarly journals Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone–Amino Acid Derivatives

Molecules ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 1199 ◽  
Author(s):  
Jaime Valderrama ◽  
Virginia Delgado ◽  
Sandra Sepúlveda ◽  
Julio Benites ◽  
Cristina Theoduloz ◽  
...  
Keyword(s):  
Amino Acid ◽  
Cytotoxic Activity ◽  
Cancer Cells ◽  
Human Cancer ◽  
Amino Acid Derivatives ◽  
Human Cancer Cells

ChemInform Abstract: Sesquiterpenes from Rhizomes of Cyperus rotundus with Cytotoxic Activities on Human Cancer Cells in vitro.

ChemInform ◽  
2016 ◽  
Vol 47 (8) ◽  
pp. no-no ◽  
Author(s):  
Byeol Ryu ◽  
Hye Mi Kim ◽  
Jae-Seung Lee ◽  
Yoon Jin Cho ◽  
Myung Sook Oh ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cyperus Rotundus ◽  
Cytotoxic Activities ◽  
Human Cancer Cells

Enniatin Exerts p53-Dependent Cytostatic and p53-Independent Cytotoxic Activities against Human Cancer Cells

2007 ◽  
Vol 20 (3) ◽  
pp. 465-473 ◽  
Author(s):  
Rita Dornetshuber ◽  
Petra Heffeter ◽  
Majid-Reza Kamyar ◽  
Thomas Peterbauer ◽  
Walter Berger ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Cytotoxic Activities ◽  
Human Cancer Cells
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