Facile One-Pot Synthesis of 4,5-Disubstituted 1,2,3-(NH)-Triazoles through Sonogashira Coupling/1,3-Dipolar Cycloaddition of Acid Chlorides, Terminal Acetylenes, and Sodium Azide

2009 ◽  
Vol 11 (14) ◽  
pp. 3024-3027 ◽  
Author(s):  
Jihui Li ◽  
Dong Wang ◽  
Yuanqing Zhang ◽  
Jiting Li ◽  
Baohua Chen
Keyword(s):  
Sodium Azide ◽  
Dipolar Cycloaddition ◽  
Sonogashira Coupling ◽  
Acid Chlorides ◽  
One Pot ◽  
One Pot Synthesis ◽  
Terminal Acetylenes

scholarly journals One-pot synthesis of 3-substituted-4H-[1,2,3] triazolo[5,1-c][1,4]oxazin-6(7H)-ones from propargyl alcohols, chloroacetyl chloride, and sodium azide

2020 ◽  
pp. 174751982094835
Author(s):  
Xiao-Lan Zhang ◽  
Mei-Hong Wei ◽  
Jun-Min Chen ◽  
Shou-Ri Sheng ◽  
Xiao-Ling Liu
Keyword(s):  
Sodium Azide ◽  
High Efficiency ◽  
Dipolar Cycloaddition ◽  
Chloroacetyl Chloride ◽  
One Pot ◽  
Product Yields ◽  
Simple Operation ◽  
One Pot Synthesis ◽  
Propargyl Alcohols

An efficient, one-pot synthesis of 3-substituted-4 H-[1,2,3]triazolo[5,1- c][1,4]oxazin-6(7 H)-ones is developed via sequential esterification, substitution, and 1,3-dipolar cycloaddition processes of various propargyl alcohols, chloroacetyl chloride, and sodium azide. This method provides a variety of novel 1,2,3-triazole-fused oxazinones and has several advantages including simple operation, high efficiency, and good-to-excellent product yields (80%–95%) without the need to isolate the ester and azide intermediates.

Hypervalent-Iodine Mediated One-Pot Synthesis of Isoxazolines and Isoxazoles bearing Difluoromethyl Phosphonate Moiety

2021 ◽  
Author(s):  
Romana Pajkert ◽  
Henryk Koroniak ◽  
Pawel Kafarski ◽  
Gerd Volker Roeschenthaler
Keyword(s):  
Nitrile Oxide ◽  
Dipolar Cycloaddition ◽  
Hypervalent Iodine ◽  
One Pot ◽  
One Pot Synthesis

A one-pot, regioselective 1,3-dipolar cycloaddition of in situ generated (diethoxyphosphoryl)difluoromethyl nitrile oxide toward selected alkenes and alkynes is reported. This protocol enables facile access to 3,5-disubstituted isoxazolines and isoxazoles bearing...

One-Pot Synthesis of Naphtho[1′,2′:4,5]imidazo[1,2-a ]pyridin-5-yl(aryl)methanones through Sequential Sonogashira Coupling/Alkyne-Carbonyl Metathesis

2017 ◽  
Vol 2017 (27) ◽  
pp. 4026-4034 ◽  
Author(s):  
Mirza Feroz Baig ◽  
Siddiq Pasha Shaik ◽  
Namballa Hari Krishna ◽  
Neeraj Kumar Chouhan ◽  
Abdullah Alarifi ◽  
...  
Keyword(s):  
Sonogashira Coupling ◽  
One Pot ◽  
One Pot Synthesis

One-pot synthesis of 1-substituted 1H-1,2,3,4-tetrazoles from 2aminothiazoles using tributylmethylammonium chloride as a catalyst

2017 ◽  
Vol 23 (5) ◽  
Author(s):  
Kerru Nagaraju ◽  
Gummidi Lalitha ◽  
Parvesh Singh ◽  
Chunduri Venkata Rao
Keyword(s):  
Sodium Azide ◽  
Triethyl Orthoformate ◽  
One Pot ◽  
One Pot Synthesis ◽  
Substituted 1

AbstractReaction between substituted thiazolylamine or oxazolylamine, triethyl orthoformate and sodium azide in the presence of tributylmethylammonium chloride in DMSO furnishes 1-substituted 1

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