scholarly journals Toward Singlet Oxygen Delivery at a Measured Rate: A Self-Reporting Photosensitizer

2014 ◽  
Vol 16 (11) ◽  
pp. 2946-2949 ◽  
Author(s):  
Sundus Erbas-Cakmak ◽  
Engin U. Akkaya
Keyword(s):  
Singlet Oxygen ◽  
Oxygen Delivery ◽  
Measured Rate

Silica nanoreactors from silylated riboflavin for efficient singlet oxygen delivery

2014 ◽  
Vol 2 (27) ◽  
pp. 4221 ◽  
Author(s):  
Natalia C. Angeluzzi ◽  
Marcelo Muñoz ◽  
Daniela T. Marquez ◽  
Mauricio S. Baptista ◽  
Ana Maria Edwards ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Oxygen Delivery

scholarly journals Prostate-specific membrane antigen (PSMA) targeted singlet oxygen delivery via endoperoxide tethered ligands

2022 ◽  
Author(s):  
Lei Wang ◽  
Lei Tang ◽  
Yingjie Liu ◽  
Hao Wu ◽  
Ziang Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Death ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Oxygen Delivery ◽  
Modular Design ◽  
Prostate Specific Membrane Antigen ◽  
Prostate Cancer Cells ◽  
Tethered Ligands ◽  
Specific Membrane

A PSMA targeting ligand is functionalized with endoperoxides which thermally release singlet oxygen. The results show that this modular design results in significantly more cell death in PSMA-expressing prostate cancer cells.

Rose Bengal incorporated in mesostructured silica nanoparticles: structural characterization, theoretical modeling and singlet oxygen delivery

2015 ◽  
Vol 17 (40) ◽  
pp. 26804-26812 ◽  
Author(s):  
B. Martins Estevão ◽  
F. Cucinotta ◽  
N. Hioka ◽  
M. Cossi ◽  
M. Argeri ◽  
...  
Keyword(s):  
Singlet Oxygen ◽  
Silica Nanoparticles ◽  
Structural Characterization ◽  
Rose Bengal ◽  
Oxygen Delivery ◽  
Theoretical Modeling ◽  
Mesostructured Silica

Rose Bengal incorporated into mesostructured silica nanoparticles exhibits efficient singlet oxygen (1O2) generation when illuminated with 540 nm light which is particularly promising for PDT applications.

scholarly journals A Fiberoptic (Photodynamic Therapy Type) Device with a Photosensitizer and Singlet Oxygen Delivery Probe Tip for Ovarian Cancer Cell Killing

2013 ◽  
Vol 89 (4) ◽  
pp. 936-941 ◽  
Author(s):  
Dorota Bartusik ◽  
David Aebisher ◽  
Ashwini Ghogare ◽  
Goutam Ghosh ◽  
Inna Abramova ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Cancer Cell ◽  
Oxygen Delivery ◽  
Ovarian Cancer Cell ◽  
Cell Killing ◽  
Type Device

scholarly journals Singlet Oxygen Delivery Through the Porous Cap of a Hollow-Core Fiber Optic Device

2009 ◽  
Vol 113 (48) ◽  
pp. 15803-15806 ◽  
Author(s):  
Matibur Zamadar ◽  
David Aebisher ◽  
Alexander Greer
Keyword(s):  
Singlet Oxygen ◽  
Oxygen Delivery ◽  
Fiber Optic ◽  
Hollow Core ◽  
Core Fiber

The biochemistry of drugs and doping methods used to enhance aerobic sport performance

2008 ◽  
Vol 44 ◽  
pp. 63-84 ◽  
Author(s):  
Chris E. Cooper
Keyword(s):  
Oxygen Uptake ◽  
Oxygen Content ◽  
Oxygen Delivery ◽  
Sport Performance ◽  
Blood Substitutes ◽  
Altitude Training ◽  
Blood Oxygen ◽  
Oxygen Carriers ◽  
Sports Performance ◽  
Blood Doping

Optimum performance in aerobic sports performance requires an efficient delivery to, and consumption of, oxygen by the exercising muscle. It is probable that maximal oxygen uptake in the athlete is multifactorial, being shared between cardiac output, blood oxygen content, muscle blood flow, oxygen diffusion from the blood to the cell and mitochondrial content. Of these, raising the blood oxygen content by raising the haematocrit is the simplest acute method to increase oxygen delivery and improve sport performance. Legal means of raising haematocrit include altitude training and hypoxic tents. Illegal means include blood doping and the administration of EPO (erythropoietin). The ability to make EPO by genetic means has resulted in an increase in its availability and use, although it is probable that recent testing methods may have had some impact. Less widely used illegal methods include the use of artificial blood oxygen carriers (the so-called ‘blood substitutes’). In principle these molecules could enhance aerobic sports performance; however, they would be readily detectable in urine and blood tests. An alternative to increasing the blood oxygen content is to increase the amount of oxygen that haemoglobin can deliver. It is possible to do this by using compounds that right-shift the haemoglobin dissociation curve (e.g. RSR13). There is a compromise between improving oxygen delivery at the muscle and losing oxygen uptake at the lung and it is unclear whether these reagents would enhance the performance of elite athletes. However, given the proven success of blood doping and EPO, attempts to manipulate these pathways are likely to lead to an ongoing battle between the athlete and the drug testers.

Fluoroquinolone Antimicrobials: Singlet Oxygen, Superoxide and Phototoxicity

1998 ◽  
Vol 67 (4) ◽  
pp. 399 ◽  
Author(s):  
Lydia J. Martínez ◽  
Robert H. Sik ◽  
Colin F. Chignell
Keyword(s):  
Singlet Oxygen
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