Non-Nucleoside Building Blocks for Copper-Assisted and Copper-Free Click Chemistry for the Efficient Synthesis of RNA Conjugates

2010 ◽  
Vol 12 (23) ◽  
pp. 5410-5413 ◽  
Author(s):  
K. N. Jayaprakash ◽  
Chang Geng Peng ◽  
David Butler ◽  
Jos P. Varghese ◽  
Martin A. Maier ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Building Blocks ◽  
Efficient Synthesis

Efficient Synthesis of Glycosylated Asparaginic Acid Building Blocks via Click Chemistry

Synthesis ◽  
2008 ◽  
Vol 2008 (4) ◽  
pp. 519-526 ◽  
Author(s):  
Thomas Ziegler ◽  
Nikolas Pietrzik ◽  
Carsten Schips
Keyword(s):  
Click Chemistry ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Asparaginic Acid

Dithiols as Liquid Crystalline Building Blocks for Smart Polymers via Thiol–yne Click Chemistry

2021 ◽  
Vol 3 (3) ◽  
pp. 1602-1609
Author(s):  
Flavia Lupi ◽  
Daniele Martella ◽  
Sara Nocentini ◽  
Diego Antonioli ◽  
Michele Laus ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Liquid Crystalline ◽  
Building Blocks ◽  
Smart Polymers

Highly efficient synthesis of polymer brushes with PEO and PCL as side chains via click chemistry

Polymer ◽  
2012 ◽  
Vol 53 (10) ◽  
pp. 1992-2000 ◽  
Author(s):  
Peng Zhao ◽  
Yechao Yan ◽  
Xiaoqin Feng ◽  
Lixin Liu ◽  
Chun Wang ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Polymer Brushes ◽  
Side Chains ◽  
Efficient Synthesis ◽  
Highly Efficient

Controlling chirality in the synthesis of 4 + 4 diastereomeric amine macrocycles derived from trans-1,2-diaminocyclopentane and 2,6-diformylpyridine.

2022 ◽  
Author(s):  
Dominka Fedorowicz ◽  
Sylwia Banach ◽  
Patrycja Koza ◽  
Rafał Frydrych ◽  
Katarzyna Ślepokura ◽  
...  
Keyword(s):  
Building Blocks ◽  
Efficient Synthesis

A few suitably long dialdehyde and primary diamine building blocks of a predetermined chirality have been designed and synthesized to enable controlled and efficient synthesis of all 6 possible diastereomers...

Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

2022 ◽  
Author(s):  
Zhi-Gang Yin ◽  
Xiong-Wei Liu ◽  
Hui-Juan Wang ◽  
Min Zhang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Agents ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Design Synthesis ◽  
Pyrone Ring ◽  
Ring Opening Reaction ◽  
First Time

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

Efficient synthesis of polysubstituted 1,5-benzodiazepinone dipeptide mimetics via an Ugi-4CR-Ullmann condensation sequence

Synlett ◽  
2021 ◽  
Author(s):  
Robin Van Den Hauwe ◽  
Mathias Elsocht ◽  
Charlie Hollanders ◽  
Steven Ballet
Keyword(s):  
Building Blocks ◽  
Synthetic Route ◽  
Efficient Synthesis ◽  
Rapid Construction ◽  
Ligand Free

An efficient three step synthesis towards 3-amino-1,4-benzodiazepin-2-one derivatives is presented. The versatile Ugi-4-component reaction (Ugi-4CR) and Boc-deprotection is followed by a ligand-free Ullmann condensation. This protocol allows the rapid construction of a diverse array of substituted 1,5-benzodiazepinones. Since Ugi-based products are typically limited by their ‘inert’ C-terminal amides, the use of a convertible (‘cleavable’) isocyanide was envisaged and resulted in building blocks that can be made SPPS-compatible. To demonstrate the potential of this novel synthetic route, the design and preparation of novel phenylurea-1,5-bezondiazepin-4(5H)-one dipeptide mimetics with potential CCK2-antagonist properties is reported.

Sign in / Sign up

Export Citation Format

Share Document