Systematic Synthesis of Bis-THF Ring Cores in Annonaceous Acetogenins

2003 ◽  
Vol 5 (9) ◽  
pp. 1411-1414 ◽  
Author(s):  
Naoyoshi Maezaki ◽  
Naoto Kojima ◽  
Hiroaki Tominaga ◽  
Minori Yanai ◽  
Tetsuaki Tanaka
Keyword(s):  
Annonaceous Acetogenins ◽  
Systematic Synthesis

Systematic Synthesis of Diastereomeric THF Ring Cores and Total Synthesis of Anti-Tumor Annonaceous Acetogenins

Synlett ◽  
2006 ◽  
Vol 2006 (07) ◽  
pp. 0993-1003 ◽  
Author(s):  
Tetsuaki Tanaka ◽  
Naoyoshi Maezaki ◽  
Naoto Kojima
Keyword(s):  
Total Synthesis ◽  
Annonaceous Acetogenins ◽  
Systematic Synthesis

Annonaceous acetogenins within extracts: dereplication by HPLC-ESI-LTQ-Orbitrap® using post-column lithium infusion

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
J Le Ven ◽  
I Schmitz-Afonso ◽  
G Lewin ◽  
O Laprévote ◽  
A Brunelle ◽  
...  
Keyword(s):  
Annonaceous Acetogenins

scholarly journals The Oxford Catalogue of Opioids: a systematic synthesis of opioid drug names and their pharmacology

2021 ◽  
Author(s):  
Georgia C. Richards ◽  
Konrad Sitkowski ◽  
Carl Heneghan ◽  
Jeffrey K. Aronson
Keyword(s):  
Drug Names ◽  
Systematic Synthesis

The P‐graph approach for systematic synthesis of wastewater treatment networks

AIChE Journal ◽  
2021 ◽  
Author(s):  
Kirti M. Yenkie ◽  
Jean Pimentel ◽  
Ákos Orosz ◽  
Heriberto Cabezas ◽  
Ferenc Friedler
Keyword(s):  
Wastewater Treatment ◽  
Systematic Synthesis

Antitumor activity of annonaceous acetogenins in HepS and S180 xenografts bearing mice

2012 ◽  
Vol 22 (8) ◽  
pp. 2717-2719 ◽  
Author(s):  
Yong Chen ◽  
Jian-wei Chen ◽  
Sha-sha Xu ◽  
Yu Wang ◽  
Xiang Li ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Annonaceous Acetogenins

Practical Isolation of Bullatacin from Annona muricata Leaves Extract Using an Open Column Chromatography Technique

2013 ◽  
Vol 789 ◽  
pp. 545-550 ◽  
Author(s):  
Kamarza Mulia ◽  
Silvester W. Winarcahyo ◽  
Elsa Krisanti ◽  
Dewi Kurniasuci
Keyword(s):  
Column Chromatography ◽  
Separation Procedure ◽  
Annona Muricata ◽  
Methanol Fraction ◽  
Annonaceous Acetogenins ◽  
Anti Cancer ◽  
Standard Compound ◽  
Lactone Group ◽  
Dark Green ◽  
Ethanol Fraction

Annonaceous acetogenins are bioactive compounds present in the leaves of Annona muricata (soursop) with significant anti-cancer activities. In this study, acetogenin-rich ethanol fraction extracted from soursop leaves was further separated and isolated using a simple open column chromatography technique with silica gel as the stationary phase. The separation procedure consists of three steps, each step employing sequential elution with organic solvents having different polarity as the eluent. Eluted fractions rich in acetogenin compounds were identified using the Kedde reagent which formed a distinctive dark green complex with the unsaturated γ-lactone group present in all of the annonaceous acetogenin compounds. HPLC analysis showed that the initial methanol fraction, as well as isolates from the second and the third isolation steps, contain bullatacin, squamocin, squamostatin-A, and squamostatin-D. Bullatacin produced from this study can be used further as a standard compound for quantitative analysis of other acetogenin compounds contained in soursop leaves extract.

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