A New Strategy toward the Total Synthesis of Stachyflin, A Potent Anti-Influenza A Virus Agent:  Concise Route to the Tetracyclic Core Structure

2002 ◽  
Vol 4 (25) ◽  
pp. 4483-4486 ◽  
Author(s):  
Mari Nakatani ◽  
Masahiko Nakamura ◽  
Akiyuki Suzuki ◽  
Munenori Inoue ◽  
Tadashi Katoh
Keyword(s):  
Total Synthesis ◽  
Influenza A Virus ◽  
Influenza A ◽  
Core Structure ◽  
New Strategy ◽  
Tetracyclic Core

A New Strategy Toward the Total Synthesis of Stachyflin (I), a Potent Antiinfluenza A Virus Agent: Concise Route to the Tetracyclic Core Structure (II).

ChemInform ◽  
2003 ◽  
Vol 34 (17) ◽  
Author(s):  
Mari Nakatani ◽  
Masahiko Nakamura ◽  
Akiyuki Suzuki ◽  
Munenori Inoue ◽  
Tadashi Katoh
Keyword(s):  
Total Synthesis ◽  
Core Structure ◽  
New Strategy ◽  
Tetracyclic Core

scholarly journals The Functional Role of Loops and Flanking Sequences of G-Quadruplex Aptamer to the Hemagglutinin of Influenza a Virus

2021 ◽  
Vol 22 (5) ◽  
pp. 2409
Author(s):  
Anastasia A. Bizyaeva ◽  
Dmitry A. Bunin ◽  
Valeria L. Moiseenko ◽  
Alexandra S. Gambaryan ◽  
Sonja Balk ◽  
...  
Keyword(s):  
Influenza A Virus ◽  
Influenza A ◽  
Core Structure ◽  
Dna Aptamer ◽  
Tertiary Structures ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Flanking Sequences ◽  
Related Proteins

Nucleic acid aptamers are generally accepted as promising elements for the specific and high-affinity binding of various biomolecules. It has been shown for a number of aptamers that the complexes with several related proteins may possess a similar affinity. An outstanding example is the G-quadruplex DNA aptamer RHA0385, which binds to the hemagglutinins of various influenza A virus strains. These hemagglutinins have homologous tertiary structures but moderate-to-low amino acid sequence identities. Here, the experiment was inverted, targeting the same protein using a set of related, parallel G-quadruplexes. The 5′- and 3′-flanking sequences of RHA0385 were truncated to yield parallel G-quadruplex with three propeller loops that were 7, 1, and 1 nucleotides in length. Next, a set of minimal, parallel G-quadruplexes with three single-nucleotide loops was tested. These G-quadruplexes were characterized both structurally and functionally. All parallel G-quadruplexes had affinities for both recombinant hemagglutinin and influenza virions. In summary, the parallel G-quadruplex represents a minimal core structure with functional activity that binds influenza A hemagglutinin. The flanking sequences and loops represent additional features that can be used to modulate the affinity. Thus, the RHA0385–hemagglutinin complex serves as an excellent example of the hypothesis of a core structure that is decorated with additional recognizing elements capable of improving the binding properties of the aptamer.

Total synthesis study of rauvomines A and B: construction of the pentacyclic core structure

2020 ◽  
Vol 7 (13) ◽  
pp. 1685-1689
Author(s):  
Binglu Wu ◽  
Zhi-Jiang Jiang ◽  
Jianbo Tang ◽  
Zhanghua Gao ◽  
Hongze Liang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Aldol Reaction ◽  
Core Structure ◽  
Mukaiyama Aldol Reaction ◽  
New Strategy ◽  
Mukaiyama Aldol ◽  
Pentacyclic Core

The fifth ring of rauvomines can be annulated via a Mukaiyama-Aldol reaction as a new strategy for sarpagine scaffold construction.

Total synthesis of (+)-stachyflin: a potential anti-influenza A virus agent

2010 ◽  
Vol 46 (23) ◽  
pp. 4055 ◽  
Author(s):  
Kazuhiro Watanabe ◽  
Junji Sakurai ◽  
Hideki Abe ◽  
Tadashi Katoh
Keyword(s):  
Total Synthesis ◽  
Influenza A Virus ◽  
Influenza A

Enantioselective Total Synthesis of (+)-Stachyflin: A Potential Anti-Influenza A Virus Agent Isolated from a Microorganism

2011 ◽  
Vol 2011 (16) ◽  
pp. 2948-2957 ◽  
Author(s):  
Junji Sakurai ◽  
Takuya Kikuchi ◽  
Ohgi Takahashi ◽  
Kazuhiro Watanabe ◽  
Tadashi Katoh
Keyword(s):  
Total Synthesis ◽  
Influenza A Virus ◽  
Influenza A ◽  
Enantioselective Total Synthesis
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