Organometallic Photonucleases:  Synthesis and DNA-Cleavage Studies of Cyclopentadienyl Metal-Substituted Dendrimers Designed To Increase Double-Strand Scission

2000 ◽  
Vol 2 (18) ◽  
pp. 2745-2748 ◽  
Author(s):  
Allison L. Hurley ◽  
Debra L. Mohler
Keyword(s):  
Dna Cleavage ◽  
Strand Scission ◽  
Cyclopentadienyl Metal

DNA Cleavage by the Photolysis of Cyclopentadienyl Metal Complexes:  Mechanistic Studies and Sequence Selectivity of Strand Scission by CpW(CO)3CH3

2005 ◽  
Vol 70 (23) ◽  
pp. 9093-9102 ◽  
Author(s):  
Debra L. Mohler ◽  
Jennifer R. Downs ◽  
Allison L. Hurley-Predecki ◽  
Jennifer R. Sallman ◽  
Peter M. Gannett ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Mechanistic Studies ◽  
Strand Scission ◽  
Sequence Selectivity ◽  
Cyclopentadienyl Metal

scholarly journals The DNA cleavage mechanism of iron-bleomycin. Kinetic resolution of strand scission from base propenal release.

1986 ◽  
Vol 261 (34) ◽  
pp. 15955-15959
Author(s):  
R M Burger ◽  
S J Projan ◽  
S B Horwitz ◽  
J Peisach
Keyword(s):  
Dna Cleavage ◽  
Kinetic Resolution ◽  
Strand Scission

Studies related to antitumor antibiotics. Part VII. Synthesis of streptonigrin analogues and their single strand scission of DNA

1976 ◽  
Vol 54 (16) ◽  
pp. 2563-2572 ◽  
Author(s):  
J. William Lown ◽  
Soo-Khoon Sim
Keyword(s):  
Antitumor Activity ◽  
Dna Cleavage ◽  
Single Strand ◽  
Antitumor Antibiotic ◽  
Antitumor Antibiotics ◽  
Substitution Pattern ◽  
Circular Dna ◽  
Strand Scission ◽  
Independent Synthesis ◽  
Selective Catalysis

The syntheses of a group of 2-(o-nitrophenyl)- and 2-(o-aminophenyl)-5,8-quinolinediones which are structurally related to the antitumor antibiotic streptonigrin are described. Ambiguities in the position of required nucleophilic displacements are resolved by independent synthesis. The rates of single strand cleavage of PM2 ccc-DNA (covalently-closed circular-DNA) induced by these compounds are compared, which correlates with antitumor activity. The 2-(o-nitrophenyl) derivatives give consistently more rapid DNA cleavage than the 2-(o-aminophenyl) compounds. The autoxidations of the dihydroxyquinolines are subject to selective catalysis by Cu2+ on. 2-(o-Aminophenyl)-7-amino-6-methoxy-5,6-quinolinedione which has a substitution pattern most closely resembling streptonigrin also closely parallels the rate of scission of DNA of the latter in the presence of NADPH.

Photoinduced DNA Cleavage by Cyclopentadienyl Metal Complexes Conjugated to DNA Recognition Elements

2001 ◽  
Vol 3 (17) ◽  
pp. 2761-2764 ◽  
Author(s):  
Allison L. Hurley ◽  
Mitchell P. Maddox ◽  
Tricia L. Scott ◽  
Mark R. Flood ◽  
Debra L. Mohler
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Dna Recognition ◽  
Recognition Elements ◽  
Cyclopentadienyl Metal
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