Photoinduced DNA Cleavage by Cyclopentadienyl Metal Complexes Conjugated to DNA Recognition Elements

2001 ◽  
Vol 3 (17) ◽  
pp. 2761-2764 ◽  
Author(s):  
Allison L. Hurley ◽  
Mitchell P. Maddox ◽  
Tricia L. Scott ◽  
Mark R. Flood ◽  
Debra L. Mohler
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Dna Recognition ◽  
Recognition Elements ◽  
Cyclopentadienyl Metal

DNA Cleavage by the Photolysis of Cyclopentadienyl Metal Complexes:  Mechanistic Studies and Sequence Selectivity of Strand Scission by CpW(CO)3CH3

2005 ◽  
Vol 70 (23) ◽  
pp. 9093-9102 ◽  
Author(s):  
Debra L. Mohler ◽  
Jennifer R. Downs ◽  
Allison L. Hurley-Predecki ◽  
Jennifer R. Sallman ◽  
Peter M. Gannett ◽  
...  
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Mechanistic Studies ◽  
Strand Scission ◽  
Sequence Selectivity ◽  
Cyclopentadienyl Metal

DNA cleavage mechanism by metal complexes of Cu(II), Zn(II) and VO(IV) with a schiff-base ligand

Biochimie ◽  
2021 ◽  
Vol 186 ◽  
pp. 43-50
Author(s):  
María R. Rodríguez ◽  
Martín J. Lavecchia ◽  
Beatriz S. Parajón-Costa ◽  
Ana C. González-Baró ◽  
María R. González-Baró ◽  
...  
Keyword(s):  
Schiff Base ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage

Synthesis, characterization, antimicrobial, and DNA cleavage studies of metal complexes of coumarin Schiff bases

2010 ◽  
Vol 20 (4) ◽  
pp. 493-502 ◽  
Author(s):  
Mohammedshafi A. Phaniband ◽  
Shreedhar D. Dhumwad ◽  
Shashikanth R. Pattan
Keyword(s):  
Metal Complexes ◽  
Schiff Bases ◽  
Dna Cleavage

Synthesis, structural characterisation, bio-potential efficiency and DNA cleavage applications of nicotinamide metal complexes

2013 ◽  
Vol 1040 ◽  
pp. 192-205 ◽  
Author(s):  
C. Surendra Dilip ◽  
V. Siva Kumar ◽  
S. John Venison ◽  
I. Vetha potheher ◽  
D. Rajalaxmi (a) Subahashini
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Structural Characterisation ◽  
Potential Efficiency

scholarly journals Cu(II) and Ni(II) Complexes with New Tridentate NNS Thiosemicarbazones: Synthesis, Characterisation, DNA Interaction, and Antibacterial Activity

2019 ◽  
Vol 2019 ◽  
pp. 1-14 ◽  
Author(s):  
Dorian Polo-Cerón
Keyword(s):  
Metal Complexes ◽  
Dna Cleavage ◽  
Thermal Analyses ◽  
Dna Interaction ◽  
Antimicrobial Activities ◽  
Tridentate Ligand ◽  
Bacterial Strains ◽  
Azomethine Group ◽  
Broth Microdilution Method

This paper reports the synthesis and detailed characterisation of copper(II) and nickel(II) complexes with tridentate thiosemicarbazone ligands H2L1 and H2L2 derived from 2-acetylpyrazine. The ligands and their metal complexes were characterised by different physicochemical techniques, including elemental and thermogravimetric analysis; UV-Vis, IR, 1H-NMR, and 13C-NMR spectroscopy; molar conductance measurements; and mass spectrometry. The crystal structure of the H2L1 ligand was determined by single crystal X-ray diffraction studies. The spectral data showed that the thiosemicarbazone behaves as an NNS tridentate ligand through the nitrogen atoms of the azomethine group and pyrazine ring and the sulphur atom of the thioamide group. Elemental and thermal analyses indicated that the obtained metal complexes had a 1 : 1 stoichiometry (metal-ligand). The interactions between these complexes and calf thymus DNA (CT-DNA) were studied by electronic absorption and viscosity measurements. The activities of these compounds against oxidative DNA cleavage were examined by agarose gel electrophoresis. Cu(II) and Ni(II) complexes can wind DNA strands through groove interactions and promote strand breakage of the plasmid pmCherry under oxidative stress conditions. Moreover, all the complexes could interact more strongly with DNA than could with the free ligands. Finally, the antibacterial activities of the ligands and their complexes were determined by in vitro tests against Gram-positive bacterial strains (S. aureus ATCC 25923, L. monocytogenes ATCC 19115, and B. cereus ATCC 10876) and Gram-negative bacterial strains (E. coli ATCC 25922, S. typhimurium ATCC 14028, and K. pneumoniae ATCC BAA-2146) using the broth microdilution method. The metal complexes showed greater antimicrobial activities than the precursor ligands against some of the microorganisms.

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