Isolation of Potential Cancer Chemopreventive Agents from Eriodictyon californicum

1992 ◽  
Vol 55 (3) ◽  
pp. 357-363 ◽  
Author(s):  
Yong-Long Liu ◽  
David K. Ho ◽  
John M. Cassady ◽  
Vanessa M. Cook ◽  
William M. Baird
Keyword(s):  
Chemopreventive Agents ◽  
Eriodictyon Californicum ◽  
Potential Cancer

scholarly journals Biotransformation of the Phenolic Constituents from Licorice and Cytotoxicity Evaluation of Their Metabolites

2021 ◽  
Vol 22 (18) ◽  
pp. 10109
Author(s):  
Yina Xiao ◽  
Fubo Han ◽  
Ik-Soo Lee
Keyword(s):  
Cell Lines ◽  
Human Cancer ◽  
Chemical Diversity ◽  
Cytotoxic Activities ◽  
Chemopreventive Agents ◽  
Human Cancer Cell Lines ◽  
Biotransformation Process ◽  
Phenolic Constituents ◽  
Potential Cancer ◽  
Mcf 7

Biotransformation of four bioactive phenolic constituents from licorice, namely licoisoflavanone (1), glycyrrhisoflavone (2), echinatin (3), and isobavachalcone (4), was performed by the selected fungal strain Aspergillus niger KCCM 60332, leading to the isolation of seventeen metabolites (5–21). Structures of the isolated compounds were determined on the basis of extensive spectroscopic methods, twelve of which (5–7, 10–17 and 19) have been previously undescribed. A series of reactions including hydroxylation, hydrogenation, epoxidation, hydrolysis, reduction, cyclization, and alkylation was observed in the biotransformation process. All compounds were tested for their cytotoxic activities against three different human cancer cell lines including A375P, MCF-7, and HT-29. Compounds 1 and 12 exhibited most considerable cytotoxic activities against all the cell lines investigated, while compounds 2 and 4 were moderately cytotoxic. These findings will contribute to expanding the chemical diversity of phenolic compounds, and compounds 1 and 12 may serve as leads for the development of potential cancer chemopreventive agents.

Use of azoxymethane-induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents

1994 ◽  
Vol 15 (5) ◽  
pp. 1049-1054 ◽  
Author(s):  
Michael A. Pereira ◽  
Leta H. Barnes ◽  
Vicki L. Rassman ◽  
Gary V. Kelloff ◽  
Vernon E. Steele
Keyword(s):  
Rat Colon ◽  
Chemopreventive Agents ◽  
Aberrant Crypts ◽  
Potential Cancer

scholarly journals Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents

2014 ◽  
Vol 55 (47) ◽  
pp. 6500-6503 ◽  
Author(s):  
Rui-Juan Li ◽  
Yu Zhao ◽  
Harukuni Tokuda ◽  
Xiao-Ming Yang ◽  
Yue-Hu Wang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Chemopreventive Agents ◽  
Potential Cancer

Mechanism-based in vitro screening of potential cancer chemopreventive agents

2003 ◽  
Vol 523-524 ◽  
pp. 163-172 ◽  
Author(s):  
Clarissa Gerhäuser ◽  
Karin Klimo ◽  
Elke Heiss ◽  
Isabell Neumann ◽  
Amira Gamal-Eldeen ◽  
...  
Keyword(s):  
In Vitro Screening ◽  
Chemopreventive Agents ◽  
Potential Cancer

Potential cancer chemopreventive agents fromArbutus unedo

2006 ◽  
Vol 20 (4) ◽  
pp. 327-334 ◽  
Author(s):  
Esperanza J. Carcache-Blanco ◽  
Muriel Cuendet ◽  
Eun Jung Park‡ ◽  
Bao-Ning Su§ ◽  
J. Fausto Rivero-Cruz ◽  
...  
Keyword(s):  
Chemopreventive Agents ◽  
Potential Cancer

Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents

2004 ◽  
Vol 325 (1) ◽  
pp. 287-295 ◽  
Author(s):  
Elisabeth Bertl ◽  
Hans Becker ◽  
Theophil Eicher ◽  
Christian Herhaus ◽  
Govind Kapadia ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Chemopreventive Agents ◽  
Cell Functions ◽  
Potential Cancer
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