Natural Products as a Source of Potential Cancer Chemotherapeutic and Chemopreventive Agents

1990 ◽  
Vol 53 (1) ◽  
pp. 23-41 ◽  
Author(s):  
John M. Cassady ◽  
William M. Baird ◽  
Ching-Jer Chang
Keyword(s):  
Natural Products ◽  
Chemopreventive Agents ◽  
Potential Cancer

scholarly journals Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma

2015 ◽  
Vol 2015 ◽  
pp. 1-26 ◽  
Author(s):  
Chen-Yi Liao ◽  
Ching-Chang Lee ◽  
Chi-chang Tsai ◽  
Chao-Wen Hsueh ◽  
Chih-Chiang Wang ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Natural Products ◽  
Multidrug Resistance ◽  
Intracellular Signaling ◽  
Poor Prognosis ◽  
Biological Effects ◽  
Herbal Medicines ◽  
Chemopreventive Agents ◽  
Intracellular Signaling Pathways ◽  
Anticancer Effects

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signaling pathways and serve as antioxidants. In this review, we will discuss seven common flavonoids that exert different biological effects against HCC via different pathways.

scholarly journals POTENTIAL NATURAL PRODUCTS WITH ANTICANCER PROPERTIES AND THEIR APPLICATIONS

2019 ◽  
pp. 27-33 ◽  
Author(s):  
BALABHASKAR R ◽  
RAJENDRA KUMAR A ◽  
SELVARAJAN S ◽  
FARIDHA A ◽  
GAYATHRI GUNALAN
Keyword(s):  
Natural Products ◽  
Anticancer Agents ◽  
World Population ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Chemopreventive Agents ◽  
Anticancer Properties ◽  
Drug Molecules ◽  
Animal Resources ◽  
Drug Leads

Natural products continue to be a source for the discovery of drugs and drug leads even from ancient period. 80% of drug molecules have been obtained from either natural products or derivatives of the natural product. It has been found that the concept of a single drug for treating single disease may become outdated in the near future and the need of polyherbal formulations, as an alternate remedy is under investigation. Medicinal and aromatic plants contain biologically important phytochemicals, which have known curative properties. They are found as secondary metabolites in plants. Plants also contain certain other compounds that moderate the effects of the active ingredients. Medicinal and aromatic plants have their own contribution toward the treatment of both noncommunicable and communicable diseases. A survey done by the WHO indicates that a majority of the world population tends to use plants for treating diseases. Cancer, the second largest cause of death after cardiovascular disease accounts for about 3500 million people globally. Due to the serious side effects of synthetic chemopreventive agents, research is going onto investigate the nature derived chemopreventive agents. In addition to the plant-derived compounds, marine, and animal resources also play an important role as clinically beneficial anticancer agents with minimal or no toxicity. The best examples for plant-derived compounds include vincristine, vinblastine, irinotecan, etoposide, and paclitaxel; they have a different mode of action against cancer such as interaction with microtubules, inhibition of topoisomerases I or II, alkylation of DNA, and interference with tumor signal transduction. The natural products from marine sources such as bryostatin, squalamine exhibit a significant antimitotic, and anti-angiogenic activities. The benefits of various anticancer drugs derived from natural products are the fact that it can have its effect on cancer cells alone without harming healthy cells, which is unlikely to be the case with other conventional chemotherapeutics. In this review, various natural products and their anticancer properties have been discussed briefly.

scholarly journals Natural products as potential cancer therapy enhancers: A preclinical update

2014 ◽  
Vol 2 ◽  
pp. 205031211454692 ◽  
Author(s):  
Abed Agbarya ◽  
Nili Ruimi ◽  
Ron Epelbaum ◽  
Eran Ben-Arye ◽  
Jamal Mahajna
Keyword(s):  
Natural Products ◽  
Cancer Therapy ◽  
Potential Cancer

scholarly journals Natural Products as Chemopreventive Agents by Potential Inhibition of the Kinase Domain in ErbB Receptors

Molecules ◽  
2017 ◽  
Vol 22 (2) ◽  
pp. 308 ◽  
Author(s):  
Maria Olivero-Acosta ◽  
Wilson Maldonado-Rojas ◽  
Jesus Olivero-Verbel
Keyword(s):  
Natural Products ◽  
Kinase Domain ◽  
Erbb Receptors ◽  
Chemopreventive Agents

Bioactive Natural Products From the Genus Kalanchoe as Cancer Chemopreventive Agents: A Review

2019 ◽  
pp. 49-84 ◽  
Author(s):  
P. García-Pérez ◽  
M.E. Barreal ◽  
L. Rojo-De Dios ◽  
J.F. Cameselle-Teijeiro ◽  
P.P. Gallego
Keyword(s):  
Natural Products ◽  
Chemopreventive Agents ◽  
Bioactive Natural Products
Sign in / Sign up

Export Citation Format

Share Document