Erratum. New Macrocyclic Trichothecenes from Baccharis megapotamica

1987 ◽  
Vol 50 (6) ◽  
pp. 1186-1186 ◽  
Author(s):  
B Jarvis ◽  
S Cäezoglu ◽  
H Ammon ◽  
C Breedlove ◽  
R Miller ◽  
...  
Keyword(s):  
Macrocyclic Trichothecenes ◽  
Baccharis Megapotamica

New Macrocyclic Trichothecenes from Baccharis megapotamica

1987 ◽  
Vol 50 (5) ◽  
pp. 815-828 ◽  
Author(s):  
Bruce B. Jarvis ◽  
S. Nilgun Cämezoglu ◽  
Herman L. Ammon ◽  
Christine K. Breedlove ◽  
Richard W. Miller ◽  
...  
Keyword(s):  
Macrocyclic Trichothecenes ◽  
Baccharis Megapotamica

ChemInform Abstract: Isolation of Macrocyclic Trichothecenes from a Large-Scale Extract of Baccharis megapotamica.

ChemInform ◽  
1987 ◽  
Vol 18 (28) ◽  
Author(s):  
B. B. JARVIS ◽  
S. N. COEMEZOGLU ◽  
M. M. RAO ◽  
N. B. PENA ◽  
F. E. BOETTNER ◽  
...  
Keyword(s):  
Large Scale ◽  
Macrocyclic Trichothecenes ◽  
Baccharis Megapotamica

scholarly journals Experimental poisoning by Baccharis megapotamica var. weirii in buffalo

2012 ◽  
Vol 32 (5) ◽  
pp. 383-390 ◽  
Author(s):  
José C. Oliveira-Filho ◽  
Priscila M.S. Carmo ◽  
Anita Iversen ◽  
Kristian F. Nielsen ◽  
Claudio S.L. Barros
Keyword(s):  
Mass Spectrometry ◽  
High Performance ◽  
Clinical Signs ◽  
Watery Diarrhea ◽  
Murrah Buffalo ◽  
Macrocyclic Trichothecenes ◽  
Flight Mass Spectrometry ◽  
Aerial Parts ◽  
Baccharis Megapotamica ◽  
Fibrin Thrombi

Five male 6-8 month-old Murrah buffalo calves were orally dosed with the fresh aerial parts of Baccharis megapotamica var. weirii at doses of 1, 3, 4, 5 and 10g/kg body weight (bw) (~1-10mg macrocyclic trichothecenes/kg/bw). The B. megapotamica used for the experiment was harvested on a farm where a recent spontaneous outbreak of poisoning caused by such plant had occurred. Clinical signs appeared 4-20 hours and 4 buffaloes died 18-49 hours after the ingestion of the plant. Clinical signs were apathy, anorexia, and watery diarrhea, fever, colic, drooling, muscle tremors, restlessness, laborious breathing and ruminal atony, and dehydration. The most consistent gross findings were restricted to the gastrointestinal (GI) tract consisted of varying degrees of edema and reddening of the mucosa of the forestomach. Histopathological findings consisted of varying degrees of necrosis of the epithelial lining of the forestomach and of lymphocytes within lymphoid organs and aggregates. Fibrin thrombi were consistently found in sub-mucosal vessels of the forestomach and in the lumen of hepatic sinusoids. It is suggested that dehydration, septicemia and disseminated intravascular coagulation participate in the pathogenesis of the intoxication and play a role as a cause of death. A subsample of B. megapotamica var. weirii was frozen-dried and ground and analyzed using UHPLC (Ultra High Performance Liquid Chromatography) with high resolution Time of Flight mass spectrometry and tandem mass spectrometry, it was shown that the plant material contained at least 51 different macrocyclic trichothecenes at a total level of 1.1-1.2mg/g. About 15-20% of the total trichothecenes contents was found to be monosaccharide conjugates, with two thirds of these being glucose conjugates and one third constituted by six aldopentose conjugates (probably xylose), which has never been reported in the literature.

Novel Macrocyclic Trichothecenes from Myrothecium Roridum

2010 ◽  
Vol 95 (9-10) ◽  
pp. 681-697 ◽  
Author(s):  
Bruce B. Jarvis ◽  
F. Taha Çömezoglu ◽  
Yin-Won Lee ◽  
Judith L. Flippen-Anderson ◽  
Richard D. Gilardi ◽  
...  
Keyword(s):  
Macrocyclic Trichothecenes ◽  
Myrothecium Roridum

scholarly journals Intoxicação natural por Baccharis megapotamica var.weirii em caprinos

2015 ◽  
Vol 35 (4) ◽  
pp. 360-364 ◽  
Author(s):  
Welden Panziera ◽  
Maiara A. Gonçalves ◽  
Marina P. Lorenzett ◽  
Pedro Damboriarena ◽  
Fernando F. Argenta ◽  
...  
Keyword(s):  
Rio Grande ◽  
Rio Grande Do Sul ◽  
Baccharis Megapotamica ◽  
Intestino Delgado

Intoxicações por plantas do gênero Baccharis representam uma importante causa de morte em animais de produção. Baccharis coridifoliae Baccharis megapotamica são as espécies mais comuns e importantes. Nesse trabalho, são descritos os aspectos epidemiológicos, clínicos e anatomopatológicos de um surto de intoxicação natural por Baccharis megapotamicavar. weirii em caprinos. Onze caprinos jovens, de um total de 152, foram afetados por uma doença aguda fatal. Os casos ocorreram em uma pequena propriedade rural no município de Viamão, Rio Grande do Sul, Brasil. Grande quantidade de exemplares de Baccharis megapotamicavar. weirii em estágio de floração, foram encontrados onde os caprinos estavam. As plantas cresceram em áreas úmidas e alagadas. Os caprinos afetados tinham entre seis meses a um ano de idade e todos apresentaram sinais clínicos caracterizados por apatia, anorexia, prostração, diarreia, desidratação, desconforto abdominal, timpanismo, decúbito e morte. O curso clínico variou aproximadamente de 12 a 24 horas. Dos onze caprinos acometidos, três foram necropsiados. As alterações presentes em todas as necropsias incluíam desidratação, conteúdo líquido no rúmen, avermelhamento, erosões e úlceras da mucosa dos pré-estômagos, e avermelhamento na mucosa do abomaso e intestino. Um dos caprinos apresentou marcada hemorragia dos linfonodos mesentéricos. As lesões histológicas de todos os caprinos necropsiados incluíam hiperemia, hemorragia, alterações degenerativas, necróticas e ulcerativas variadas no revestimento epitelial do rúmen, retículo e omaso, e na mucosa do abomaso e de alguns segmentos do intestino delgado. Necrose do tecido linfoide foi observada em linfonodos mesentéricos e em agregados linfoides no intestino e folículos do baço.

scholarly journals Recent Advances on Macrocyclic Trichothecenes, Their Bioactivities and Biosynthetic Pathway

Toxins ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 417
Author(s):  
Muzi Zhu ◽  
Youfei Cen ◽  
Wei Ye ◽  
Saini Li ◽  
Weimin Zhang
Keyword(s):  
Phylogenetic Trees ◽  
Biosynthetic Pathway ◽  
Antitumor Agents ◽  
Food Contamination ◽  
Hydroxyl Group ◽  
Side Chain ◽  
Important Group ◽  
Search Results ◽  
Macrocyclic Trichothecenes ◽  
Biologic Activity

Macrocyclic trichothecenes are an important group of trichothecenes bearing a large ring. Despite the fact that many of trichothecenes are of concern in agriculture, food contamination, health care and building protection, the macrocyclic ones are becoming the research hotspot because of their diversity in structure and biologic activity. Several researchers have declared that macrocyclic trichothecenes have great potential to be developed as antitumor agents, due to the plenty of their compounds and bioactivities. In this review we summarize the newly discovered macrocyclic trichothecenes and their bioactivities over the last decade, as well as identifications of genes tri17 and tri18 involved in the trichothecene biosynthesis and putative biosynthetic pathway. According to the search results in database and phylogenetic trees generated in the review, the species of the genera Podostroma and Monosporascus would probably be great sources for producing macrocyclic trichothecenes. Moreover, we propose that the macrocyclic trichothecene roridin E could be formed via acylation or esterification of the long side chain linked with C-4 to the hydroxyl group at C-15, and vice versa. More assays and evidences are needed to support this hypothesis, which would promote the verification of the proposed pathway.

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