Evaluation of the Antiviral Activity Against Junin Virus of Macrocyclic Trichothecenes Produced by the Hypocrealean Epibiont of Baccharis coridifolia

Planta Medica ◽  
2002 ◽  
Vol 68 (3) ◽  
pp. 209-212 ◽  
Author(s):  
C. C. García ◽  
M. L. Rosso ◽  
M. D. Bertoni ◽  
M. S. Maier ◽  
E. B. Damonte
Keyword(s):  
Antiviral Activity ◽  
Junin Virus ◽  
Macrocyclic Trichothecenes ◽  
Baccharis Coridifolia ◽  
Junín Virus

Antiviral activity of A771726, the active metabolite of leflunomide, against Junín virus

2018 ◽  
Vol 90 (5) ◽  
pp. 819-827 ◽  
Author(s):  
Claudia S. Sepúlveda ◽  
Cybele C. García ◽  
Elsa B. Damonte
Keyword(s):  
Antiviral Activity ◽  
Active Metabolite ◽  
Junin Virus ◽  
Junín Virus

Polysulfonates Derived from Metal Thiolate Complexes as Inhibitors of HIV-1 and Various other Enveloped Viruses In Vitro

2002 ◽  
Vol 13 (3) ◽  
pp. 185-195 ◽  
Author(s):  
Donald E Bergstrom ◽  
Xiaoping Lin ◽  
Troy D Wood ◽  
Myriam Witvrouw ◽  
Satoru Ikeda ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Palladium Complex ◽  
Platinum Complex ◽  
Cadmium Complex ◽  
Junin Virus ◽  
Tacaribe Virus ◽  
Junín Virus ◽  
Hiv 1 ◽  
Hsv 1

Sodium 2-mercaptoethanesulfonate reacts with the metal ions Pd(II), Pt(II), Ag(I), Cd(II) and Zn(II) to yield complexes containing multiple anionic sulfonate sites. On the basis of spectroscopic and other analytical data the complexes were assigned the tentative molecular formulas: Pd6(SCH2CH2SO3Na)12, Ptn(SCH2CH2SO3Na)2n+2, Agn(SCH2CH2SO3Na)n, Na2Zn4(SCH2CH2SO3Na)10, and Na2Cd4(SCH2CH2SO3Na)10. The complexes displayed a variety of differences in activity towards DNA and RNA viruses. The platinum complex showed no measurable cytotoxicity and exhibited a spectrum of antiviral activity resembling that of dextran sulfate. It was active against HIV-1 and HIV-2, herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), thymidine kinase-deficient HSV-1, human cytomegalovirus, vesicular stomatitis virus (VSV), influenza A virus, respiratory syncytial virus (RSV), Sindbis virus, Junin virus and Tacaribe virus. The palladium complex also showed no measurable cytotoxicity, but was completely inactive against most viruses, with one notable exception: both HIV-1 and HIV-2 were substantially inhibited by the palladium complex. The silver complex showed significantly less antiviral activity and greater cytotoxicity than the platinum complex but did show some selectivity against RSV. The zinc complex showed only modest activity against VSV, RSV, Junin virus, and Tacaribe virus, and like the silver compound was more cytotoxic than either the platinum or palladium complex. The cadmium complex was toxic to all of the cell lines used for in vitro evaluation of antiviral activity. Based on these results, the platinum and palladium compounds appear to be promising candidates for further studies, that is, as vaginal microbicides in the prevention of genital HIV and/or HSV transmission.

ChemInform Abstract: Imidazo[2,1-b]thiazole Carbohydrate Derivatives: Synthesis and Antiviral Activity Against Junin Virus, Agent of Argentine Hemorrhagic Fever.

ChemInform ◽  
2011 ◽  
Vol 42 (22) ◽  
pp. no-no
Author(s):  
Jose Sebastian Barradas ◽  
Maria Ines Errea ◽  
Norma B. D'Accorso ◽  
Claudia Soledad Sepulveda ◽  
Elsa Beatriz Damonte
Keyword(s):  
Antiviral Activity ◽  
Hemorrhagic Fever ◽  
Junin Virus ◽  
Argentine Hemorrhagic Fever ◽  
Junín Virus

scholarly journals A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that Junín Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR)

2017 ◽  
Vol 91 (15) ◽  
Author(s):  
Benjamin R. King ◽  
Dylan Hershkowitz ◽  
Philip L. Eisenhauer ◽  
Marion E. Weir ◽  
Christopher M. Ziegler ◽  
...  
Keyword(s):  
Life Cycle ◽  
Protein Kinase ◽  
Antiviral Activity ◽  
Viral Life Cycle ◽  
Host Protein ◽  
Data Set ◽  
Double Stranded Rna ◽  
Junin Virus ◽  
Protein Interactome ◽  
Junín Virus

ABSTRACT Arenaviruses are enveloped negative-strand RNA viruses that cause significant human disease. These viruses encode only four proteins to accomplish the viral life cycle, so each arenavirus protein likely plays unappreciated accessory roles during infection. Here we used immunoprecipitation and mass spectrometry to identify human proteins that interact with the nucleoproteins (NPs) of the Old World arenavirus lymphocytic choriomeningitis virus (LCMV) and the New World arenavirus Junín virus (JUNV) strain Candid #1. Bioinformatic analysis of the identified protein partners of NP revealed that host translation appears to be a key biological process engaged during infection. In particular, NP associates with the double-stranded RNA (dsRNA)-activated protein kinase (PKR), a well-characterized antiviral protein that inhibits cap-dependent protein translation initiation via phosphorylation of eIF2α. JUNV infection leads to increased expression of PKR as well as its redistribution to viral replication and transcription factories. Further, phosphorylation of PKR, which is a prerequisite for its ability to phosphorylate eIF2α, is readily induced by JUNV. However, JUNV prevents this pool of activated PKR from phosphorylating eIF2α, even following exposure to the synthetic dsRNA poly(I·C), a potent PKR agonist. This blockade of PKR function is highly specific, as LCMV is unable to similarly inhibit eIF2α phosphorylation. JUNV's ability to antagonize the antiviral activity of PKR appears to be complete, as silencing of PKR expression has no impact on viral propagation. In summary, we provide a detailed map of the host machinery engaged by arenavirus NPs and identify an antiviral pathway that is subverted by JUNV. IMPORTANCE Arenaviruses are important human pathogens for which FDA-approved vaccines do not exist and effective antiviral therapeutics are needed. Design of antiviral treatment options and elucidation of the mechanistic basis of disease pathogenesis will depend on an increased basic understanding of these viruses and, in particular, their interactions with the host cell machinery. Identifying host proteins critical for the viral life cycle and/or pathogenesis represents a useful strategy to uncover new drug targets. This study reveals, for the first time, the extensive human protein interactome of arenavirus nucleoproteins and uncovers a potent antiviral host protein that is neutralized during Junín virus infection. In so doing, it shows further insight into the interplay between the virus and the host innate immune response and provides an important data set for the field.

Imidazo[2,1-b]thiazole carbohydrate derivatives: Synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever

2011 ◽  
Vol 46 (1) ◽  
pp. 259-264 ◽  
Author(s):  
José Sebastián Barradas ◽  
María Inés Errea ◽  
Norma B. D'Accorso ◽  
Claudia Soledad Sepúlveda ◽  
Elsa Beatriz Damonte
Keyword(s):  
Antiviral Activity ◽  
Hemorrhagic Fever ◽  
Junin Virus ◽  
Argentine Hemorrhagic Fever ◽  
Junín Virus

Junin virus activity in two rural populations of the Argentine hemorrhagic fever (AHF) endemic area

1983 ◽  
Vol 12 (4) ◽  
pp. 273-280 ◽  
Author(s):  
Mercedes C. Weissenbacher ◽  
Marta S. Sabattini ◽  
María M. Avila ◽  
Patricia M. Sangiorgio ◽  
María R. F. De Sensi ◽  
...  
Keyword(s):  
Endemic Area ◽  
Hemorrhagic Fever ◽  
Rural Populations ◽  
Junin Virus ◽  
Argentine Hemorrhagic Fever ◽  
Virus Activity ◽  
Junín Virus

A Rapid Method for Detecting Junin Virus Viremia in the Guinea Pig

Intervirology ◽  
1977 ◽  
Vol 8 (6) ◽  
pp. 360-363 ◽  
Author(s):  
Adriana Rabinovich ◽  
Patricio M. Cossio ◽  
Guadalupe Carballal ◽  
Roberto M. Arana
Keyword(s):  
Guinea Pig ◽  
Rapid Method ◽  
Junin Virus ◽  
Junín Virus

scholarly journals Development of Peptide-Conjugated Morpholino Oligomers as Pan-Arenavirus Inhibitors

2011 ◽  
Vol 55 (10) ◽  
pp. 4631-4638 ◽  
Author(s):  
Benjamin W. Neuman ◽  
Lydia H. Bederka ◽  
David A. Stein ◽  
Joey P. C. Ting ◽  
Hong M. Moulton ◽  
...  
Keyword(s):  
Cell Cultures ◽  
Treatment Options ◽  
Hemorrhagic Fever ◽  
Virus Genome ◽  
Lymphocytic Choriomeningitis ◽  
Content Type ◽  
Junin Virus ◽  
Pichinde Virus ◽  
Junín Virus

ABSTRACTMembers of theArenaviridaefamily are a threat to public health and can cause meningitis and hemorrhagic fever, and yet treatment options remain limited by a lack of effective antivirals. In this study, we found that peptide-conjugated phosphorodiamidate morpholino oligomers (PPMO) complementary to viral genomic RNA were effective in reducing arenavirus replication in cell cultures andin vivo. PPMO complementary to the Junín virus genome were designed to interfere with viral RNA synthesis or translation or both. However, only PPMO designed to potentially interfere with translation were effective in reducing virus replication. PPMO complementary to sequences that are highly conserved across the arenaviruses and located at the 5′ termini of both genomic segments were effective against Junín virus, Tacaribe virus, Pichinde virus, and lymphocytic choriomeningitis virus (LCMV)-infected cell cultures and suppressed viral titers in the livers of LCMV-infected mice. These results suggest that arenavirus 5′ genomic termini represent promising targets for pan-arenavirus antiviral therapeutic development.

Effect of Ribavirin on Junin Virus Infection in Guinea Pigs

2012 ◽  
Vol 59 (4) ◽  
pp. 278-285 ◽  
Author(s):  
M. Salazar ◽  
N. E. Yun ◽  
A. L. Poussard ◽  
J. N. Smith ◽  
J. K. Smith ◽  
...  
Keyword(s):  
Virus Infection ◽  
Guinea Pigs ◽  
Junin Virus ◽  
Junín Virus
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