Chemical Studies on Mexican Plants Used in Traditional Medicine, III: New 4-Phenylcoumarins from Exostema caribaeum

1987 ◽  
Vol 50 (5) ◽  
pp. 866-871 ◽  
Author(s):  
Rachel Mata ◽  
Fernando Calzada ◽  
Ma Rosario Garcia ◽  
Ma Teresa Reguero
1988 ◽  
Vol 36 (7) ◽  
pp. 2689-2690 ◽  
Author(s):  
KENJI MIZUTANI ◽  
MASAMICHI YUDA ◽  
OSAMU TANAKA ◽  
YUH-ICHIROU SARUWATARI ◽  
TOHRU FUWA ◽  
...  

1987 ◽  
Vol 50 (2) ◽  
pp. 315-316 ◽  
Author(s):  
María Teresa Reguero ◽  
Rachel Mata ◽  
Robert Bye ◽  
Edelmira Linares ◽  
Guillermo Delgado

1991 ◽  
Vol 54 (3) ◽  
pp. 913-917 ◽  
Author(s):  
Rachel Mata ◽  
José Luis Contreras ◽  
Daniel Crisanto ◽  
Rogelio Pereda-Miranda ◽  
Perla Castañeda ◽  
...  

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Kelly Cristina Oliveira de Albuquerque ◽  
Andreza do Socorro Silva da Veiga ◽  
João Victor da Silva e Silva ◽  
Heliton Patrick Cordovil Brigido ◽  
Erica Patrícia dos Reis Ferreira ◽  
...  

The present study describes the use of the traditional speciesCopaiferafor treating wounds, such as ulcers scarring and antileishmanial wounds. It also relates phytochemical studies, evaluation of the leishmanicidal activity, and toxicity. The species ofCopaiferawith a higher incidence in the Amazon region areCopaifera officinalis,Copaifera reticulata,Copaifera multijugaHayne. The copaiba oil is used in the Amazon’s traditional medicine, especially as anti-inflammatory ingredient, in ulcers healing, and in scarring and for leishmaniasis. Chemical studies have shown that these oils contain diterpenes and sesquiterpenes. The copaiba oil and terpenes isolated have antiparasitic activity, more promising in the amastigote form ofL. amazonensis. This activity is probably related to changes in the cell membrane and mitochondria. The oil showed low cytotoxicity and genotoxicity. Furthermore, it may interfere with immune response to infection and also has a healing effect. In summary, the copaiba oil is promising as leishmanicidal agent.


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