scholarly journals Polyethylene-Glycol-Modified Single-Walled Carbon Nanotubes for Intra-Articular Delivery to Chondrocytes

ACS Nano ◽  
2014 ◽  
Vol 8 (12) ◽  
pp. 12280-12291 ◽  
Author(s):  
Cristiano Sacchetti ◽  
Ru Liu-Bryan ◽  
Andrea Magrini ◽  
Nicola Rosato ◽  
Nunzio Bottini ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Polyethylene Glycol ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

scholarly journals Chemically Functionalized Water-Soluble Single-Walled Carbon Nanotubes Obstruct Vesicular/Plasmalemmal Recycling in Astrocytes Down-Stream of Calcium Ions

Cells ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 1597
Author(s):  
Manoj K. Gottipati ◽  
Elena Bekyarova ◽  
Robert C. Haddon ◽  
Vladimir Parpura
Keyword(s):  
Carbon Nanotubes ◽  
Plasma Membrane ◽  
Polyethylene Glycol ◽  
Adenosine Triphosphate ◽  
Calcium Ions ◽  
Glutamate Release ◽  
Single Walled Carbon Nanotubes ◽  
Water Soluble ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

We used single-walled carbon nanotubes chemically functionalized with polyethylene glycol (SWCNT-PEG) to assess the effects of this nanomaterial on astrocytic endocytosis and exocytosis. We observed that the SWCNT-PEG do not affect the adenosine triphosphate (ATP)-evoked Ca2+ elevations in astrocytes but significantly reduce the Ca2+-dependent glutamate release. There was a significant decrease in the endocytic load of the recycling dye during constitutive and ATP-evoked recycling. Furthermore, SWCNT-PEG hampered ATP-evoked exocytotic release of the loaded recycling dye. Thus, by functionally obstructing evoked vesicular recycling, SWCNT-PEG reduced glutamate release from astrocytes via regulated exocytosis. These effects implicate SWCNT-PEG as a modulator of Ca2+-dependent exocytosis in astrocytes downstream of Ca2+, likely at the level of vesicle fusion with/pinching off the plasma membrane.

Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery

2018 ◽  
Vol 7 (6) ◽  
pp. 1700916 ◽  
Author(s):  
Kunal Bhattacharya ◽  
Cristiano Sacchetti ◽  
Pedro M. Costa ◽  
Jens Sommertune ◽  
Birgit D. Brandner ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Nanotubes ◽  
Polyethylene Glycol ◽  
Single Walled Carbon Nanotubes ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

scholarly journals Aqueous dispersion of single walled carbon nanotubes stabilized by PEG modified diperylene bisimide and their application as an antibacterial agent

RSC Advances ◽  
2017 ◽  
Vol 7 (42) ◽  
pp. 26125-26129 ◽  
Author(s):  
Yan Sun ◽  
Zhibo Li
Keyword(s):  
Carbon Nanotubes ◽  
Polyethylene Glycol ◽  
Antibacterial Agent ◽  
Aqueous Dispersion ◽  
Single Walled Carbon Nanotubes ◽  
Antibacterial Activities ◽  
Single Walled Carbon ◽  
Walled Carbon Nanotubes

Polyethylene glycol modified diperylene bisimide was synthesized and applied to disperse single-walled carbon nanotubes in water. Moreover, the well-dispersed SWCNTs show excellent antibacterial activities.

scholarly journals Effects of Chemically-Functionalized Single-Walled Carbon Nanotubes on the Morphology and Vitality of D54MG Human Glioblastoma Cells

Neuroglia ◽  
2018 ◽  
Vol 1 (2) ◽  
pp. 327-338 ◽  
Author(s):  
Seantel Hopkins ◽  
Manoj Gottipati ◽  
Vedrana Montana ◽  
Elena Bekyarova ◽  
Robert Haddon ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Cell Death ◽  
Polyethylene Glycol ◽  
Death Rate ◽  
Single Walled Carbon Nanotubes ◽  
Glioblastoma Cells ◽  
Human Glioblastoma ◽  
Single Walled Carbon ◽  
Human Glioblastoma Cells ◽  
Walled Carbon Nanotubes

The unique properties of single-walled carbon nanotubes (SWCNTs) have made them interesting candidates for applications in biomedicine. There are diverse chemical groups that can be attached to SWCNTs in order for these tiny tubes to gain various functionalities, for example, water solubility. Due to the availability of these “functionalization” approaches, SWCNTs are seen as agents for a potential anti-cancer therapy. In this context, we tested different chemically-functionalized forms of SWCNTs to determine which modifications make them better combatants against glioblastoma (astrocytoma grade IV), the deadliest brain cancer. We investigated the effects that two types of water soluble SWCNTs, functionalized with polyethylene glycol (SWCNT-PEG) or tetrahydrofurfuryl-terminated polyethylene glycol (SWCNT-PEG-THFF), have on the morphology and vitality, that is, cell adhesion, proliferation and death rate, of the D54MG human glioblastoma cells in culture. We found that SWCNT-PEG-THFF solute, when added to culture media, makes D54MG cells less round (measured as a significant decrease, by ~23%, in the form factor). This morphological change was induced by the PEG-THFF functional group, but not the SWCNT backbone itself. We also found that SWCNT-PEG-THFF solute reduces the proliferation rate of D54MG cells while increasing the rate of cell death. The functional groups PEG and PEG-THFF, on the other hand, reduce the cell death rate of D54MG human glioma cells. These data indicate that the process of functionalization of SWCNTs for potential use as glioma therapeutics may affect their biological effects.

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